Affinity Data by PubMed id=19233643

PubMed code 19233643

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50137863 (4-(3-Benzylamino-phenyl)-2,4-dioxo-butyric acid \| ...) Show SMILES OC(=O)C(=O)CC(=O)c1cccc(NCc2ccccc2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258183 (4-(3-(4-chlorobenzylamino)phenyl)-2-hydroxy-4-oxob...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258134 (4-(3-(4-chlorobenzyloxy)phenyl)-2-hydroxy-4-oxobut...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258134 (4-(3-(4-chlorobenzyloxy)phenyl)-2-hydroxy-4-oxobut...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.44E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258136 (4-(2-(4-chlorobenzyloxy)phenyl)-2-hydroxy-4-oxobut...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1OCc1ccc(Cl)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.87E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258085 (4-(4-(benzyloxy)phenyl)-2-hydroxy-4-oxobut-2-enoic...) Show SMILES OC(=O)C(=O)CC(=O)c1ccc(OCc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.99E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258085 (4-(4-(benzyloxy)phenyl)-2-hydroxy-4-oxobut-2-enoic...) Show SMILES OC(=O)C(=O)CC(=O)c1ccc(OCc2ccccc2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50137863 (4-(3-Benzylamino-phenyl)-2,4-dioxo-butyric acid \| ...) Show SMILES OC(=O)C(=O)CC(=O)c1cccc(NCc2ccccc2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258183 (4-(3-(4-chlorobenzylamino)phenyl)-2-hydroxy-4-oxob...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50115572 ((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...) Show SMILES OC(=O)C(=O)CC(=O)c1cccc(OCc2ccccc2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50137878 (4-(2-Benzyloxy-phenyl)-2,4-dioxo-butyric acid \| 4-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1OCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258136 (4-(2-(4-chlorobenzyloxy)phenyl)-2-hydroxy-4-oxobut...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1OCc1ccc(Cl)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258132 (4-(4-(4-chlorobenzyloxy)phenyl)-2-hydroxy-4-oxobut...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50258132 (4-(4-(4-chlorobenzyloxy)phenyl)-2-hydroxy-4-oxobut...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50115572 ((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...) Show SMILES OC(=O)C(=O)CC(=O)c1cccc(OCc2ccccc2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair
3C-like proteinase (3CL-PRO) (Human SARS coronavirus (SARS-CoV) (Severe acute re...)	BDBM50137878 (4-(2-Benzyloxy-phenyl)-2,4-dioxo-butyric acid \| 4-...) Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1OCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Konkuk University Curated by ChEMBL					Assay Description Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay				Bioorg Med Chem Lett 19: 1636-8 (2009) Article DOI: 10.1016/j.bmcl.2009.02.010 BindingDB Entry DOI: 10.7270/Q2CR5T7K
Konkuk University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%