Compile Data Set for Download or QSAR
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Found 6 Enz. Inhib. hit(s) with all data for entry = 50027247
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  9nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by whole cell patch clamp a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  40nMpH: 5.3Assay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  49nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx by whole cell patch clamp ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Cavia porcellus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  63nMpH: 5.3Assay Description:Antagonist activity at guinea pig TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263384(6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...)
Affinity DataIC50:  100nMpH: 5.3Assay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263425(6-(4-fluorophenyl)-2-methyl-N-(quinolin-7-yl)nicot...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed