Compile Data Set for Download or QSAR
maximum 50k data
Found 33 Enz. Inhib. hit(s) with all data for entry = 50026850
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245422(6-(6,7-dimethoxyquinolin-4-yloxy)-N-(2-methoxyphen...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245169(1-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245770(1-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245771(1-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-i...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245419(CHEMBL450163 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245421(6-(6,7-dimethoxyquinolin-4-yloxy)-N-phenylnaphthal...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245418(CHEMBL518203 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245378(4-chloro-N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-me...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245375(CHEMBL462348 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245376(CHEMBL462349 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245377(3-chloro-N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-me...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245336(4-chloro-N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-me...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245335(2-chloro-N-(6-(6,7-dimethoxyquinolin-4-yloxy)-1-me...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245769(1-(2-chloro-4-(trifluoromethyl)phenyl)-3-(6-(6,7-d...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  45nMAssay Description:Inhibition of aurora 1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245333(CHEMBL462381 | N-benzyl-6-(6,7-dimethoxyquinolin-4...)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245294(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-N-(4-(t...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  121nMAssay Description:Inhibition of Tie 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245293(6-(6,7-dimethoxyquinolin-4-yloxy)-N-(4-methoxyphen...)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245292(6-(6,7-dimethoxyquinolin-4-yloxy)-N-(3-methoxyphen...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245291(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-N-pheny...)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245334(CHEMBL462382 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  344nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245171(6-(6,7-dimethoxyquinolin-4-yloxy)-N-ethyl-1-methyl...)
Affinity DataIC50:  370nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  764nMAssay Description:Inhibition of aurora 2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245222(CHEMBL453354 | N-butyl-6-(6,7-dimethoxyquinolin-4-...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245172(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-N-propy...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245170(6-(6,7-dimethoxyquinolin-4-yloxy)-1-methyl-1H-inda...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant KDR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  3.25E+3nMAssay Description:Inhibition of PI3KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  3.32E+3nMAssay Description:Inhibition of cMETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  2.50E+7nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50245420(CHEMBL462168 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)
Affinity DataIC50:  2.50E+7nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed