Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50019719
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207078(4-(3,5-Difluorophenyl)-N-(6-methylpyrindin-2-yl)pi...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207080(CHEMBL248141 | N-(6-methylpyridin-2-yl)-5-(pyridin...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207082(CHEMBL245877 | N-(6-methylpyridin-2-yl)-4-(naphtha...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207079(4-(3-cyanophenyl)-N-(6-methylpyridin-2-yl)picolina...)
Affinity DataKi:  320nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207081(CHEMBL248128 | N-(6-methylpyridin-2-yl)isoquinolin...)
Affinity DataKi:  440nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207088(4-(3-fluorophenyl)-N-(6-methylpyridin-2-yl)picolin...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207086(5-(2-methoxyphenyl)-N-(6-methylpyridin-2-yl)picoli...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207083(CHEMBL247330 | N-(6-methylpyridin-2-yl)-4-(pyrimid...)
Affinity DataKi:  2.48E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207087(CHEMBL396078 | N-(6-methylpyridin-2-yl)-5-phenylpi...)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207085(1-methyl-N-(6-methylpyridin-2-yl)-1H-imidazole-2-c...)
Affinity DataKi:  3.07E+3nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207084(1-methyl-N-(6-methylpyridin-2-yl)-1H-pyrrole-2-car...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MPEP from mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207078(4-(3,5-Difluorophenyl)-N-(6-methylpyrindin-2-yl)pi...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at mGluR5 expressed in CHO cells assessed as phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50186330(3-cyano-N-(6-methylpyridin-2-yl)benzamide | CHEMBL...)
Affinity DataIC50:  5.33E+3nMAssay Description:Antagonist activity at mGluR5 expressed in CHO cells assessed as phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207079(4-(3-cyanophenyl)-N-(6-methylpyridin-2-yl)picolina...)
Affinity DataIC50:  7.30E+3nMAssay Description:Antagonist activity at mGluR5 expressed in CHO cells assessed as phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50207080(CHEMBL248141 | N-(6-methylpyridin-2-yl)-5-(pyridin...)
Affinity DataIC50:  1.24E+4nMAssay Description:Antagonist activity at mGluR5 expressed in CHO cells assessed as phosphoinositide hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed