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PubMed code 16942873

Compile data set for download or QSAR
Found 5 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1
Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
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Article
PubMed
234n/an/an/an/an/an/an/an/a



Universit£ di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]alpha-Bungarotoxin from alpha-7 nAChR in rat brain cortex membranes


Bioorg Med Chem Lett 16: 5610-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.020
BindingDB Entry DOI: 10.7270/Q28G8MH4
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50370829
PNG
(CHEMBL481368)
Show SMILES CN1CCC[C@H]1[C@@H]1COc2ccccc2O1
Show InChI InChI=1S/C13H17NO2/c1-14-8-4-5-10(14)13-9-15-11-6-2-3-7-12(11)16-13/h2-3,6-7,10,13H,4-5,8-9H2,1H3/t10-,13-/m0/s1
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PubMed
1.20E+4n/an/an/an/an/an/an/an/a



Universit£ di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]alpha-Bungarotoxin from alpha-7 nAChR in rat brain cortex membranes


Bioorg Med Chem Lett 16: 5610-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.020
BindingDB Entry DOI: 10.7270/Q28G8MH4
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50370830
PNG
(CHEMBL481374)
Show SMILES CN1CCC[C@@H]1[C@H]1COc2ccccc2O1
Show InChI InChI=1S/C13H17NO2/c1-14-8-4-5-10(14)13-9-15-11-6-2-3-7-12(11)16-13/h2-3,6-7,10,13H,4-5,8-9H2,1H3/t10-,13-/m1/s1
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PubMed
4.50E+4n/an/an/an/an/an/an/an/a



Universit£ di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]alpha-Bungarotoxin from alpha-7 nAChR in rat brain cortex membranes


Bioorg Med Chem Lett 16: 5610-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.020
BindingDB Entry DOI: 10.7270/Q28G8MH4
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50194316
PNG
((5R,2'S)-5-(1-methyl-2-pyrrolidinyl)oxazolidinone ...)
Show SMILES CN1CCC[C@H]1[C@H]1CNC(=O)O1
Show InChI InChI=1S/C8H14N2O2/c1-10-4-2-3-6(10)7-5-9-8(11)12-7/h6-7H,2-5H2,1H3,(H,9,11)/t6-,7+/m0/s1
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1.17E+5n/an/an/an/an/an/an/an/a



Universit£ di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]alpha-Bungarotoxin from alpha-7 nAChR in rat brain cortex membranes


Bioorg Med Chem Lett 16: 5610-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.020
BindingDB Entry DOI: 10.7270/Q28G8MH4
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50194313
PNG
((5S,2'R)-5-(1-methyl-2-pyrrolidinyl)oxazolidinone ...)
Show SMILES CN1CCC[C@@H]1[C@@H]1CNC(=O)O1
Show InChI InChI=1S/C8H14N2O2/c1-10-4-2-3-6(10)7-5-9-8(11)12-7/h6-7H,2-5H2,1H3,(H,9,11)/t6-,7+/m1/s1
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PubMed
3.38E+5n/an/an/an/an/an/an/an/a



Universit£ di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]alpha-Bungarotoxin from alpha-7 nAChR in rat brain cortex membranes


Bioorg Med Chem Lett 16: 5610-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.020
BindingDB Entry DOI: 10.7270/Q28G8MH4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%