Compile Data Set for Download or QSAR
maximum 50k data
Found 12 Enz. Inhib. hit(s) with all data for entry = 2911
LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/mole IC50:  59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi:  240nM ΔG°:  -37.4kJ/mole IC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi:  400nM ΔG°:  -36.2kJ/mole IC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi:  480nM ΔG°:  -35.7kJ/mole IC50:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.7kJ/mole IC50:  1.00E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/mole IC50:  8.40E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: >1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: >1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed