Compile Data Set for Download or QSAR
maximum 50k data
Found 26 Enz. Inhib. hit(s) with all data for entry = 50026983
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264392(CHEMBL490823 | N-(6-acetamidopyridin-3-yl)-6-chlor...)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264437(CHEMBL488984 | N-(2-aminopyrimidin-5-yl)-6-chloro-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264391(CHEMBL523816 | N-(6-aminopyridin-3-yl)-6-chloro-3-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264439(6-chloro-N-(pyridin-3-yl)-3-(3-(trifluoromethyl)ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264438(CHEMBL488985 | N-(2-acetamidopyrimidin-5-yl)-6-chl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264363(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethoxy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264361(3-(3-tert-butylphenylamino)-6-chloro-N-(pyrimidin-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264291(6-chloro-3-(4-ethylphenylamino)-N-(pyrimidin-5-yl)...)
Affinity DataIC50:  7nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264292(6-chloro-3-(4-propylphenylamino)-N-(pyrimidin-5-yl...)
Affinity DataIC50:  7nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264322(3-(4-tert-butylphenylamino)-6-chloro-N-(pyrimidin-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264360(6-chloro-N-(pyrimidin-5-yl)-3-(4-(trifluoromethoxy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264323(6-chloro-N-(pyrimidin-5-yl)-3-(4-(trifluoromethyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264390(6-chloro-3-(4-fluoro-3-(trifluoromethyl)phenylamin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Affinity DataIC50:  14nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264440(6-chloro-N-(2-chloropyrimidin-5-yl)-3-(3-(trifluor...)
Affinity DataIC50:  20nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264320(3-(4-butylphenylamino)-6-chloro-N-(pyrimidin-5-yl)...)
Affinity DataIC50:  28nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  58nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264362(6-chloro-3-(3-cyanophenylamino)-N-(pyrimidin-5-yl)...)
Affinity DataIC50:  59nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  71nMAssay Description:Inhibition of cFMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  75nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  117nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264321(6-chloro-3-(4-pentylphenylamino)-N-(pyrimidin-5-yl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50:  353nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50264389(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of Tie2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed