Compile Data Set for Download or QSAR
maximum 50k data
Found 27 Enz. Inhib. hit(s) with all data for entry = 50022657
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237869((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237870(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237874((+/-)-2-(1-(2-(2-methylpyrrolidin-1-yl)ethyl)-3-(2...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237872(2-(3-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)-1-(2-(...)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237870(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237869((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Affinity DataKi:  0.680nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237874((+/-)-2-(1-(2-(2-methylpyrrolidin-1-yl)ethyl)-3-(2...)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237872(2-(3-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)-1-(2-(...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237875(2-(1,3-bis(2-((R)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  1.26nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237875(2-(1,3-bis(2-((R)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237878(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237878(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237871(2-(1-(2-(piperidin-1-yl)ethyl)-3-(3-(piperidin-1-y...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237871(2-(1-(2-(piperidin-1-yl)ethyl)-3-(3-(piperidin-1-y...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237873(2-(1-(4-(piperidin-1-yl)butyl)-3-(2-(piperidin-1-y...)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237873(2-(1-(4-(piperidin-1-yl)butyl)-3-(2-(piperidin-1-y...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237879(2-(1,3-bis(2-(piperidin-1-yl)ethyl)imidazolidin-2-...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237876(2-(1-(naphthalen-1-ylmethyl)-3-(3-(piperidin-1-yl)...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237879(2-(1,3-bis(2-(piperidin-1-yl)ethyl)imidazolidin-2-...)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237877(2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)eth...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237877(2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)eth...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237876(2-(1-(naphthalen-1-ylmethyl)-3-(3-(piperidin-1-yl)...)
Affinity DataKi:  690nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237870(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at histamine H3 receptor in rat forebrain assessed as inhibition of [3H]histamine release from synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237869((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Affinity DataIC50:  4.90nMAssay Description:Antagonist activity at histamine H3 receptor in rat forebrain assessed as inhibition of [3H]histamine release from synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50237878(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at histamine H3 receptor in rat forebrain assessed as inhibition of [3H]histamine release from synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed