Compile Data Set for Download or QSAR
maximum 50k data
Found 31 Enz. Inhib. hit(s) with all data for entry = 50026044
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  0.650nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  0.660nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239749(2-(4-(6-chloro-2-(3-methylpentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239745(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [3H]U-69593 from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260630(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239745(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  9.70nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239754(2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]imida...)
Affinity DataIC50:  17nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260632(2-((1S,4S)-5-(6-chloro-2-(pentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  18nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239754(2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]imida...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260630(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]diprenorphin from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260632(2-((1S,4S)-5-(6-chloro-2-(pentan-3-ylthio)-3H-benz...)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260631(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  59nMAssay Description:Antagonist activity at human ORL1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataIC50:  67nMAssay Description:Displacement of [3H]diprenorphin from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260631(2-(4-(6-chloro-2-(pentan-3-ylthio)-3H-benzo[d]imid...)
Affinity DataIC50:  73nMAssay Description:Displacement of [125I]Tyr14-NC/OFQ from human ORL1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  97nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]U-69593 from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239754(2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]imida...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]U-69593 from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  180nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataIC50:  238nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239754(2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]imida...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  1.20E+3nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM29995(CHEMBL494350 | benzimidazole-based antagonist, 1)
Affinity DataIC50:  1.90E+3nMAssay Description:Displacement of [3H]diprenorphin from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50239754(2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]imida...)
Affinity DataIC50:  4.40E+3nMAssay Description:Displacement of [3H]diprenorphin from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50260633((S)-2-(4-(2-(tert-butylthio)-6-chloro-3H-benzo[d]i...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed