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PubMed code 16824757

Compile data set for download or QSAR
Found 67 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190994
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylph...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1C
Show InChI InChI=1S/C27H38ClN3O/c1-18(2)14-25(29)24-15-19(3)6-9-26(24)30-10-12-31(13-11-30)27(32)21(5)16-22-7-8-23(28)17-20(22)4/h6-9,15,17-18,21,25H,10-14,16,29H2,1-5H3/t21-,25+/m1/s1
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5.90n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190978
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Show SMILES COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O2/c1-17(2)13-23(32)22-15-20(27(29,30)31)6-8-24(22)33-9-11-34(12-10-33)26(35)18(3)14-19-5-7-21(28)16-25(19)36-4/h5-8,15-18,23H,9-14,32H2,1-4H3/t18-,23+/m1/s1
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6.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191013
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylph...)
Show SMILES COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(CC1)c1ccc(C)cc1[C@@H](N)CC(C)C
Show InChI InChI=1S/C27H38ClN3O2/c1-18(2)14-24(29)23-15-19(3)6-9-25(23)30-10-12-31(13-11-30)27(32)20(4)16-21-7-8-22(28)17-26(21)33-5/h6-9,15,17-18,20,24H,10-14,16,29H2,1-5H3/t20-,24+/m1/s1
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8.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190987
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylph...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C26H35Cl2N3O/c1-17(2)13-24(29)22-14-18(3)5-8-25(22)30-9-11-31(12-10-30)26(32)19(4)15-20-6-7-21(27)16-23(20)28/h5-8,14,16-17,19,24H,9-13,15,29H2,1-4H3/t19-,24+/m1/s1
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8.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191008
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-chlorophenyl...)
Show SMILES COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(CC1)c1ccc(Cl)cc1[C@@H](N)CC(C)C
Show InChI InChI=1S/C26H35Cl2N3O2/c1-17(2)13-23(29)22-15-20(27)7-8-24(22)30-9-11-31(12-10-30)26(32)18(3)14-19-5-6-21(28)16-25(19)33-4/h5-8,15-18,23H,9-14,29H2,1-4H3/t18?,23-/m0/s1
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9.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190972
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)phenyl)pipe...)
Show SMILES CC(C)C[C@H](N)c1ccccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1C
Show InChI InChI=1S/C26H36ClN3O/c1-18(2)15-24(28)23-7-5-6-8-25(23)29-11-13-30(14-12-29)26(31)20(4)16-21-9-10-22(27)17-19(21)3/h5-10,17-18,20,24H,11-16,28H2,1-4H3/t20-,24+/m1/s1
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12n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190976
PNG
((1S)-[2-{4-[2-methyl-3-(2-methoxy-4-chlorophenyl)p...)
Show SMILES COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O2/c1-17(2)13-23(32)22-15-20(27(29,30)31)6-8-24(22)33-9-11-34(12-10-33)26(35)18(3)14-19-5-7-21(28)16-25(19)36-4/h5-8,15-18,23H,9-14,32H2,1-4H3/t18?,23-/m0/s1
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14n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191030
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)phenyl)pipe...)
Show SMILES CC(C)C[C@H](N)c1ccccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C25H33Cl2N3O/c1-17(2)14-23(28)21-6-4-5-7-24(21)29-10-12-30(13-11-29)25(31)18(3)15-19-8-9-20(26)16-22(19)27/h4-9,16-18,23H,10-15,28H2,1-3H3/t18-,23+/m1/s1
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16n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191028
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylph...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1F
Show InChI InChI=1S/C26H35ClFN3O/c1-17(2)13-24(29)22-14-18(3)5-8-25(22)30-9-11-31(12-10-30)26(32)19(4)15-20-6-7-21(27)16-23(20)28/h5-8,14,16-17,19,24H,9-13,15,29H2,1-4H3/t19-,24+/m1/s1
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20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190975
PNG
((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C26H36ClN3O/c1-18(2)15-24(28)23-16-19(3)5-10-25(23)29-11-13-30(14-12-29)26(31)20(4)17-21-6-8-22(27)9-7-21/h5-10,16,18,20,24H,11-15,17,28H2,1-4H3/t20-,24+/m1/s1
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25n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191011
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C26H32Cl2F3N3O/c1-16(2)12-23(32)21-14-19(26(29,30)31)5-7-24(21)33-8-10-34(11-9-33)25(35)17(3)13-18-4-6-20(27)15-22(18)28/h4-7,14-17,23H,8-13,32H2,1-3H3/t17-,23+/m1/s1
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26n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191017
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C26H33ClF3N3O/c1-17(2)14-23(31)22-16-20(26(28,29)30)6-9-24(22)32-10-12-33(13-11-32)25(34)18(3)15-19-4-7-21(27)8-5-19/h4-9,16-18,23H,10-15,31H2,1-3H3/t18-,23+/m1/s1
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31n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191018
PNG
((S)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Show SMILES COc1cc(Cl)ccc1C[C@H](C)C(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O2/c1-17(2)13-23(32)22-15-20(27(29,30)31)6-8-24(22)33-9-11-34(12-10-33)26(35)18(3)14-19-5-7-21(28)16-25(19)36-4/h5-8,15-18,23H,9-14,32H2,1-4H3/t18-,23-/m0/s1
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31n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190992
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)cc1O)C(F)(F)F
Show InChI InChI=1S/C26H33ClF3N3O2/c1-16(2)12-22(31)21-14-19(26(28,29)30)5-7-23(21)32-8-10-33(11-9-32)25(35)17(3)13-18-4-6-20(27)15-24(18)34/h4-7,14-17,22,34H,8-13,31H2,1-3H3/t17?,22-/m0/s1
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36n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190980
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)cc1C)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O/c1-17(2)13-24(32)23-16-21(27(29,30)31)6-8-25(23)33-9-11-34(12-10-33)26(35)19(4)14-20-5-7-22(28)15-18(20)3/h5-8,15-17,19,24H,9-14,32H2,1-4H3/t19?,24-/m0/s1
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38n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190985
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C26H33ClF3N3O/c1-17(2)14-23(31)22-16-20(26(28,29)30)6-9-24(22)32-10-12-33(13-11-32)25(34)18(3)15-19-4-7-21(27)8-5-19/h4-9,16-18,23H,10-15,31H2,1-3H3/t18?,23-/m0/s1
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47n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191004
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)cc1F)C(F)(F)F
Show InChI InChI=1S/C26H32ClF4N3O/c1-16(2)12-23(32)21-14-19(26(29,30)31)5-7-24(21)33-8-10-34(11-9-33)25(35)17(3)13-18-4-6-20(27)15-22(18)28/h4-7,14-17,23H,8-13,32H2,1-3H3/t17?,23-/m0/s1
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60n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190998
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)phenyl)pipe...)
Show SMILES CC(C)C[C@H](N)c1ccccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1F
Show InChI InChI=1S/C25H33ClFN3O/c1-17(2)14-23(28)21-6-4-5-7-24(21)29-10-12-30(13-11-29)25(31)18(3)15-19-8-9-20(26)16-22(19)27/h4-9,16-18,23H,10-15,28H2,1-3H3/t18-,23+/m1/s1
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67n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190979
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-chlorophenyl...)
Show SMILES CC(C)C[C@H](N)c1cc(Cl)ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C25H33Cl2N3O/c1-17(2)14-23(28)22-16-21(27)8-9-24(22)29-10-12-30(13-11-29)25(31)18(3)15-19-4-6-20(26)7-5-19/h4-9,16-18,23H,10-15,28H2,1-3H3/t18?,23-/m0/s1
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67n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190991
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)c(C)c1)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O/c1-17(2)13-24(32)22-16-21(27(29,30)31)6-8-25(22)33-9-11-34(12-10-33)26(35)19(4)15-20-5-7-23(28)18(3)14-20/h5-8,14,16-17,19,24H,9-13,15,32H2,1-4H3/t19?,24-/m0/s1
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71n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191027
PNG
((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)phenyl)pipe...)
Show SMILES CC(C)C[C@H](N)c1ccccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN3O/c1-18(2)16-23(27)22-6-4-5-7-24(22)28-12-14-29(15-13-28)25(30)19(3)17-20-8-10-21(26)11-9-20/h4-11,18-19,23H,12-17,27H2,1-3H3/t19-,23+/m1/s1
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80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Homo sapiens (Human))
BDBM50190976
PNG
((1S)-[2-{4-[2-methyl-3-(2-methoxy-4-chlorophenyl)p...)
Show SMILES COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O2/c1-17(2)13-23(32)22-15-20(27(29,30)31)6-8-24(22)33-9-11-34(12-10-33)26(35)18(3)14-19-5-7-21(28)16-25(19)36-4/h5-8,15-18,23H,9-14,32H2,1-4H3/t18?,23-/m0/s1
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86n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190993
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O/c1-18(2)14-25(32)24-17-23(28(29,30)31)8-9-26(24)33-10-12-34(13-11-33)27(35)21(5)16-22-7-6-19(3)15-20(22)4/h6-9,15,17-18,21,25H,10-14,16,32H2,1-5H3/t21?,25-/m0/s1
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92n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190973
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C26H32Cl2F3N3O/c1-16(2)12-23(32)20-15-19(26(29,30)31)5-7-24(20)33-8-10-34(11-9-33)25(35)17(3)13-18-4-6-21(27)22(28)14-18/h4-7,14-17,23H,8-13,32H2,1-3H3/t17?,23-/m0/s1
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120n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190973
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C26H32Cl2F3N3O/c1-16(2)12-23(32)20-15-19(26(29,30)31)5-7-24(20)33-8-10-34(11-9-33)25(35)17(3)13-18-4-6-21(27)22(28)14-18/h4-7,14-17,23H,8-13,32H2,1-3H3/t17?,23-/m0/s1
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120n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191019
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1ccc(CC(C)C(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)cc1
Show InChI InChI=1S/C27H36F3N3O2/c1-18(2)15-24(31)23-17-21(27(28,29)30)7-10-25(23)32-11-13-33(14-12-32)26(34)19(3)16-20-5-8-22(35-4)9-6-20/h5-10,17-19,24H,11-16,31H2,1-4H3/t19?,24-/m0/s1
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120n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191016
PNG
((S)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](C)Cc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C26H32Cl2F3N3O/c1-16(2)12-23(32)21-14-19(26(29,30)31)5-7-24(21)33-8-10-34(11-9-33)25(35)17(3)13-18-4-6-20(27)15-22(18)28/h4-7,14-17,23H,8-13,32H2,1-3H3/t17-,23-/m0/s1
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140n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191014
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-chlorophenyl...)
Show SMILES COc1ccc(CC(C)C(=O)N2CCN(CC2)c2ccc(Cl)cc2[C@@H](N)CC(C)C)cc1
Show InChI InChI=1S/C26H36ClN3O2/c1-18(2)15-24(28)23-17-21(27)7-10-25(23)29-11-13-30(14-12-29)26(31)19(3)16-20-5-8-22(32-4)9-6-20/h5-10,17-19,24H,11-16,28H2,1-4H3/t19?,24-/m0/s1
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160n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191020
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1ccc(CC(C)C(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)cc1F
Show InChI InChI=1S/C27H35F4N3O2/c1-17(2)13-23(32)21-16-20(27(29,30)31)6-7-24(21)33-9-11-34(12-10-33)26(35)18(3)14-19-5-8-25(36-4)22(28)15-19/h5-8,15-18,23H,9-14,32H2,1-4H3/t18?,23-/m0/s1
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200n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190995
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1cc(CC(C)C(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)ccc1Cl
Show InChI InChI=1S/C27H35ClF3N3O2/c1-17(2)13-23(32)21-16-20(27(29,30)31)6-8-24(21)33-9-11-34(12-10-33)26(35)18(3)14-19-5-7-22(28)25(15-19)36-4/h5-8,15-18,23H,9-14,32H2,1-4H3/t18?,23-/m0/s1
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230n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190984
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(C)c(C)c1)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O/c1-18(2)14-25(32)24-17-23(28(29,30)31)8-9-26(24)33-10-12-34(13-11-33)27(35)21(5)16-22-7-6-19(3)20(4)15-22/h6-9,15,17-18,21,25H,10-14,16,32H2,1-5H3/t21?,25-/m0/s1
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240n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50190976
PNG
((1S)-[2-{4-[2-methyl-3-(2-methoxy-4-chlorophenyl)p...)
Show SMILES COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O2/c1-17(2)13-23(32)22-15-20(27(29,30)31)6-8-24(22)33-9-11-34(12-10-33)26(35)18(3)14-19-5-7-21(28)16-25(19)36-4/h5-8,15-18,23H,9-14,32H2,1-4H3/t18?,23-/m0/s1
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320n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190988
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-fluorophenyl...)
Show SMILES CC(C)C[C@H](N)c1cc(F)ccc1N1CCN(CC1)C(=O)C(C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C25H33ClFN3O/c1-17(2)14-23(28)22-16-21(27)8-9-24(22)29-10-12-30(13-11-29)25(31)18(3)15-19-4-6-20(26)7-5-19/h4-9,16-18,23H,10-15,28H2,1-3H3/t18?,23-/m0/s1
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390n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191009
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCC(=O)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C26H31ClF3N3O2/c1-17(2)15-22(31)21-16-19(26(28,29)30)5-8-23(21)32-11-13-33(14-12-32)25(35)10-9-24(34)18-3-6-20(27)7-4-18/h3-8,16-17,22H,9-15,31H2,1-2H3/t22-/m0/s1
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820n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190982
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)C(C)Cc1cccc(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C26H33ClF3N3O/c1-17(2)13-23(31)22-16-20(26(28,29)30)7-8-24(22)32-9-11-33(12-10-32)25(34)18(3)14-19-5-4-6-21(27)15-19/h4-8,15-18,23H,9-14,31H2,1-3H3/t18?,23-/m0/s1
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920n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 5 (MC5R)


(Homo sapiens (Human))
BDBM50190975
PNG
((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C26H36ClN3O/c1-18(2)15-24(28)23-16-19(3)5-10-25(23)29-11-13-30(14-12-29)26(31)20(4)17-21-6-8-22(27)9-7-21/h5-10,16,18,20,24H,11-15,17,28H2,1-4H3/t20-,24+/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC5R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191024
PNG
(4-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CC(C)C(=O)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C27H33ClF3N3O2/c1-17(2)14-23(32)22-16-20(27(29,30)31)6-9-24(22)33-10-12-34(13-11-33)25(35)15-18(3)26(36)19-4-7-21(28)8-5-19/h4-9,16-18,23H,10-15,32H2,1-3H3/t18?,23-/m0/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 3 (MC3R)


(Homo sapiens (Human))
BDBM50190975
PNG
((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C26H36ClN3O/c1-18(2)15-24(28)23-16-19(3)5-10-25(23)29-11-13-30(14-12-29)26(31)20(4)17-21-6-8-22(27)9-7-21/h5-10,16,18,20,24H,11-15,17,28H2,1-4H3/t20-,24+/m1/s1
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1.30E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC3R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191005
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CSc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3OS/c1-15(2)11-20(30)18-12-16(24(27,28)29)3-5-21(18)31-7-9-32(10-8-31)23(33)14-34-22-6-4-17(25)13-19(22)26/h3-6,12-13,15,20H,7-11,14,30H2,1-2H3/t20-/m0/s1
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1.50E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191010
PNG
((R)-1-(4-(2-((R)-1-amino-3-methylbutyl)phenyl)pipe...)
Show SMILES CC(C)C[C@@H](N)c1ccccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1C
Show InChI InChI=1S/C26H36ClN3O/c1-18(2)15-24(28)23-7-5-6-8-25(23)29-11-13-30(14-12-29)26(31)20(4)16-21-9-10-22(27)17-19(21)3/h5-10,17-18,20,24H,11-16,28H2,1-4H3/t20-,24-/m1/s1
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1.70E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191015
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc2ccccc2c1)C(F)(F)F
Show InChI InChI=1S/C28H32F3N3O2/c1-19(2)15-25(32)24-17-22(28(29,30)31)8-10-26(24)33-11-13-34(14-12-33)27(35)18-36-23-9-7-20-5-3-4-6-21(20)16-23/h3-10,16-17,19,25H,11-15,18,32H2,1-2H3/t25-/m0/s1
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2.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191012
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)Cn1cnc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C25H30F3N5O/c1-17(2)13-20(29)19-14-18(25(26,27)28)7-8-22(19)31-9-11-32(12-10-31)24(34)15-33-16-30-21-5-3-4-6-23(21)33/h3-8,14,16-17,20H,9-13,15,29H2,1-2H3/t20-/m0/s1
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2.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191006
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CCOc1cccc(CC(C)C(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)c1
Show InChI InChI=1S/C28H38F3N3O2/c1-5-36-23-8-6-7-21(17-23)16-20(4)27(35)34-13-11-33(12-14-34)26-10-9-22(28(29,30)31)18-24(26)25(32)15-19(2)3/h6-10,17-20,25H,5,11-16,32H2,1-4H3/t20?,25-/m0/s1
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2.20E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191003
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(Cl)c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O2/c1-15(2)11-21(30)18-12-16(24(27,28)29)3-6-22(18)31-7-9-32(10-8-31)23(33)14-34-17-4-5-19(25)20(26)13-17/h3-6,12-13,15,21H,7-11,14,30H2,1-2H3/t21-/m0/s1
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2.50E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191022
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1cccc(Cl)c1Cl)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O2/c1-15(2)12-19(30)17-13-16(24(27,28)29)6-7-20(17)31-8-10-32(11-9-31)22(33)14-34-21-5-3-4-18(25)23(21)26/h3-7,13,15,19H,8-12,14,30H2,1-2H3/t19-/m0/s1
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2.50E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191002
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1cccc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C28H32F3N3O2/c1-19(2)16-24(32)23-17-21(28(29,30)31)10-11-25(23)33-12-14-34(15-13-33)27(35)18-36-26-9-5-7-20-6-3-4-8-22(20)26/h3-11,17,19,24H,12-16,18,32H2,1-2H3/t24-/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190989
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1cccc(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C24H29ClF3N3O2/c1-16(2)12-21(29)20-13-17(24(26,27)28)6-7-22(20)30-8-10-31(11-9-30)23(32)15-33-19-5-3-4-18(25)14-19/h3-7,13-14,16,21H,8-12,15,29H2,1-2H3/t21-/m0/s1
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2.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191021
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)Cc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O/c1-15(2)11-21(30)19-13-17(24(27,28)29)4-6-22(19)31-7-9-32(10-8-31)23(33)12-16-3-5-18(25)14-20(16)26/h3-6,13-15,21H,7-12,30H2,1-2H3/t21-/m0/s1
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2.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191000
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C24H29ClF3N3O2/c1-16(2)13-21(29)20-14-17(24(26,27)28)3-8-22(20)30-9-11-31(12-10-30)23(32)15-33-19-6-4-18(25)5-7-19/h3-8,14,16,21H,9-13,15,29H2,1-2H3/t21-/m0/s1
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2.90E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190990
PNG
(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1cccc(CC(C)C(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)c1
Show InChI InChI=1S/C27H36F3N3O2/c1-18(2)14-24(31)23-17-21(27(28,29)30)8-9-25(23)32-10-12-33(13-11-32)26(34)19(3)15-20-6-5-7-22(16-20)35-4/h5-9,16-19,24H,10-15,31H2,1-4H3/t19?,24-/m0/s1
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3.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50190975
PNG
((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C26H36ClN3O/c1-18(2)15-24(28)23-16-19(3)5-10-25(23)29-11-13-30(14-12-29)26(31)20(4)17-21-6-8-22(27)9-7-21/h5-10,16,18,20,24H,11-15,17,28H2,1-4H3/t20-,24+/m1/s1
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3.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC1R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191007
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(cc1)[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C24H29F3N4O4/c1-16(2)13-21(28)20-14-17(24(25,26)27)3-8-22(20)29-9-11-30(12-10-29)23(32)15-35-19-6-4-18(5-7-19)31(33)34/h3-8,14,16,21H,9-13,15,28H2,1-2H3/t21-/m0/s1
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3.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190996
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CNc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H31F3N4O/c1-17(2)14-21(28)20-15-18(24(25,26)27)8-9-22(20)30-10-12-31(13-11-30)23(32)16-29-19-6-4-3-5-7-19/h3-9,15,17,21,29H,10-14,16,28H2,1-2H3/t21-/m0/s1
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3.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190974
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES COc1ccc(OCC(=O)N2CCN(CC2)c2ccc(cc2[C@@H](N)CC(C)C)C(F)(F)F)cc1
Show InChI InChI=1S/C25H32F3N3O3/c1-17(2)14-22(29)21-15-18(25(26,27)28)4-9-23(21)30-10-12-31(13-11-30)24(32)16-34-20-7-5-19(33-3)6-8-20/h4-9,15,17,22H,10-14,16,29H2,1-3H3/t22-/m0/s1
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3.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190983
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C26H34F3N3O2/c1-17(2)13-22(30)21-15-20(26(27,28)29)6-7-23(21)31-9-11-32(12-10-31)25(33)16-34-24-8-5-18(3)14-19(24)4/h5-8,14-15,17,22H,9-13,16,30H2,1-4H3/t22-/m0/s1
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4.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191001
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCCC1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C26H40F3N3O/c1-19(2)17-23(30)22-18-21(26(27,28)29)11-12-24(22)31-13-15-32(16-14-31)25(33)10-6-9-20-7-4-3-5-8-20/h11-12,18-20,23H,3-10,13-17,30H2,1-2H3/t23-/m0/s1
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4.10E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190981
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(Cl)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O2/c1-15(2)11-20(30)18-12-16(24(27,28)29)3-5-21(18)31-7-9-32(10-8-31)23(33)14-34-22-6-4-17(25)13-19(22)26/h3-6,12-13,15,20H,7-11,14,30H2,1-2H3/t20-/m0/s1
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4.20E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190999
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1S/C25H32F3N3O2/c1-17(2)14-22(29)21-15-19(25(26,27)28)6-9-23(21)30-10-12-31(13-11-30)24(32)16-33-20-7-4-18(3)5-8-20/h4-9,15,17,22H,10-14,16,29H2,1-3H3/t22-/m0/s1
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4.40E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191023
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccccc1Cl)C(F)(F)F
Show InChI InChI=1S/C24H29ClF3N3O2/c1-16(2)13-20(29)18-14-17(24(26,27)28)7-8-21(18)30-9-11-31(12-10-30)23(32)15-33-22-6-4-3-5-19(22)25/h3-8,14,16,20H,9-13,15,29H2,1-2H3/t20-/m0/s1
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4.50E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191029
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccc(O)cc1)C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O3/c1-16(2)13-21(28)20-14-17(24(25,26)27)3-8-22(20)29-9-11-30(12-10-29)23(32)15-33-19-6-4-18(31)5-7-19/h3-8,14,16,21,31H,9-13,15,28H2,1-2H3/t21-/m0/s1
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4.60E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190986
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCNC1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C25H39F3N4O/c1-18(2)16-22(29)21-17-19(25(26,27)28)8-9-23(21)31-12-14-32(15-13-31)24(33)10-11-30-20-6-4-3-5-7-20/h8-9,17-18,20,22,30H,3-7,10-16,29H2,1-2H3/t22-/m0/s1
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4.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190997
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCC1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C25H38F3N3O/c1-18(2)16-22(29)21-17-20(25(26,27)28)9-10-23(21)30-12-14-31(15-13-30)24(32)11-8-19-6-4-3-5-7-19/h9-10,17-19,22H,3-8,11-16,29H2,1-2H3/t22-/m0/s1
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5.70E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190977
PNG
((S)-4-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCC(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H29F3N4O2/c1-13(2)11-16(24)15-12-14(20(21,22)23)3-4-17(15)26-7-9-27(10-8-26)19(29)6-5-18(25)28/h3-4,12-13,16H,5-11,24H2,1-2H3,(H2,25,28)/t16-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191025
PNG
((S)-1-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)COc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O2/c1-17(2)14-21(28)20-15-18(24(25,26)27)8-9-22(20)29-10-12-30(13-11-29)23(31)16-32-19-6-4-3-5-7-19/h3-9,15,17,21H,10-14,16,28H2,1-2H3/t21-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50191026
PNG
((S)-4-(4-(2-(1-amino-3-methylbutyl)-4-(trifluorome...)
Show SMILES CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)CCC(=O)N(C)C)C(F)(F)F
Show InChI InChI=1S/C22H33F3N4O2/c1-15(2)13-18(26)17-14-16(22(23,24)25)5-6-19(17)28-9-11-29(12-10-28)21(31)8-7-20(30)27(3)4/h5-6,14-15,18H,7-13,26H2,1-4H3/t18-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190975
PNG
((1S)-(2-{4-[(2R)-methyl-3-(4-chlorophenyl)propiony...)
Show SMILES CC(C)C[C@H](N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C26H36ClN3O/c1-18(2)15-24(28)23-16-19(3)5-10-25(23)29-11-13-30(14-12-29)26(31)20(4)17-21-6-8-22(27)9-7-21/h5-10,16,18,20,24H,11-15,17,28H2,1-4H3/t20-,24+/m1/s1
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n/an/a 560n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha MSH-stimulated cAMP production in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM50190976
PNG
((1S)-[2-{4-[2-methyl-3-(2-methoxy-4-chlorophenyl)p...)
Show SMILES COc1cc(Cl)ccc1CC(C)C(=O)N1CCN(CC1)c1ccc(cc1[C@@H](N)CC(C)C)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O2/c1-17(2)13-23(32)22-15-20(27(29,30)31)6-8-24(22)33-9-11-34(12-10-33)26(35)18(3)14-19-5-7-21(28)16-25(19)36-4/h5-8,15-18,23H,9-14,32H2,1-4H3/t18?,23-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Activity at MC4R assessed as inhibition of alpha MSH-stimulated cAMP production in HEK293 cells


Bioorg Med Chem Lett 16: 4800-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.06.075
BindingDB Entry DOI: 10.7270/Q2NC60VS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%