Compile Data Set for Download or QSAR
maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for entry = 50026429
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50205278(2-(4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-...)
Affinity DataKi:  0.570nMAssay Description:Inhibition of prostaglandin DP receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251428(2-(4-(4-chlorobenzyl)-5-acetyl-7-fluoro-1,2,3,4-te...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of prostaglandin DP receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184212((R)-2-(4-(4-chlorobenzyl)-5-acetyl-7-(methylsulfon...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of prostaglandin DP receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251417(4-[(R)-2-(4-Fluoro-benzyl)-1,3-dioxo-decahydro-pyr...)
Affinity DataKi:  57nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251440(4-((R)-2-Benzyl-1,3-dioxo-decahydro-pyrrolo[3,4-a]...)
Affinity DataKi:  310nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251416(4-[(R)-2-(3-Fluoro-benzyl)-1,3-dioxo-decahydro-pyr...)
Affinity DataKi:  360nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251415(4-[(R)-2-(2-Fluoro-benzyl)-1,3-dioxo-decahydro-pyr...)
Affinity DataKi:  500nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251429(4'-Piperazin-1-yl-biphenyl-4-carboxylic acid [(S)-...)
Affinity DataIC50:  0.0150nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067933(5-(((2S,3S)-2-(3,5-bis(trifluoromethyl)benzyloxy)-...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067937(5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phen...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049469(5-(((2S,3S)-2-(3,5-bis(trifluoromethyl)benzyloxy)-...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220136(3-[2-{1-[3,5-di(trifluoromethyl)phenyl]ethoxy}-3-(...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19489((2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Affinity DataIC50:  0.290nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240981(4'-piperazin-1-yl-biphenyl-4-carboxylic acid [1-(c...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200833(CHEMBL373626 | N-((2S,3S)-4-(4-chlorophenyl)-3-phe...)
Affinity DataIC50:  0.540nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200844(CHEMBL219480 | N-((2S,3S)-4-(4-chlorophenyl)-3-phe...)
Affinity DataIC50:  1.47nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200831(CHEMBL374791 | N-((2S,3S)-4-(4-chlorophenyl)-3-phe...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200838(CHEMBL217862 | N-((2S,3S)-4-(4-chlorophenyl)-3-phe...)
Affinity DataIC50:  2.03nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50251439(1-[(S)-2,2,2-Trifluoro-1-(4'-piperazin-1-yl-biphen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  18nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11160((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Affinity DataIC50:  27nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210652((R)-3-amino-1-(3-ethyl-5,6-dihydro-[1,2,4]triazolo...)
Affinity DataIC50:  37nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11161((1R)-3-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7...)
Affinity DataIC50:  68nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11163((1R)-1-(2,5-difluorobenzyl)-3-oxo-3-[3-(2,2,2-trif...)
Affinity DataIC50:  71nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210658((R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,...)
Affinity DataIC50:  87nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM11159((1R)-1-(3,4-difluorobenzyl)-3-oxo-3-[3-(trifluorom...)
Affinity DataIC50:  128nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210653((R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,...)
Affinity DataIC50:  151nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50210655((R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,...)
Affinity DataIC50:  805nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed