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PubMed code 16919453

Compile data set for download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193645
PNG
((E)-N-(4-amino-2-sec-butylquinolin-6-yl)-3-(4-(tri...)
Show SMILES CCC(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-3-14(2)21-13-19(27)18-12-17(9-10-20(18)29-21)28-22(30)11-6-15-4-7-16(8-5-15)23(24,25)26/h4-14H,3H2,1-2H3,(H2,27,29)(H,28,30)/b11-6+
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n/an/a 0.300n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193637
PNG
((E)-N-(4-amino-2-tert-butylquinolin-6-yl)-3-(4-(tr...)
Show SMILES CC(C)(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-22(2,3)20-13-18(27)17-12-16(9-10-19(17)29-20)28-21(30)11-6-14-4-7-15(8-5-14)23(24,25)26/h4-13H,1-3H3,(H2,27,29)(H,28,30)/b11-6+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193606
PNG
(CHEMBL385957 | N-(4-amino-2-propylquinolin-6-yl)-4...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C25H22ClN3O/c1-2-3-20-15-23(27)22-14-21(12-13-24(22)28-20)29-25(30)18-6-4-16(5-7-18)17-8-10-19(26)11-9-17/h4-15H,2-3H2,1H3,(H2,27,28)(H,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193638
PNG
((E)-N-(4-amino-2-cyclopentylquinolin-6-yl)-3-(4-(t...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)C1CCCC1
Show InChI InChI=1S/C24H22F3N3O/c25-24(26,27)17-8-5-15(6-9-17)7-12-23(31)29-18-10-11-21-19(13-18)20(28)14-22(30-21)16-3-1-2-4-16/h5-14,16H,1-4H2,(H2,28,30)(H,29,31)/b12-7+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193651
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(biphenyl-...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C27H25N3O/c1-2-6-22-18-25(28)24-17-23(14-15-26(24)29-22)30-27(31)16-11-19-9-12-21(13-10-19)20-7-4-3-5-8-20/h3-5,7-18H,2,6H2,1H3,(H2,28,29)(H,30,31)/b16-11+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193605
PNG
((E)-N-(4-amino-2-pentylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES CCCCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-2-3-4-5-18-15-21(28)20-14-19(11-12-22(20)29-18)30-23(31)13-8-16-6-9-17(10-7-16)24(25,26)27/h6-15H,2-5H2,1H3,(H2,28,29)(H,30,31)/b13-8+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193636
PNG
((E)-N-(4-amino-2-ethylquinolin-6-yl)-3-(4-(trifluo...)
Show SMILES CCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C21H18F3N3O/c1-2-15-12-18(25)17-11-16(8-9-19(17)26-15)27-20(28)10-5-13-3-6-14(7-4-13)21(22,23)24/h3-12H,2H2,1H3,(H2,25,26)(H,27,28)/b10-5+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193635
PNG
((E)-N-(4-amino-2-cyclohexylquinolin-6-yl)-3-(4-(tr...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)C1CCCCC1
Show InChI InChI=1S/C25H24F3N3O/c26-25(27,28)18-9-6-16(7-10-18)8-13-24(32)30-19-11-12-22-20(14-19)21(29)15-23(31-22)17-4-2-1-3-5-17/h6-15,17H,1-5H2,(H2,29,31)(H,30,32)/b13-8+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193641
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-ethylph...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(CC)cc3)ccc2n1
Show InChI InChI=1S/C23H25N3O/c1-3-5-18-15-21(24)20-14-19(11-12-22(20)25-18)26-23(27)13-10-17-8-6-16(4-2)7-9-17/h6-15H,3-5H2,1-2H3,(H2,24,25)(H,26,27)/b13-10+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193647
PNG
((E)-N-(4-(methylamino)-2-propylquinolin-6-yl)-3-(4...)
Show SMILES CCCc1cc(NC)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-3-4-17-14-21(27-2)19-13-18(10-11-20(19)28-17)29-22(30)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-14H,3-4H2,1-2H3,(H,27,28)(H,29,30)/b12-7+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193653
PNG
((E)-N-(4-amino-2-butylquinolin-6-yl)-3-(4-(trifluo...)
Show SMILES CCCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-2-3-4-17-14-20(27)19-13-18(10-11-21(19)28-17)29-22(30)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-14H,2-4H2,1H3,(H2,27,28)(H,29,30)/b12-7+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193620
PNG
((E)-N-(4-amino-2-cyclobutylquinolin-6-yl)-3-(4-(tr...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)C1CCC1
Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)16-7-4-14(5-8-16)6-11-22(30)28-17-9-10-20-18(12-17)19(27)13-21(29-20)15-2-1-3-15/h4-13,15H,1-3H2,(H2,27,29)(H,28,30)/b11-6+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193603
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H20F3N3O/c1-2-3-16-13-19(26)18-12-17(9-10-20(18)27-16)28-21(29)11-6-14-4-7-15(8-5-14)22(23,24)25/h4-13H,2-3H2,1H3,(H2,26,27)(H,28,29)/b11-6+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193603
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H20F3N3O/c1-2-3-16-13-19(26)18-12-17(9-10-20(18)27-16)28-21(29)11-6-14-4-7-15(8-5-14)22(23,24)25/h4-13H,2-3H2,1H3,(H2,26,27)(H,28,29)/b11-6+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193613
PNG
((E)-N-(4-amino-2-isopropylquinolin-6-yl)-3-(4-(tri...)
Show SMILES CC(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H20F3N3O/c1-13(2)20-12-18(26)17-11-16(8-9-19(17)28-20)27-21(29)10-5-14-3-6-15(7-4-14)22(23,24)25/h3-13H,1-2H3,(H2,26,28)(H,27,29)/b10-5+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193630
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-iodophe...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(I)cc3)ccc2n1
Show InChI InChI=1S/C21H20IN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193643
PNG
((E)-N-(4-(azetidin-1-yl)-2-propylquinolin-6-yl)-3-...)
Show SMILES CCCc1cc(N2CCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C25H24F3N3O/c1-2-4-19-16-23(31-13-3-14-31)21-15-20(10-11-22(21)29-19)30-24(32)12-7-17-5-8-18(9-6-17)25(26,27)28/h5-12,15-16H,2-4,13-14H2,1H3,(H,30,32)/b12-7+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193610
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-isoprop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(C)C)ccc2n1
Show InChI InChI=1S/C24H27N3O/c1-4-5-19-15-22(25)21-14-20(11-12-23(21)26-19)27-24(28)13-8-17-6-9-18(10-7-17)16(2)3/h6-16H,4-5H2,1-3H3,(H2,25,26)(H,27,28)/b13-8+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241093
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-bromoph...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Br)cc3)ccc2n1
Show InChI InChI=1S/C21H20BrN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193652
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-propylp...)
Show SMILES CCCc1ccc(\C=C\C(=O)Nc2ccc3nc(CCC)cc(N)c3c2)cc1
Show InChI InChI=1S/C24H27N3O/c1-3-5-17-7-9-18(10-8-17)11-14-24(28)27-20-12-13-23-21(15-20)22(25)16-19(26-23)6-4-2/h7-16H,3-6H2,1-2H3,(H2,25,26)(H,27,28)/b14-11+
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193634
PNG
(CHEMBL214888 | N-(4-amino-2-propylquinolin-6-yl)-4...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)C3CCC(CC3)c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C25H28ClN3O/c1-2-3-20-15-23(27)22-14-21(12-13-24(22)28-20)29-25(30)18-6-4-16(5-7-18)17-8-10-19(26)11-9-17/h8-16,18H,2-7H2,1H3,(H2,27,28)(H,29,30)
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n/an/a 4.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193640
PNG
(CHEMBL215258 | N-(4-amino-2-propylquinolin-6-yl)-4...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H22F3N3O/c1-2-3-20-15-23(30)22-14-21(12-13-24(22)31-20)32-25(33)18-6-4-16(5-7-18)17-8-10-19(11-9-17)26(27,28)29/h4-15H,2-3H2,1H3,(H2,30,31)(H,32,33)
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n/an/a 4.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193650
PNG
((E)-N-(4-(ethylamino)-2-propylquinolin-6-yl)-3-(4-...)
Show SMILES CCCc1cc(NCC)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-3-5-18-15-22(28-4-2)20-14-19(11-12-21(20)29-18)30-23(31)13-8-16-6-9-17(10-7-16)24(25,26)27/h6-15H,3-5H2,1-2H3,(H,28,29)(H,30,31)/b13-8+
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n/an/a 4.80n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193617
PNG
((E)-N-(4-amino-2-neopentylquinolin-6-yl)-3-(4-(tri...)
Show SMILES CC(C)(C)Cc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-23(2,3)14-18-13-20(28)19-12-17(9-10-21(19)29-18)30-22(31)11-6-15-4-7-16(8-5-15)24(25,26)27/h4-13H,14H2,1-3H3,(H2,28,29)(H,30,31)/b11-6+
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n/an/a 5.80n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193615
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-chlorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C21H20ClN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241094
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2,4-dichl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H19Cl2N3O/c1-2-3-15-12-19(24)17-11-16(7-8-20(17)25-15)26-21(27)9-5-13-4-6-14(22)10-18(13)23/h4-12H,2-3H2,1H3,(H2,24,25)(H,26,27)/b9-5+
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n/an/a 6.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193649
PNG
((E)-N-(4-amino-2-methylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES Cc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C20H16F3N3O/c1-12-10-17(24)16-11-15(7-8-18(16)25-12)26-19(27)9-4-13-2-5-14(6-3-13)20(21,22)23/h2-11H,1H3,(H2,24,25)(H,26,27)/b9-4+
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n/an/a 8n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193626
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-p-tolylacr...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(C)cc3)ccc2n1
Show InChI InChI=1S/C22H23N3O/c1-3-4-17-14-20(23)19-13-18(10-11-21(19)24-17)25-22(26)12-9-16-7-5-15(2)6-8-16/h5-14H,3-4H2,1-2H3,(H2,23,24)(H,25,26)/b12-9+
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n/an/a 9n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193622
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-(methyl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(SC)cc3)ccc2n1
Show InChI InChI=1S/C22H23N3OS/c1-3-4-16-14-20(23)19-13-17(8-11-21(19)24-16)25-22(26)12-7-15-5-9-18(27-2)10-6-15/h5-14H,3-4H2,1-2H3,(H2,23,24)(H,25,26)/b12-7+
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n/an/a 9n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193624
PNG
(CHEMBL424721 | N-(4-amino-2-propylquinolin-6-yl)-3...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H22F3N3O/c1-2-3-16-13-19(26)18-12-17(9-10-20(18)27-16)28-21(29)11-6-14-4-7-15(8-5-14)22(23,24)25/h4-5,7-10,12-13H,2-3,6,11H2,1H3,(H2,26,27)(H,28,29)
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n/an/a 13n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193621
PNG
((E)-N-(2-propyl-4-(pyrrolidin-1-yl)quinolin-6-yl)-...)
Show SMILES CCCc1cc(N2CCCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H26F3N3O/c1-2-5-20-17-24(32-14-3-4-15-32)22-16-21(11-12-23(22)30-20)31-25(33)13-8-18-6-9-19(10-7-18)26(27,28)29/h6-13,16-17H,2-5,14-15H2,1H3,(H,31,33)/b13-8+
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193608
PNG
((E)-N-(4-(cyclobutylamino)-2-propylquinolin-6-yl)-...)
Show SMILES CCCc1cc(NC2CCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H26F3N3O/c1-2-4-20-16-24(30-19-5-3-6-19)22-15-21(12-13-23(22)31-20)32-25(33)14-9-17-7-10-18(11-8-17)26(27,28)29/h7-16,19H,2-6H2,1H3,(H,30,31)(H,32,33)/b14-9+
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n/an/a 18n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193629
PNG
((E)-N-(4-amino-2-phenylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)-c1ccccc1
Show InChI InChI=1S/C25H18F3N3O/c26-25(27,28)18-9-6-16(7-10-18)8-13-24(32)30-19-11-12-22-20(14-19)21(29)15-23(31-22)17-4-2-1-3-5-17/h1-15H,(H2,29,31)(H,30,32)/b13-8+
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n/an/a 19n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193618
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-nitroph...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)[N+]([O-])=O)ccc2n1
Show InChI InChI=1S/C21H20N4O3/c1-2-3-15-13-19(22)18-12-16(7-10-20(18)23-15)24-21(26)11-6-14-4-8-17(9-5-14)25(27)28/h4-13H,2-3H2,1H3,(H2,22,23)(H,24,26)/b11-6+
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193616
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-tert-bu...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(C)(C)C)ccc2n1
Show InChI InChI=1S/C25H29N3O/c1-5-6-19-16-22(26)21-15-20(12-13-23(21)27-19)28-24(29)14-9-17-7-10-18(11-8-17)25(2,3)4/h7-16H,5-6H2,1-4H3,(H2,26,27)(H,28,29)/b14-9+
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n/an/a 22n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193639
PNG
((E)-N-(4-methoxy-2-propylquinolin-6-yl)-3-(4-(trif...)
Show SMILES CCCc1cc(OC)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H21F3N2O2/c1-3-4-17-14-21(30-2)19-13-18(10-11-20(19)27-17)28-22(29)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-14H,3-4H2,1-2H3,(H,28,29)/b12-7+
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n/an/a 26n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193627
PNG
(1-(4-amino-2-propylquinolin-6-yl)-3-(4-(trifluorom...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)NCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C21H21F3N4O/c1-2-3-15-11-18(25)17-10-16(8-9-19(17)27-15)28-20(29)26-12-13-4-6-14(7-5-13)21(22,23)24/h4-11H,2-3,12H2,1H3,(H2,25,27)(H2,26,28,29)
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n/an/a 38n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241103
PNG
((E)-N-(4-(cyclopropylamino)-2-propylquinolin-6-yl)...)
Show SMILES CCCc1cc(NC2CC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C25H24F3N3O/c1-2-3-19-15-23(29-18-9-10-18)21-14-20(11-12-22(21)30-19)31-24(32)13-6-16-4-7-17(8-5-16)25(26,27)28/h4-8,11-15,18H,2-3,9-10H2,1H3,(H,29,30)(H,31,32)/b13-6+
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n/an/a 40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193611
PNG
((E)-N-(4-(dimethylamino)-2-propylquinolin-6-yl)-3-...)
Show SMILES CCCc1cc(N(C)C)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-4-5-18-15-22(30(2)3)20-14-19(11-12-21(20)28-18)29-23(31)13-8-16-6-9-17(10-7-16)24(25,26)27/h6-15H,4-5H2,1-3H3,(H,29,31)/b13-8+
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n/an/a 43n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193646
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-butylph...)
Show SMILES CCCCc1ccc(\C=C\C(=O)Nc2ccc3nc(CCC)cc(N)c3c2)cc1
Show InChI InChI=1S/C25H29N3O/c1-3-5-7-18-8-10-19(11-9-18)12-15-25(29)28-21-13-14-24-22(16-21)23(26)17-20(27-24)6-4-2/h8-17H,3-7H2,1-2H3,(H2,26,27)(H,28,29)/b15-12+
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n/an/a 45n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193628
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(3,4-dichl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)c(Cl)c3)ccc2n1
Show InChI InChI=1S/C21H19Cl2N3O/c1-2-3-14-12-19(24)16-11-15(6-8-20(16)25-14)26-21(27)9-5-13-4-7-17(22)18(23)10-13/h4-12H,2-3H2,1H3,(H2,24,25)(H,26,27)/b9-5+
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n/an/a 60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193604
PNG
((E)-4-(3-(4-amino-2-propylquinolin-6-ylamino)-3-ox...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(OC(C)=O)cc3)ccc2n1
Show InChI InChI=1S/C23H23N3O3/c1-3-4-17-14-21(24)20-13-18(8-11-22(20)25-17)26-23(28)12-7-16-5-9-19(10-6-16)29-15(2)27/h5-14H,3-4H2,1-2H3,(H2,24,25)(H,26,28)/b12-7+
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n/an/a 95n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193623
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2-chlorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3Cl)ccc2n1
Show InChI InChI=1S/C21H20ClN3O/c1-2-5-15-13-19(23)17-12-16(9-10-20(17)24-15)25-21(26)11-8-14-6-3-4-7-18(14)22/h3-4,6-13H,2,5H2,1H3,(H2,23,24)(H,25,26)/b11-8+
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n/an/a 120n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193609
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-fluorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(F)cc3)ccc2n1
Show InChI InChI=1S/C21H20FN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193625
PNG
(2-propyl-N6-(3-(4-(trifluoromethyl)phenyl)propyl)q...)
Show SMILES CCCc1cc(N)c2cc(NCCCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H24F3N3/c1-2-4-18-14-20(26)19-13-17(10-11-21(19)28-18)27-12-3-5-15-6-8-16(9-7-15)22(23,24)25/h6-11,13-14,27H,2-5,12H2,1H3,(H2,26,28)
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n/an/a 180n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193632
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-aminoph...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(N)cc3)ccc2n1
Show InChI InChI=1S/C21H22N4O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3,22H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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n/an/a 190n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
GPR145


(Homo sapiens (Human))
BDBM50193608
PNG
((E)-N-(4-(cyclobutylamino)-2-propylquinolin-6-yl)-...)
Show SMILES CCCc1cc(NC2CCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H26F3N3O/c1-2-4-20-16-24(30-19-5-3-6-19)22-15-21(12-13-23(22)31-20)32-25(33)14-9-17-7-10-18(11-8-17)26(27,28)29/h7-16,19H,2-6H2,1H3,(H,30,31)(H,32,33)/b14-9+
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n/an/a 960n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R2


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241092
PNG
(CHEMBL385639 | N-(4-amino-2-propylquinolin-6-yl)ci...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3)ccc2n1
Show InChI InChI=1S/C21H21N3O/c1-2-6-16-14-19(22)18-13-17(10-11-20(18)23-16)24-21(25)12-9-15-7-4-3-5-8-15/h3-5,7-14H,2,6H2,1H3,(H2,22,23)(H,24,25)/b12-9+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193619
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-hydroxy...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(O)cc3)ccc2n1
Show InChI InChI=1S/C21H21N3O2/c1-2-3-15-13-19(22)18-12-16(7-10-20(18)23-15)24-21(26)11-6-14-4-8-17(25)9-5-14/h4-13,25H,2-3H2,1H3,(H2,22,23)(H,24,26)/b11-6+
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193631
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(3-chlorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3cccc(Cl)c3)ccc2n1
Show InChI InChI=1S/C21H20ClN3O/c1-2-4-16-13-19(23)18-12-17(8-9-20(18)24-16)25-21(26)10-7-14-5-3-6-15(22)11-14/h3,5-13H,2,4H2,1H3,(H2,23,24)(H,25,26)/b10-7+
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193642
PNG
((E)-N-(4-(diethylamino)-2-propylquinolin-6-yl)-3-(...)
Show SMILES CCCc1cc(N(CC)CC)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H28F3N3O/c1-4-7-20-17-24(32(5-2)6-3)22-16-21(13-14-23(22)30-20)31-25(33)15-10-18-8-11-19(12-9-18)26(27,28)29/h8-17H,4-7H2,1-3H3,(H,31,33)/b15-10+
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193648
PNG
(CHEMBL385361 | N-(4-amino-2-propylquinolin-6-yl)-N...)
Show SMILES CCCc1cc(N)c2cc(ccc2n1)N(C)C(=O)CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O/c1-3-4-17-13-20(27)19-14-18(10-11-21(19)28-17)29(2)22(30)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3,(H2,27,28)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193644
PNG
(4-amino-2-propyl-N-(4-(trifluoromethyl)phenethyl)q...)
Show SMILES CCCc1cc(N)c2cc(ccc2n1)C(=O)NCCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H22F3N3O/c1-2-3-17-13-19(26)18-12-15(6-9-20(18)28-17)21(29)27-11-10-14-4-7-16(8-5-14)22(23,24)25/h4-9,12-13H,2-3,10-11H2,1H3,(H2,26,28)(H,27,29)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193633
PNG
(CHEMBL386509 | N-(4-amino-2-propylquinolin-6-yl)-2...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)Cc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C21H20F3N3O/c1-2-3-15-12-18(25)17-11-16(8-9-19(17)26-15)27-20(28)10-13-4-6-14(7-5-13)21(22,23)24/h4-9,11-12H,2-3,10H2,1H3,(H2,25,26)(H,27,28)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193607
PNG
((E)-N-(4-(piperidin-1-yl)-2-propylquinolin-6-yl)-3...)
Show SMILES CCCc1cc(N2CCCCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C27H28F3N3O/c1-2-6-21-18-25(33-15-4-3-5-16-33)23-17-22(12-13-24(23)31-21)32-26(34)14-9-19-7-10-20(11-8-19)27(28,29)30/h7-14,17-18H,2-6,15-16H2,1H3,(H,32,34)/b14-9+
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n/an/a>4.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193614
PNG
(CHEMBL215955 | N-(4-amino-2-propylquinolin-6-yl)-3...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)CCc3ccccc3)ccc2n1
Show InChI InChI=1S/C21H23N3O/c1-2-6-16-14-19(22)18-13-17(10-11-20(18)23-16)24-21(25)12-9-15-7-4-3-5-8-15/h3-5,7-8,10-11,13-14H,2,6,9,12H2,1H3,(H2,22,23)(H,24,25)
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n/an/a 8.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193612
PNG
(CHEMBL214936 | N-(4-amino-2-propylquinolin-6-yl)-4...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C20H18F3N3O/c1-2-3-14-11-17(24)16-10-15(8-9-18(16)25-14)26-19(27)12-4-6-13(7-5-12)20(21,22)23/h4-11H,2-3H2,1H3,(H2,24,25)(H,26,27)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193637
PNG
((E)-N-(4-amino-2-tert-butylquinolin-6-yl)-3-(4-(tr...)
Show SMILES CC(C)(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-22(2,3)20-13-18(27)17-12-16(9-10-19(17)29-20)28-21(30)11-6-14-4-7-15(8-5-14)23(24,25)26/h4-13H,1-3H3,(H2,27,29)(H,28,30)/b11-6+
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n/an/an/an/a 29n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193605
PNG
((E)-N-(4-amino-2-pentylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES CCCCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-2-3-4-5-18-15-21(28)20-14-19(11-12-22(20)29-18)30-23(31)13-8-16-6-9-17(10-7-16)24(25,26)27/h6-15H,2-5H2,1H3,(H2,28,29)(H,30,31)/b13-8+
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n/an/an/an/a 90n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193626
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-p-tolylacr...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(C)cc3)ccc2n1
Show InChI InChI=1S/C22H23N3O/c1-3-4-17-14-20(23)19-13-18(10-11-21(19)24-17)25-22(26)12-9-16-7-5-15(2)6-8-16/h5-14H,3-4H2,1-2H3,(H2,23,24)(H,25,26)/b12-9+
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n/an/an/an/a 71n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193627
PNG
(1-(4-amino-2-propylquinolin-6-yl)-3-(4-(trifluorom...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)NCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C21H21F3N4O/c1-2-3-15-11-18(25)17-10-16(8-9-19(17)27-15)28-20(29)26-12-13-4-6-14(7-5-13)21(22,23)24/h4-11H,2-3,12H2,1H3,(H2,25,27)(H2,26,28,29)
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n/an/an/an/a 380n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193653
PNG
((E)-N-(4-amino-2-butylquinolin-6-yl)-3-(4-(trifluo...)
Show SMILES CCCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-2-3-4-17-14-20(27)19-13-18(10-11-21(19)28-17)29-22(30)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-14H,2-4H2,1H3,(H2,27,28)(H,29,30)/b12-7+
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n/an/an/an/a 210n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241094
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2,4-dichl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3Cl)ccc2n1
Show InChI InChI=1S/C21H19Cl2N3O/c1-2-3-15-12-19(24)17-11-16(7-8-20(17)25-15)26-21(27)9-5-13-4-6-14(22)10-18(13)23/h4-12H,2-3H2,1H3,(H2,24,25)(H,26,27)/b9-5+
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n/an/an/an/a 904n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193638
PNG
((E)-N-(4-amino-2-cyclopentylquinolin-6-yl)-3-(4-(t...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)C1CCCC1
Show InChI InChI=1S/C24H22F3N3O/c25-24(26,27)17-8-5-15(6-9-17)7-12-23(31)29-18-10-11-21-19(13-18)20(28)14-22(30-21)16-3-1-2-4-16/h5-14,16H,1-4H2,(H2,28,30)(H,29,31)/b12-7+
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n/an/an/an/a 68n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193641
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-ethylph...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(CC)cc3)ccc2n1
Show InChI InChI=1S/C23H25N3O/c1-3-5-18-15-21(24)20-14-19(11-12-22(20)25-18)26-23(27)13-10-17-8-6-16(4-2)7-9-17/h6-15H,3-5H2,1-2H3,(H2,24,25)(H,26,27)/b13-10+
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n/an/an/an/a 160n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193624
PNG
(CHEMBL424721 | N-(4-amino-2-propylquinolin-6-yl)-3...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H22F3N3O/c1-2-3-16-13-19(26)18-12-17(9-10-20(18)27-16)28-21(29)11-6-14-4-7-15(8-5-14)22(23,24)25/h4-5,7-10,12-13H,2-3,6,11H2,1H3,(H2,26,27)(H,28,29)
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n/an/an/an/a 120n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193622
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-(methyl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(SC)cc3)ccc2n1
Show InChI InChI=1S/C22H23N3OS/c1-3-4-16-14-20(23)19-13-17(8-11-21(19)24-16)25-22(26)12-7-15-5-9-18(27-2)10-6-15/h5-14H,3-4H2,1-2H3,(H2,23,24)(H,25,26)/b12-7+
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n/an/an/an/a 71n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193604
PNG
((E)-4-(3-(4-amino-2-propylquinolin-6-ylamino)-3-ox...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(OC(C)=O)cc3)ccc2n1
Show InChI InChI=1S/C23H23N3O3/c1-3-4-17-14-21(24)20-13-18(8-11-22(20)25-17)26-23(28)12-7-16-5-9-19(10-6-16)29-15(2)27/h5-14H,3-4H2,1-2H3,(H2,24,25)(H,26,28)/b12-7+
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n/an/an/an/a 630n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193606
PNG
(CHEMBL385957 | N-(4-amino-2-propylquinolin-6-yl)-4...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C25H22ClN3O/c1-2-3-20-15-23(27)22-14-21(12-13-24(22)28-20)29-25(30)18-6-4-16(5-7-18)17-8-10-19(26)11-9-17/h4-15H,2-3H2,1H3,(H2,27,28)(H,29,30)
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n/an/an/an/a 75n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193610
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-isoprop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(C)C)ccc2n1
Show InChI InChI=1S/C24H27N3O/c1-4-5-19-15-22(25)21-14-20(11-12-23(21)26-19)27-24(28)13-8-17-6-9-18(10-7-17)16(2)3/h6-16H,4-5H2,1-3H3,(H2,25,26)(H,27,28)/b13-8+
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n/an/an/an/a 520n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193608
PNG
((E)-N-(4-(cyclobutylamino)-2-propylquinolin-6-yl)-...)
Show SMILES CCCc1cc(NC2CCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H26F3N3O/c1-2-4-20-16-24(30-19-5-3-6-19)22-15-21(12-13-23(22)31-20)32-25(33)14-9-17-7-10-18(11-8-17)26(27,28)29/h7-16,19H,2-6H2,1H3,(H,30,31)(H,32,33)/b14-9+
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n/an/an/an/a 270n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193603
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H20F3N3O/c1-2-3-16-13-19(26)18-12-17(9-10-20(18)27-16)28-21(29)11-6-14-4-7-15(8-5-14)22(23,24)25/h4-13H,2-3H2,1H3,(H2,26,27)(H,28,29)/b11-6+
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n/an/an/an/a 40n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193630
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-iodophe...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(I)cc3)ccc2n1
Show InChI InChI=1S/C21H20IN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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n/an/an/an/a 280n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193635
PNG
((E)-N-(4-amino-2-cyclohexylquinolin-6-yl)-3-(4-(tr...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)C1CCCCC1
Show InChI InChI=1S/C25H24F3N3O/c26-25(27,28)18-9-6-16(7-10-18)8-13-24(32)30-19-11-12-22-20(14-19)21(29)15-23(31-22)17-4-2-1-3-5-17/h6-15,17H,1-5H2,(H2,29,31)(H,30,32)/b13-8+
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n/an/an/an/a 96n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193618
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-nitroph...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)[N+]([O-])=O)ccc2n1
Show InChI InChI=1S/C21H20N4O3/c1-2-3-15-13-19(22)18-12-16(7-10-20(18)23-15)24-21(26)11-6-14-4-8-17(9-5-14)25(27)28/h4-13H,2-3H2,1H3,(H2,22,23)(H,24,26)/b11-6+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193649
PNG
((E)-N-(4-amino-2-methylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES Cc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C20H16F3N3O/c1-12-10-17(24)16-11-15(7-8-18(16)25-12)26-19(27)9-4-13-2-5-14(6-3-13)20(21,22)23/h2-11H,1H3,(H2,24,25)(H,26,27)/b9-4+
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n/an/an/an/a 140n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193647
PNG
((E)-N-(4-(methylamino)-2-propylquinolin-6-yl)-3-(4...)
Show SMILES CCCc1cc(NC)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-3-4-17-14-21(27-2)19-13-18(10-11-20(19)28-17)29-22(30)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-14H,3-4H2,1-2H3,(H,27,28)(H,29,30)/b12-7+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193651
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(biphenyl-...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)-c3ccccc3)ccc2n1
Show InChI InChI=1S/C27H25N3O/c1-2-6-22-18-25(28)24-17-23(14-15-26(24)29-22)30-27(31)16-11-19-9-12-21(13-10-19)20-7-4-3-5-8-20/h3-5,7-18H,2,6H2,1H3,(H2,28,29)(H,30,31)/b16-11+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193650
PNG
((E)-N-(4-(ethylamino)-2-propylquinolin-6-yl)-3-(4-...)
Show SMILES CCCc1cc(NCC)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-3-5-18-15-22(28-4-2)20-14-19(11-12-21(20)29-18)30-23(31)13-8-16-6-9-17(10-7-16)24(25,26)27/h6-15H,3-5H2,1-2H3,(H,28,29)(H,30,31)/b13-8+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193645
PNG
((E)-N-(4-amino-2-sec-butylquinolin-6-yl)-3-(4-(tri...)
Show SMILES CCC(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H22F3N3O/c1-3-14(2)21-13-19(27)18-12-17(9-10-20(18)29-21)28-22(30)11-6-15-4-7-16(8-5-15)23(24,25)26/h4-14H,3H2,1-2H3,(H2,27,29)(H,28,30)/b11-6+
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n/an/an/an/a 44n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193639
PNG
((E)-N-(4-methoxy-2-propylquinolin-6-yl)-3-(4-(trif...)
Show SMILES CCCc1cc(OC)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H21F3N2O2/c1-3-4-17-14-21(30-2)19-13-18(10-11-20(19)27-17)28-22(29)12-7-15-5-8-16(9-6-15)23(24,25)26/h5-14H,3-4H2,1-2H3,(H,28,29)/b12-7+
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n/an/an/an/a 360n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193646
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-butylph...)
Show SMILES CCCCc1ccc(\C=C\C(=O)Nc2ccc3nc(CCC)cc(N)c3c2)cc1
Show InChI InChI=1S/C25H29N3O/c1-3-5-7-18-8-10-19(11-9-18)12-15-25(29)28-21-13-14-24-22(16-21)23(26)17-20(27-24)6-4-2/h8-17H,3-7H2,1-2H3,(H2,26,27)(H,28,29)/b15-12+
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n/an/an/an/a 740n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193652
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-propylp...)
Show SMILES CCCc1ccc(\C=C\C(=O)Nc2ccc3nc(CCC)cc(N)c3c2)cc1
Show InChI InChI=1S/C24H27N3O/c1-3-5-17-7-9-18(10-8-17)11-14-24(28)27-20-12-13-23-21(15-20)22(25)16-19(26-23)6-4-2/h7-16H,3-6H2,1-2H3,(H2,25,26)(H,27,28)/b14-11+
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n/an/an/an/a 3.60E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193625
PNG
(2-propyl-N6-(3-(4-(trifluoromethyl)phenyl)propyl)q...)
Show SMILES CCCc1cc(N)c2cc(NCCCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H24F3N3/c1-2-4-18-14-20(26)19-13-17(10-11-21(19)28-18)27-12-3-5-15-6-8-16(9-7-15)22(23,24)25/h6-11,13-14,27H,2-5,12H2,1H3,(H2,26,28)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193609
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-fluorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(F)cc3)ccc2n1
Show InChI InChI=1S/C21H20FN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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n/an/an/an/a 200n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193636
PNG
((E)-N-(4-amino-2-ethylquinolin-6-yl)-3-(4-(trifluo...)
Show SMILES CCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C21H18F3N3O/c1-2-15-12-18(25)17-11-16(8-9-19(17)26-15)27-20(28)10-5-13-3-6-14(7-4-13)21(22,23)24/h3-12H,2H2,1H3,(H2,25,26)(H,27,28)/b10-5+
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n/an/an/an/a 110n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50241093
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-bromoph...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Br)cc3)ccc2n1
Show InChI InChI=1S/C21H20BrN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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n/an/an/an/a 93n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193640
PNG
(CHEMBL215258 | N-(4-amino-2-propylquinolin-6-yl)-4...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)c3ccc(cc3)-c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H22F3N3O/c1-2-3-20-15-23(30)22-14-21(12-13-24(22)31-20)32-25(33)18-6-4-16(5-7-18)17-8-10-19(11-9-17)26(27,28)29/h4-15H,2-3H2,1H3,(H2,30,31)(H,32,33)
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n/an/an/an/a 310n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193617
PNG
((E)-N-(4-amino-2-neopentylquinolin-6-yl)-3-(4-(tri...)
Show SMILES CC(C)(C)Cc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-23(2,3)14-18-13-20(28)19-12-17(9-10-21(19)29-18)30-22(31)11-6-15-4-7-16(8-5-15)24(25,26)27/h4-13H,14H2,1-3H3,(H2,28,29)(H,30,31)/b11-6+
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n/an/an/an/a 110n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193620
PNG
((E)-N-(4-amino-2-cyclobutylquinolin-6-yl)-3-(4-(tr...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)C1CCC1
Show InChI InChI=1S/C23H20F3N3O/c24-23(25,26)16-7-4-14(5-8-16)6-11-22(30)28-17-9-10-20-18(12-17)19(27)13-21(29-20)15-2-1-3-15/h4-13,15H,1-3H2,(H2,27,29)(H,28,30)/b11-6+
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n/an/an/an/a 250n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193621
PNG
((E)-N-(2-propyl-4-(pyrrolidin-1-yl)quinolin-6-yl)-...)
Show SMILES CCCc1cc(N2CCCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H26F3N3O/c1-2-5-20-17-24(32-14-3-4-15-32)22-16-21(11-12-23(22)30-20)31-25(33)13-8-18-6-9-19(10-7-18)26(27,28)29/h6-13,16-17H,2-5,14-15H2,1H3,(H,31,33)/b13-8+
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n/an/an/an/a 2.80E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193643
PNG
((E)-N-(4-(azetidin-1-yl)-2-propylquinolin-6-yl)-3-...)
Show SMILES CCCc1cc(N2CCC2)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C25H24F3N3O/c1-2-4-19-16-23(31-13-3-14-31)21-15-20(10-11-22(21)29-19)30-24(32)12-7-17-5-8-18(9-6-17)25(26,27)28/h5-12,15-16H,2-4,13-14H2,1H3,(H,30,32)/b12-7+
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n/an/an/an/a 2.50E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193616
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-tert-bu...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(C)(C)C)ccc2n1
Show InChI InChI=1S/C25H29N3O/c1-5-6-19-16-22(26)21-15-20(12-13-23(21)27-19)28-24(29)14-9-17-7-10-18(11-8-17)25(2,3)4/h7-16H,5-6H2,1-4H3,(H2,26,27)(H,28,29)/b14-9+
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n/an/an/an/a 910n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193634
PNG
(CHEMBL214888 | N-(4-amino-2-propylquinolin-6-yl)-4...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)C3CCC(CC3)c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C25H28ClN3O/c1-2-3-20-15-23(27)22-14-21(12-13-24(22)28-20)29-25(30)18-6-4-16(5-7-18)17-8-10-19(26)11-9-17/h8-16,18H,2-7H2,1H3,(H2,27,28)(H,29,30)
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n/an/an/an/a 370n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193611
PNG
((E)-N-(4-(dimethylamino)-2-propylquinolin-6-yl)-3-...)
Show SMILES CCCc1cc(N(C)C)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-4-5-18-15-22(30(2)3)20-14-19(11-12-21(20)28-18)29-23(31)13-8-16-6-9-17(10-7-16)24(25,26)27/h6-15H,4-5H2,1-3H3,(H,29,31)/b13-8+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193628
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(3,4-dichl...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)c(Cl)c3)ccc2n1
Show InChI InChI=1S/C21H19Cl2N3O/c1-2-3-14-12-19(24)16-11-15(6-8-20(16)25-14)26-21(27)9-5-13-4-7-17(22)18(23)10-13/h4-12H,2-3H2,1H3,(H2,24,25)(H,26,27)/b9-5+
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n/an/an/an/a 990n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193615
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(4-chlorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccc(Cl)cc3)ccc2n1
Show InChI InChI=1S/C21H20ClN3O/c1-2-3-16-13-19(23)18-12-17(9-10-20(18)24-16)25-21(26)11-6-14-4-7-15(22)8-5-14/h4-13H,2-3H2,1H3,(H2,23,24)(H,25,26)/b11-6+
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n/an/an/an/a 96n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193613
PNG
((E)-N-(4-amino-2-isopropylquinolin-6-yl)-3-(4-(tri...)
Show SMILES CC(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H20F3N3O/c1-13(2)20-12-18(26)17-11-16(8-9-19(17)28-20)27-21(29)10-5-14-3-6-15(7-4-14)22(23,24)25/h3-13H,1-2H3,(H2,26,28)(H,27,29)/b10-5+
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n/an/an/an/a 160n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193629
PNG
((E)-N-(4-amino-2-phenylquinolin-6-yl)-3-(4-(triflu...)
Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)-c1ccccc1
Show InChI InChI=1S/C25H18F3N3O/c26-25(27,28)18-9-6-16(7-10-18)8-13-24(32)30-19-11-12-22-20(14-19)21(29)15-23(31-22)17-4-2-1-3-5-17/h1-15H,(H2,29,31)(H,30,32)/b13-8+
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n/an/an/an/a 6.60E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50193623
PNG
((E)-N-(4-amino-2-propylquinolin-6-yl)-3-(2-chlorop...)
Show SMILES CCCc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3Cl)ccc2n1
Show InChI InChI=1S/C21H20ClN3O/c1-2-5-15-13-19(23)17-12-16(9-10-20(17)24-15)25-21(26)11-8-14-6-3-4-7-18(14)22/h3-4,6-13H,2,5H2,1H3,(H2,23,24)(H,25,26)/b11-8+
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n/an/an/an/a 500n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing MCH-R1


Bioorg Med Chem Lett 16: 5275-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S
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Ligand-Target Pair
* indicates data uncertainty>20%