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Found 42 Enz. Inhib. hit(s) with all data for entry = 50019993
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209545(2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209538(1-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209547(2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209526(3-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209522((S)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209543((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-quinoli...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209539(2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209525((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-metho...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209536(4-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209519(4-[3-cyano-2-(2'-ethoxy-3-fluoro-biphenyl-4-yl)-6-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209513(CHEMBL245788 | {[3-cyano-2-(2'-ethoxy-biphenyl-4-y...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209512((S)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209544(2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209531((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209551(2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209533((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-7-methy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209542(CHEMBL245984 | {[3-cyano-2-(2'-ethoxy-biphenyl-4-y...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209523(CHEMBL247973 | [3-cyano-2-(2'-ethoxy-biphenyl-4-yl...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209532(2-{[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-q...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209535(1-[3-Cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluoro-qu...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209541((R)-2-[6-chloro-3-cyano-2-(2'-ethoxy-biphenyl-4-yl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209527(4-[3-cyano-2-(2'-ethoxy-2-fluoro-biphenyl-4-yl)-6-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209548((R)-2-[7-chloro-3-cyano-2-(2'-ethoxy-biphenyl-4-yl...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209529((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209521(3-[2-(2'-trifluoromethyl-biphenyl-4-yl)-quinolin-4...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209516(4-[3-cyano-2-(2'-ethoxy-2-methyl-biphenyl-4-yl)-6-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209550(3-[2-(2'-ethoxy-biphenyl-4-yl)-quinolin-4-ylamino]...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209518(3-[2-(2'-ethyl-biphenyl-4-yl)-quinolin-4-ylamino]-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209528(3-[2-(2'-morpholin-4-ylmethyl-biphenyl-4-yl)-quino...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209512((S)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  66nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209546((R)-2-[3-cyano-2-(2'-ethoxy-3-fluoro-biphenyl-4-yl...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209515((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6,7-dif...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209530(4-[3-cyano-2-(2'-ethoxy-3-methyl-biphenyl-4-yl)-6-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209537(CHEMBL391364 | {[3-cyano-2-(2'-ethoxy-biphenyl-4-y...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209520(3-[2-(4'-methyl-biphenyl-4-yl)-quinolin-4-ylamino]...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209540((R)-2-[3-cyano-2-(2'-ethoxy-2-fluoro-biphenyl-4-yl...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209514(3-methyl-2-(4-propylphenyl)quinoline-4-carboxylic ...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209549((R)-2-[3-cyano-2-(2'-ethoxy-2-methyl-biphenyl-4-yl...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209534((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-8-methy...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209531((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209517((R)-2-[3-cyano-2-(2'-ethoxy-3-methyl-biphenyl-4-yl...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Bayer Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50209524((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-5,6-dif...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of human recombinant PDE10A transfected in insect Sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed