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PubMed code 16931012

Compile data set for download or QSAR
Found 61 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 1n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Yes


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 6n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193891
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(3-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(OCCN4CCCC4)c3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-8-6-9-20(2)26(19)22-16-21(3)27-25(17-22)31-32-28(30-27)29-23-10-7-11-24(18-23)34-15-14-33-12-4-5-13-33/h6-11,16-18H,4-5,12-15H2,1-3H3,(H,29,30,32)
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n/an/a 6n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 7n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193884
PNG
(CHEMBL221742 | N-(4-(7-(2,6-dimethylphenyl)-5-meth...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(NS(=O)(=O)CCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H32N6O2S/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)33-37(35,36)16-15-34-13-4-5-14-34/h6-12,17-18,33H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 9n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193879
PNG
(CHEMBL218656 | N-(4-(2-(diethylamino)ethoxy)phenyl...)
Show SMILES CCN(CC)CCOc1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C28H33N5O/c1-6-33(7-2)15-16-34-24-13-11-23(12-14-24)29-28-30-27-21(5)17-22(18-25(27)31-32-28)26-19(3)9-8-10-20(26)4/h8-14,17-18H,6-7,15-16H2,1-5H3,(H,29,30,32)
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n/an/a 10n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193910
PNG
(CHEMBL218102 | N-(3-(2-(diethylamino)ethoxy)phenyl...)
Show SMILES CCN(CC)CCOc1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1
Show InChI InChI=1S/C28H33N5O/c1-6-33(7-2)14-15-34-24-13-9-12-23(18-24)29-28-30-27-21(5)16-22(17-25(27)31-32-28)26-19(3)10-8-11-20(26)4/h8-13,16-18H,6-7,14-15H2,1-5H3,(H,29,30,32)
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n/an/a 10n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 13n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 20n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Abl


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 21n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193897
PNG
(7-(2,6-dimethylphenyl)-N-(4-(2-ethoxy-4-methylpipe...)
Show SMILES CCOC1CN(C)CCN1c1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C29H34N6O/c1-6-36-26-18-34(5)14-15-35(26)24-12-10-23(11-13-24)30-29-31-28-21(4)16-22(17-25(28)32-33-29)27-19(2)8-7-9-20(27)3/h7-13,16-17,26H,6,14-15,18H2,1-5H3,(H,30,31,33)
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n/an/a 21n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 23n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fyn


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193881
PNG
(CHEMBL220931 | N-(3-(7-(2,6-dimethylphenyl)-5-meth...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(NS(=O)(=O)CCN4CCCC4)c3)nnc2c1
Show InChI InChI=1S/C28H32N6O2S/c1-19-8-6-9-20(2)26(19)22-16-21(3)27-25(17-22)31-32-28(30-27)29-23-10-7-11-24(18-23)33-37(35,36)15-14-34-12-4-5-13-34/h6-11,16-18,33H,4-5,12-15H2,1-3H3,(H,29,30,32)
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n/an/a 26n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193903
PNG
(7-(2,6-dimethylphenyl)-N-(4-(2-ethoxymorpholino)ph...)
Show SMILES CCOC1CN(CCO1)c1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C28H31N5O2/c1-5-34-25-17-33(13-14-35-25)23-11-9-22(10-12-23)29-28-30-27-20(4)15-21(16-24(27)31-32-28)26-18(2)7-6-8-19(26)3/h6-12,15-16,25H,5,13-14,17H2,1-4H3,(H,29,30,32)
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n/an/a 32n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193909
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(4-methyl-2-p...)
Show SMILES CCCOC1CN(C)CCN1c1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C30H36N6O/c1-6-16-37-27-19-35(5)14-15-36(27)25-12-10-24(11-13-25)31-30-32-29-22(4)17-23(18-26(29)33-34-30)28-20(2)8-7-9-21(28)3/h7-13,17-18,27H,6,14-16,19H2,1-5H3,(H,31,32,34)
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n/an/a 36n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193907
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(pyridin-4-yl)be...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccncc3)nnc2c1
Show InChI InChI=1S/C21H19N5/c1-13-5-4-6-14(2)19(13)16-11-15(3)20-18(12-16)25-26-21(24-20)23-17-7-9-22-10-8-17/h4-12H,1-3H3,(H,22,23,24,26)
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n/an/a 40n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193890
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(3-(4-methyl-2-p...)
Show SMILES CCCOC1CN(C)CCN1c1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1
Show InChI InChI=1S/C30H36N6O/c1-6-15-37-27-19-35(5)13-14-36(27)25-12-8-11-24(18-25)31-30-32-29-22(4)16-23(17-26(29)33-34-30)28-20(2)9-7-10-21(28)3/h7-12,16-18,27H,6,13-15,19H2,1-5H3,(H,31,32,34)
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n/an/a 40n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193877
PNG
(7-(2,6-dimethylphenyl)-N-(3-(2-ethoxy-4-methylpipe...)
Show SMILES CCOC1CN(C)CCN1c1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1
Show InChI InChI=1S/C29H34N6O/c1-6-36-26-18-34(5)13-14-35(26)24-12-8-11-23(17-24)30-29-31-28-21(4)15-22(16-25(28)32-33-29)27-19(2)9-7-10-20(27)3/h7-12,15-17,26H,6,13-14,18H2,1-5H3,(H,30,31,33)
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n/an/a 41n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 64n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 68n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Raf1 kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193902
PNG
(7-(2,6-dimethylphenyl)-N-(4-ethoxyphenyl)-5-methyl...)
Show SMILES CCOc1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C24H24N4O/c1-5-29-20-11-9-19(10-12-20)25-24-26-23-17(4)13-18(14-21(23)27-28-24)22-15(2)7-6-8-16(22)3/h6-14H,5H2,1-4H3,(H,25,26,28)
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n/an/a 110n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193908
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(piperazin-1-...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(cc3)S(=O)(=O)N3CCNCC3)nnc2c1
Show InChI InChI=1S/C26H28N6O2S/c1-17-5-4-6-18(2)24(17)20-15-19(3)25-23(16-20)30-31-26(29-25)28-21-7-9-22(10-8-21)35(33,34)32-13-11-27-12-14-32/h4-10,15-16,27H,11-14H2,1-3H3,(H,28,29,31)
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n/an/a 128n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193892
PNG
(CHEMBL217961 | N-(3-chlorophenyl)-7-(2,6-dimethylp...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(Cl)c3)nnc2c1
Show InChI InChI=1S/C22H19ClN4/c1-13-6-4-7-14(2)20(13)16-10-15(3)21-19(11-16)26-27-22(25-21)24-18-9-5-8-17(23)12-18/h4-12H,1-3H3,(H,24,25,27)
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n/an/a 130n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193887
PNG
(7-(2,6-dimethylphenyl)-5,6-dimethyl-N-phenylbenzo[...)
Show SMILES Cc1cccc(C)c1-c1cc2nnc(Nc3ccccc3)nc2c(C)c1C
Show InChI InChI=1S/C23H22N4/c1-14-9-8-10-15(2)21(14)19-13-20-22(17(4)16(19)3)25-23(27-26-20)24-18-11-6-5-7-12-18/h5-13H,1-4H3,(H,24,25,27)
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n/an/a 130n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193915
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(4-methylpipe...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C27H30N6O2S/c1-18-6-5-7-19(2)25(18)21-16-20(3)26-24(17-21)30-31-27(29-26)28-22-8-10-23(11-9-22)36(34,35)33-14-12-32(4)13-15-33/h5-11,16-17H,12-15H2,1-4H3,(H,28,29,31)
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n/an/a 137n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193885
PNG
(7-(2,6-dimethylphenyl)-N-(4-methoxyphenyl)-5-methy...)
Show SMILES COc1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C23H22N4O/c1-14-6-5-7-15(2)21(14)17-12-16(3)22-20(13-17)26-27-23(25-22)24-18-8-10-19(28-4)11-9-18/h5-13H,1-4H3,(H,24,25,27)
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n/an/a 140n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193886
PNG
(3-(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]t...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(c3)S(N)(=O)=O)nnc2c1
Show InChI InChI=1S/C22H21N5O2S/c1-13-6-4-7-14(2)20(13)16-10-15(3)21-19(11-16)26-27-22(25-21)24-17-8-5-9-18(12-17)30(23,28)29/h4-12H,1-3H3,(H2,23,28,29)(H,24,25,27)
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n/an/a 140n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193898
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-m-tolylbenzo[e][...)
Show SMILES Cc1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1
Show InChI InChI=1S/C23H22N4/c1-14-7-5-10-19(11-14)24-23-25-22-17(4)12-18(13-20(22)26-27-23)21-15(2)8-6-9-16(21)3/h5-13H,1-4H3,(H,24,25,27)
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n/an/a 180n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193882
PNG
(CHEMBL220912 | N1-(7-(2,6-dimethylphenyl)-5-methyl...)
Show SMILES CN(C)c1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C24H25N5/c1-15-7-6-8-16(2)22(15)18-13-17(3)23-21(14-18)27-28-24(26-23)25-19-9-11-20(12-10-19)29(4)5/h6-14H,1-5H3,(H,25,26,28)
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n/an/a 240n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193894
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(3-(4-methylpipe...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1
Show InChI InChI=1S/C27H30N6O2S/c1-18-7-5-8-19(2)25(18)21-15-20(3)26-24(16-21)30-31-27(29-26)28-22-9-6-10-23(17-22)36(34,35)33-13-11-32(4)12-14-33/h5-10,15-17H,11-14H2,1-4H3,(H,28,29,31)
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n/an/a 320n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193889
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-phenylbenzo[e][1...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccccc3)nnc2c1
Show InChI InChI=1S/C22H20N4/c1-14-8-7-9-15(2)20(14)17-12-16(3)21-19(13-17)25-26-22(24-21)23-18-10-5-4-6-11-18/h4-13H,1-3H3,(H,23,24,26)
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n/an/a 410n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193901
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(3-(piperazin-1-...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(c3)S(=O)(=O)N3CCNCC3)nnc2c1
Show InChI InChI=1S/C26H28N6O2S/c1-17-6-4-7-18(2)24(17)20-14-19(3)25-23(15-20)30-31-26(29-25)28-21-8-5-9-22(16-21)35(33,34)32-12-10-27-11-13-32/h4-9,14-16,27H,10-13H2,1-3H3,(H,28,29,31)
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n/an/a 480n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 555n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase CSK


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 659n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSK


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 678n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193873
PNG
(7-(2,6-dimethylphenyl)-N-(3,4-dimethylphenyl)-5-me...)
Show SMILES Cc1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1C
Show InChI InChI=1S/C24H24N4/c1-14-9-10-20(12-17(14)4)25-24-26-23-18(5)11-19(13-21(23)27-28-24)22-15(2)7-6-8-16(22)3/h6-13H,1-5H3,(H,25,26,28)
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n/an/a 960n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 960n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 965n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 1.32E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Blk


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193883
PNG
(7-(2,6-dimethylphenyl)-N-phenylbenzo[e][1,2,4]tria...)
Show SMILES Cc1cccc(C)c1-c1ccc2nc(Nc3ccccc3)nnc2c1
Show InChI InChI=1S/C21H18N4/c1-14-7-6-8-15(2)20(14)16-11-12-18-19(13-16)24-25-21(23-18)22-17-9-4-3-5-10-17/h3-13H,1-2H3,(H,22,23,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193904
PNG
(3-(3-amino-5-methylbenzo[e][1,2,4]triazin-7-yl)-4-...)
Show SMILES Cc1cc(cc2nnc(N)nc12)-c1cc(O)ccc1Cl
Show InChI InChI=1S/C14H11ClN4O/c1-7-4-8(10-6-9(20)2-3-11(10)15)5-12-13(7)17-14(16)19-18-12/h2-6,20H,1H3,(H2,16,17,19)
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n/an/a 1.50E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193880
PNG
(CHEMBL218598 | N-(7-(2,6-dimethylphenyl)-5-methylb...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(NC(=O)c3ccccc3)nnc2c1
Show InChI InChI=1S/C23H20N4O/c1-14-8-7-9-15(2)20(14)18-12-16(3)21-19(13-18)26-27-23(24-21)25-22(28)17-10-5-4-6-11-17/h4-13H,1-3H3,(H,24,25,27,28)
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n/an/a 1.80E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193899
PNG
(7-(2,6-dimethylphenyl)benzo[e][1,2,4]triazin-3-ami...)
Show SMILES Cc1cccc(C)c1-c1ccc2nc(N)nnc2c1
Show InChI InChI=1S/C15H14N4/c1-9-4-3-5-10(2)14(9)11-6-7-12-13(8-11)18-19-15(16)17-12/h3-8H,1-2H3,(H2,16,17,19)
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n/an/a 2.20E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 2.71E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of p70S6K


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193916
PNG
(7-(2,6-dichlorophenyl)-5-methylbenzo[e][1,2,4]tria...)
Show SMILES Cc1cc(cc2nnc(N)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C14H10Cl2N4/c1-7-5-8(12-9(15)3-2-4-10(12)16)6-11-13(7)18-14(17)20-19-11/h2-6H,1H3,(H2,17,18,20)
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n/an/a 3.60E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193895
PNG
(7-(naphthalen-2-yl)benzo[e][1,2,4]triazin-3-amine ...)
Show SMILES Nc1nnc2cc(ccc2n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12N4/c18-17-19-15-8-7-14(10-16(15)20-21-17)13-6-5-11-3-1-2-4-12(11)9-13/h1-10H,(H2,18,19,21)
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n/an/a 5.20E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50193874
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(4-(2-(pyrrolidi...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1
Show InChI InChI=1S/C28H31N5O/c1-19-7-6-8-20(2)26(19)22-17-21(3)27-25(18-22)31-32-28(30-27)29-23-9-11-24(12-10-23)34-16-15-33-13-4-5-14-33/h6-12,17-18H,4-5,13-16H2,1-3H3,(H,29,30,32)
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n/an/a 5.99E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Abl T315I mutant


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193913
PNG
(7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]tria...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(N)nnc2c1
Show InChI InChI=1S/C16H16N4/c1-9-5-4-6-10(2)14(9)12-7-11(3)15-13(8-12)19-20-16(17)18-15/h4-8H,1-3H3,(H2,17,18,20)
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n/an/a 7.40E+3n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193912
PNG
(7-(benzo[d][1,3]dioxol-5-yl)benzo[e][1,2,4]triazin...)
Show SMILES Nc1nnc2cc(ccc2n1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C14H10N4O2/c15-14-16-10-3-1-8(5-11(10)17-18-14)9-2-4-12-13(6-9)20-7-19-12/h1-6H,7H2,(H2,15,16,18)
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n/an/a 1.20E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193876
PNG
(3-(3-aminobenzo[e][1,2,4]triazin-7-yl)phenol | CHE...)
Show SMILES Nc1nnc2cc(ccc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C13H10N4O/c14-13-15-11-5-4-9(7-12(11)16-17-13)8-2-1-3-10(18)6-8/h1-7,18H,(H2,14,15,17)
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n/an/a 1.20E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193900
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(quinolin-8-yl)b...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc4cccnc34)nnc2c1
Show InChI InChI=1S/C25H21N5/c1-15-7-4-8-16(2)22(15)19-13-17(3)23-21(14-19)29-30-25(28-23)27-20-11-5-9-18-10-6-12-26-24(18)20/h4-14H,1-3H3,(H,27,28,30)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193906
PNG
(CHEMBL374868 | N-(2,5-dimethylphenyl)-7-(2,6-dimet...)
Show SMILES Cc1ccc(C)c(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1
Show InChI InChI=1S/C24H24N4/c1-14-9-10-15(2)20(11-14)25-24-26-23-18(5)12-19(13-21(23)27-28-24)22-16(3)7-6-8-17(22)4/h6-13H,1-5H3,(H,25,26,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193914
PNG
(CHEMBL441545 | N-(2,4-dimethylphenyl)-7-(2,6-dimet...)
Show SMILES Cc1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c(C)c1
Show InChI InChI=1S/C24H24N4/c1-14-9-10-20(17(4)11-14)25-24-26-23-18(5)12-19(13-21(23)27-28-24)22-15(2)7-6-8-16(22)3/h6-13H,1-5H3,(H,25,26,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193888
PNG
(CHEMBL218842 | N-(4-butylphenyl)-7-(2,6-dimethylph...)
Show SMILES CCCCc1ccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)cc1
Show InChI InChI=1S/C26H28N4/c1-5-6-10-20-11-13-22(14-12-20)27-26-28-25-19(4)15-21(16-23(25)29-30-26)24-17(2)8-7-9-18(24)3/h7-9,11-16H,5-6,10H2,1-4H3,(H,27,28,30)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193917
PNG
(7-(2-chlorophenyl)-5-methylbenzo[e][1,2,4]triazin-...)
Show SMILES Cc1cc(cc2nnc(N)nc12)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN4/c1-8-6-9(10-4-2-3-5-11(10)15)7-12-13(8)17-14(16)19-18-12/h2-7H,1H3,(H2,16,17,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193905
PNG
(7-phenylbenzo[e][1,2,4]triazin-3-amine | CHEMBL218...)
Show SMILES Nc1nnc2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C13H10N4/c14-13-15-11-7-6-10(8-12(11)16-17-13)9-4-2-1-3-5-9/h1-8H,(H2,14,15,17)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193911
PNG
(7-(2,6-dimethylphenyl)-N-(2-methoxyphenyl)-5-methy...)
Show SMILES COc1ccccc1Nc1nnc2cc(cc(C)c2n1)-c1c(C)cccc1C
Show InChI InChI=1S/C23H22N4O/c1-14-8-7-9-15(2)21(14)17-12-16(3)22-19(13-17)26-27-23(25-22)24-18-10-5-6-11-20(18)28-4/h5-13H,1-4H3,(H,24,25,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193875
PNG
(CHEMBL218551 | N-(2,3-dimethylphenyl)-7-(2,6-dimet...)
Show SMILES Cc1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1C
Show InChI InChI=1S/C24H24N4/c1-14-8-7-11-20(18(14)5)25-24-26-23-17(4)12-19(13-21(23)27-28-24)22-15(2)9-6-10-16(22)3/h6-13H,1-5H3,(H,25,26,28)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193878
PNG
(7-(2,6-dimethylphenyl)-5-methyl-N-(pyridin-2-yl)be...)
Show SMILES Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccccn3)nnc2c1
Show InChI InChI=1S/C21H19N5/c1-13-7-6-8-14(2)19(13)16-11-15(3)20-17(12-16)25-26-21(24-20)23-18-9-4-5-10-22-18/h4-12H,1-3H3,(H,22,23,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193896
PNG
(CHEMBL221739 | N-(7-(2,6-dimethylphenyl)-5-methylb...)
Show SMILES CC(=O)Nc1nnc2cc(cc(C)c2n1)-c1c(C)cccc1C
Show InChI InChI=1S/C18H18N4O/c1-10-6-5-7-11(2)16(10)14-8-12(3)17-15(9-14)21-22-18(20-17)19-13(4)23/h5-9H,1-4H3,(H,19,20,22,23)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50193893
PNG
(7-mesityl-5-methyl-N-phenylbenzo[e][1,2,4]triazin-...)
Show SMILES Cc1cc(C)c(c(C)c1)-c1cc(C)c2nc(Nc3ccccc3)nnc2c1
Show InChI InChI=1S/C23H22N4/c1-14-10-15(2)21(16(3)11-14)18-12-17(4)22-20(13-18)26-27-23(25-22)24-19-8-6-5-7-9-19/h5-13H,1-4H3,(H,24,25,27)
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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src kinase


Bioorg Med Chem Lett 16: 5546-50 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.035
BindingDB Entry DOI: 10.7270/Q2SN08MP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%