Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 50038660
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50181089(6-(azepan-1-yl)-N,2-dicyclopropyl-5-methylpyrimidi...)
Affinity DataKi:  3.20nMAssay Description:Antagonist activity at muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50245245(4-{2-(3,4-Bis-difluoromethoxy-phenyl)-2-[4-(1-meth...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST-tagged PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50085135(4-(8-(3-nitrophenyl)-1,7-naphthyridin-6-yl)benzoic...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50119355(2-{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(3-meth...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST-tagged PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of GST-tagged PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PDE4B2 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PDE4B3 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PDE4D2 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PDE4D4 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PDE4B1 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human PDE4D1 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404((Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human PDE4D4 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404((Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3...)
Affinity DataIC50:  65nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human PDE4B1 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human PDE4D5 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human PDE4B3 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human PDE4D3 in cytosolic fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404((Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3...)
Affinity DataIC50:  166nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2C9(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50174022((E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human PDE4B2 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50240404((Ibudilast)1-(2-Isopropyl-pyrazolo[1,5-a]pyridin-3...)
Affinity DataIC50:  239nMAssay Description:Inhibition of human PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50236083(5-[1-(3-Cyclopentyloxy-4-methoxy-phenyl)-meth-(Z)-...)
Affinity DataIC50:  310nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human PDE4D3 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  590nMAssay Description:Inhibition of human PDE4D5 in particular fraction of lungMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50236078(5-(3-(cyclopentyloxy)-4-methoxybenzylidene)-2-thio...)
Affinity DataIC50:  890nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Matrix Laboratories

Curated by ChEMBL
LigandPNGBDBM50236078(5-(3-(cyclopentyloxy)-4-methoxybenzylidene)-2-thio...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed