Compile Data Set for Download or QSAR
maximum 50k data
Found 27 Enz. Inhib. hit(s) with all data for entry = 2517
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21506(Dihydropyrrolopyrazole, 15a | dimethyl[2-({4-[2-(p...)
Affinity DataIC50:  24nM EC50:  29nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21505(7-(2-chloroethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6H-py...)
Affinity DataIC50:  33nM EC50:  66nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21510(Dihydropyrrolopyrazole, 16a | dimethyl[5-({4-[2-(p...)
Affinity DataIC50:  47nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21511(1-(4-methylpiperazin-1-yl)-2-({4-[2-(pyridin-2-yl)...)
Affinity DataIC50:  49nM EC50:  260nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  59nM EC50:  40nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataIC50:  69nM EC50:  180nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21513(7-[3-(1-methylpyrrolidin-2-yl)propoxy]-4-[2-(pyrid...)
Affinity DataIC50:  72nM EC50:  17nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21504(7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[2-(pyridi...)
Affinity DataIC50:  74nM EC50:  44nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21507(Dihydropyrrolopyrazole, 15b | ethyl(methyl)[2-({4-...)
Affinity DataIC50:  85nM EC50:  61nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21496(6-bromo-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrro...)
Affinity DataIC50:  89nM EC50:  55nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21508(7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-[2-(pyridin...)
Affinity DataIC50:  100nM EC50:  38nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21512(7-(oxolan-2-ylmethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6...)
Affinity DataIC50:  130nM EC50:  80nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21497(4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a...)
Affinity DataIC50:  141nM EC50:  201nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21503(4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...)
Affinity DataIC50:  160nM EC50:  200nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21499(Dihydropyrrolopyrazole, 9 | N-[2-(dimethylamino)et...)
Affinity DataIC50:  193nM EC50:  468nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21498(Dihydropyrrolopyrazole, 8 | methyl 4-[2-(6-methylp...)
Affinity DataIC50:  526nM EC50:  403nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21518(Dihydropyrrolopyrazole, 23 | dimethyl({[4-({4-[2-(...)
Affinity DataIC50:  750nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21495(8-fluoro-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrr...)
Affinity DataIC50:  928nM EC50:  951nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21515(4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyr...)
Affinity DataIC50:  1.10E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21517(Dihydropyrrolopyrazole, 22 | N,N-dimethyl-4-({4-[2...)
Affinity DataIC50:  1.10E+3nM EC50:  1.50E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21514(4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyr...)
Affinity DataIC50:  1.20E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21494(6,8-dimethoxy-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H...)
Affinity DataIC50:  3.81E+3nM EC50:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21516(4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyr...)
Affinity DataIC50:  4.80E+3nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21493(2-chloro-4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-...)
Affinity DataIC50:  1.98E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21501(2-(ethylsulfanyl)-4-[2-(pyridin-2-yl)-4H,5H,6H-pyr...)
Affinity DataIC50: >2.00E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21502(4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...)
Affinity DataIC50: >2.00E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21500(2-methoxy-4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2...)
Affinity DataIC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed