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Found 28 Enz. Inhib. hit(s) with all data for entry = 50030412
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295819(12,13-(2,3-cis-dihydroxy-butan-1,4-yl)-12,13-dihyd...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295821(12,13-(2-hydroxy-butan-1,4-yl)-12,13-dihydro-5,7-d...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50:  7nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295820(12,13-(2-hydroxy-pentan-1,5-yl)-12,13-dihydro-5,7-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295817(12,13-[2-carboxy-cis-2,3-dihydroxy-1,4-butyl]-6,7,...)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295818(12,13-(2,3-cis-dihydroxy-pentan-1,5-yl)-12,13-dihy...)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295812(12,13-(3,4-Cis-dihyroxy-1,6-hexyl)-6,7,12,13-tetra...)
Affinity DataIC50:  12nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295816((16S,17R)-16-{[3-(dimethylamino)pyrrolidin-1-yl]ca...)
Affinity DataIC50:  15nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295813(12,13-(1,6-hex-cis-3-enyl)-6,7,12,13-tetrahydro-5-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295814(12,13-(1,4-but-cis-2-enyl)-6,7,12,13-tetrahydro-5-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM2581(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Affinity DataIC50:  61nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295815(12,13-diallyl-6,7,12,13-tetrahydro-5-oxo-5H-indolo...)
Affinity DataIC50: >200nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50:  300nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50:  300nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50:  540nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 5A(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50:  689nMAssay Description:Inhibition of STAT5 phosphorylation in IL2-stimulated healthy human T cells by western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SYK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295811(12,13-[2-carboxymethyl-cis-2,3-dihydroxy)-1,4-buty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MK2-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295809(12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of LCK-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295810(12,13-[2-carbomethoxy-1,4-but-cis-2-enyl]-6,7,12,1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Zap70-mediated inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed