Compile Data Set for Download or QSAR
maximum 50k data
Found 39 Enz. Inhib. hit(s) with all data for entry = 50033474
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346079((3-amino-4,6-dimethylfuro[2,3-b]pyridine-2-yl)(4-f...)
Affinity DataKi:  410nMAssay Description:Displacement of [3H]3-methoxy-5-(2-pyridinylethynyl) pyridine from mGluR5 allosteric siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataKi:  440nMAssay Description:Displacement of [3H]3-methoxy-5-(2-pyridinylethynyl) pyridine from mGluR5 allosteric siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataKi:  840nMAssay Description:Displacement of [3H]3-methoxy-5-(2-pyridinylethynyl) pyridine from mGluR5 allosteric siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50:  540nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50:  820nMAssay Description:Non-competitive antagonist activity at mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346083((3-amino-6-methyl-4-(trifluoromethyl)furo[2,3-b]py...)
Affinity DataIC50:  840nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339074(Adamantan-1-yl-(4-thiazol-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50:  990nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346075(2-azaspiro[5.5]undecan-2-yl(thiophen-2-yl)methanon...)
Affinity DataIC50:  1.18E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346074(CHEMBL1783976 | furan-2-yl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50:  1.54E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346078(2-[4-(Adamantane-1-carbonyl)-piperazin-1-yl]-benzo...)
Affinity DataIC50:  2.35E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346076(CHEMBL1783979 | quinoxalin-2-yl(2-azaspiro[5.5]und...)
Affinity DataIC50:  5.02E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346077(2-(phenylthio)-1-(2-azaspiro[5.5]undecan-2-yl)etha...)
Affinity DataIC50:  5.24E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346084((3-amino-4,6-dimethylfuro[2,3-b]pyridin-2-yl)(2,4-...)
Affinity DataIC50:  9.30E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346069(CHEMBL1783984 | cyclopentyl(2-azaspiro[5.5]undecan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346067(1-(2-azaspiro[5.5]undecan-2-yl)-2-(thiophen-2-yl)e...)
Affinity DataIC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346086(Adamantan-1-yl-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346071(Adamantan-1-yl-(4-pyridin-3-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346085((3-amino-4,6-dimethylfuro[2,3-b]pyridin-2-yl)(phen...)
Affinity DataIC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346070(CHEMBL1783986 | cyclopropyl(2-azaspiro[5.5]undecan...)
Affinity DataIC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346066(2-azaspiro[5.5]undecan-2-yl(p-tolyl)methanone | CH...)
Affinity DataIC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346072(Adamantan-1-yl-(4-pyridin-4-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346068(CHEMBL1783983 | cyclohexyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346065(CHEMBL1783978 | pyridin-3-yl(2-azaspiro[5.5]undeca...)
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346087(Adamantan-1-yl-[4-(2-chloro-phenyl)-piperazin-1-yl...)
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(CHEMBL1783985 | cyclobutyl(2-azaspiro[5.5]undecan-...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346079((3-amino-4,6-dimethylfuro[2,3-b]pyridine-2-yl)(4-f...)
Affinity DataIC50:  5.40E+4nMAssay Description:Non-competitive antagonist activity at mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346080((3-amino-5-chloro-4-(methoxymethyl)-6-methylfuro[2...)
Affinity DataEC50:  6.50E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346081((3-amino-5-bromofuro[2,3-b]pyridin-2-yl)(4-fluorop...)
Affinity DataEC50:  7.60E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346082((3-amino-6-hydroxy-4-methylfuro[2,3-b]pyridin-2-yl...)
Affinity DataEC50:  6.10E+3nMAssay Description:Positive allosteric modulation of mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed