Compile Data Set for Download or QSAR
maximum 50k data
Found 50 Enz. Inhib. hit(s) with all data for entry = 50026374
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243125(CHEMBL487864 | N3-(6-acetamidopyridin-3-yl)-4-meth...)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26365(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243076(CHEMBL470483 | N3-(6-aminopyridin-3-yl)-4-methyl-N...)
Affinity DataIC50:  7nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243181(CHEMBL520718 | N3-(6-aminopyridin-3-yl)-N1-(3-cycl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Affinity DataIC50:  14nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243075(4-methyl-N3-(pyridin-3-yl)-N1-(3-(trifluoromethyl)...)
Affinity DataIC50:  18nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243076(CHEMBL470483 | N3-(6-aminopyridin-3-yl)-4-methyl-N...)
Affinity DataIC50:  24nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243180(CHEMBL488834 | N3-(6-aminopyridin-3-yl)-N1-(2-cycl...)
Affinity DataIC50:  35nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50:  37nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243125(CHEMBL487864 | N3-(6-acetamidopyridin-3-yl)-4-meth...)
Affinity DataIC50:  45nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  52nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243181(CHEMBL520718 | N3-(6-aminopyridin-3-yl)-N1-(3-cycl...)
Affinity DataIC50:  57.8nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243124(CHEMBL487863 | N3-(2-acetamidopyrimidin-5-yl)-4-me...)
Affinity DataIC50:  58nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243182(CHEMBL487431 | N'-(6-aminopyridin-3-yl)-N-(2-cyclo...)
Affinity DataIC50:  77nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26365(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50:  87nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243074(CHEMBL469882 | N-(2-methyl-5-((3-(trifluoromethyl)...)
Affinity DataIC50:  108nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243125(CHEMBL487864 | N3-(6-acetamidopyridin-3-yl)-4-meth...)
Affinity DataIC50:  114nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243126(CHEMBL487865 | N3-(6-aminopyridin-3-yl)-4-methyl-N...)
Affinity DataIC50:  120nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243180(CHEMBL488834 | N3-(6-aminopyridin-3-yl)-N1-(2-cycl...)
Affinity DataIC50:  181nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Affinity DataIC50:  200nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26365(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50:  205nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243075(4-methyl-N3-(pyridin-3-yl)-N1-(3-(trifluoromethyl)...)
Affinity DataIC50:  219nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243075(4-methyl-N3-(pyridin-3-yl)-N1-(3-(trifluoromethyl)...)
Affinity DataIC50:  294nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243074(CHEMBL469882 | N-(2-methyl-5-((3-(trifluoromethyl)...)
Affinity DataIC50:  455nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243076(CHEMBL470483 | N3-(6-aminopyridin-3-yl)-4-methyl-N...)
Affinity DataIC50:  470nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50:  546nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243124(CHEMBL487863 | N3-(2-acetamidopyrimidin-5-yl)-4-me...)
Affinity DataIC50:  748nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243182(CHEMBL487431 | N'-(6-aminopyridin-3-yl)-N-(2-cyclo...)
Affinity DataIC50:  998nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243179(CHEMBL488833 | N3-(6-aminopyridin-3-yl)-N1-(cycloh...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243124(CHEMBL487863 | N3-(2-acetamidopyrimidin-5-yl)-4-me...)
Affinity DataIC50:  1.73E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243074(CHEMBL469882 | N-(2-methyl-5-((3-(trifluoromethyl)...)
Affinity DataIC50:  2.76E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50242924(4-methyl-N3-(pyrimidin-5-yl)-N1-(3-(trifluoromethy...)
Affinity DataIC50:  3.53E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243183(CHEMBL505394 | N3-(6-aminopyridin-3-yl)-4-methyl-N...)
Affinity DataIC50:  3.64E+3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243074(CHEMBL469882 | N-(2-methyl-5-((3-(trifluoromethyl)...)
Affinity DataIC50:  3.76E+3nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243127(CHEMBL443902 | N3-(6-aminopyridin-3-yl)-N1-cyclohe...)
Affinity DataIC50:  4.47E+3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243074(CHEMBL469882 | N-(2-methyl-5-((3-(trifluoromethyl)...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243181(CHEMBL520718 | N3-(6-aminopyridin-3-yl)-N1-(3-cycl...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243126(CHEMBL487865 | N3-(6-aminopyridin-3-yl)-4-methyl-N...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Affinity DataIC50: >8.33E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243180(CHEMBL488834 | N3-(6-aminopyridin-3-yl)-N1-(2-cycl...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50243182(CHEMBL487431 | N'-(6-aminopyridin-3-yl)-N-(2-cyclo...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair