Compile Data Set for Download or QSAR
maximum 50k data
Found 39 Enz. Inhib. hit(s) with all data for entry = 50021394
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224184(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224179(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224185(1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity at mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224183(1-{2-[(1S)-(methylaminopropionyl)amino-2-methylpro...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224177(1-{2-[(1S)-(aminopropionyl)amino-2-methylpropyl]-4...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224178((R)-3-(4-chloro-2-fluorophenyl)-2-methyl-1-(4-(4-m...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224180((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224186((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataKi:  35nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataKi:  69nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224185(1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-...)
Affinity DataKi:  180nMAssay Description:Displacement of [125I]NDP-MSH from human MC5RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224185(1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-...)
Affinity DataKi:  230nMAssay Description:Displacement of [125I]NDP-MSH from human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224177(1-{2-[(1S)-(aminopropionyl)amino-2-methylpropyl]-4...)
Affinity DataKi:  270nMAssay Description:Displacement of [125I]NDP-MSH from human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224177(1-{2-[(1S)-(aminopropionyl)amino-2-methylpropyl]-4...)
Affinity DataKi:  320nMAssay Description:Displacement of [125I]NDP-MSH from human MC5RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  340nMAssay Description:Displacement of [125I]NDP-MSH from human MC5RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224183(1-{2-[(1S)-(methylaminopropionyl)amino-2-methylpro...)
Affinity DataKi:  360nMAssay Description:Displacement of [125I]NDP-MSH from human MC5RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  420nMAssay Description:Displacement of [125I]NDP-MSH from human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224183(1-{2-[(1S)-(methylaminopropionyl)amino-2-methylpro...)
Affinity DataKi:  710nMAssay Description:Displacement of [125I]NDP-MSH from human MC3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224183(1-{2-[(1S)-(methylaminopropionyl)amino-2-methylpro...)
Affinity DataIC50:  87nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224184(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50:  92nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224179(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50:  190nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224177(1-{2-[(1S)-(aminopropionyl)amino-2-methylpropyl]-4...)
Affinity DataIC50:  280nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224185(1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-...)
Affinity DataIC50:  410nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224178((R)-3-(4-chloro-2-fluorophenyl)-2-methyl-1-(4-(4-m...)
Affinity DataIC50:  660nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataIC50:  2.40E+3nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224183(1-{2-[(1S)-(methylaminopropionyl)amino-2-methylpro...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224179(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224184(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224185(1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224182((R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylp...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224178((R)-3-(4-chloro-2-fluorophenyl)-2-methyl-1-(4-(4-m...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224177(1-{2-[(1S)-(aminopropionyl)amino-2-methylpropyl]-4...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224181(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed