Compile Data Set for Download or QSAR
maximum 50k data
Found 90 Enz. Inhib. hit(s) with all data for entry = 50028783
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268906((2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268906((2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269059((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268906((2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  28nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)
Affinity DataIC50:  52nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269000((1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)e...)
Affinity DataIC50:  58nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269000((1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)e...)
Affinity DataIC50:  60nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268999((1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269059((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)
Affinity DataIC50:  67nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268952((2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(piperid...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268952((2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(piperid...)
Affinity DataIC50:  81nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269002((1S,2S,5RS)-N-hydroxy-5-(2-morpholino-2-oxoethyl)-...)
Affinity DataIC50:  83nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268951((2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(pyrroli...)
Affinity DataIC50:  92nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268999((1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  99nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268954((5S,6S)-N-hydroxy-6-(4-phenylpiperazine-1-carbonyl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268952((2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(piperid...)
Affinity DataIC50:  102nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268954((5S,6S)-N-hydroxy-6-(4-phenylpiperazine-1-carbonyl...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269056((1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidi...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268904(CHEMBL445717 | benzyl 5-(2-((3RS,5S,6S)-5-(hydroxy...)
Affinity DataIC50:  137nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269056((1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidi...)
Affinity DataIC50:  156nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268905((2S,3S,5RS)-5-(2-(5-aminopentylamino)-2-oxoethyl)-...)
Affinity DataIC50:  161nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268905((2S,3S,5RS)-5-(2-(5-aminopentylamino)-2-oxoethyl)-...)
Affinity DataIC50:  162nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269058((1S,2S,5R)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  165nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268951((2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(pyrroli...)
Affinity DataIC50:  167nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269058((1S,2S,5R)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  170nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268953((1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268951((2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(pyrroli...)
Affinity DataIC50:  194nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268954((5S,6S)-N-hydroxy-6-(4-phenylpiperazine-1-carbonyl...)
Affinity DataIC50:  196nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269002((1S,2S,5RS)-N-hydroxy-5-(2-morpholino-2-oxoethyl)-...)
Affinity DataIC50:  208nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269056((1S,2S,5RS)-N-hydroxy-5-(2-((R)-3-hydroxypyrrolidi...)
Affinity DataIC50:  226nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)
Affinity DataIC50:  230nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269002((1S,2S,5RS)-N-hydroxy-5-(2-morpholino-2-oxoethyl)-...)
Affinity DataIC50:  236nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268999((1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  271nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50268904(CHEMBL445717 | benzyl 5-(2-((3RS,5S,6S)-5-(hydroxy...)
Affinity DataIC50:  302nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269000((1S,2S,5RS)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)e...)
Affinity DataIC50:  321nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50:  323nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227986((6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-...)
Affinity DataIC50:  359nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268953((1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl...)
Affinity DataIC50:  470nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268954((5S,6S)-N-hydroxy-6-(4-phenylpiperazine-1-carbonyl...)
Affinity DataIC50:  577nMAssay Description:Inhibition of human MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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