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PubMed code 19555163

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM232202
PNG
((E)-N-Octyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H31NO4/c1-5-6-7-8-9-10-13-21-19(22)12-11-16-14-17(23-2)20(25-4)18(15-16)24-3/h11-12,14-15H,5-10,13H2,1-4H3,(H,21,22)/b12-11+
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n/an/a 1.20E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For the binding assay, aliquots of receptor membranes, 0.25 nM [3H]8-OH-DPAT (8-hydroxy-2-(di-N-propylamino)tetralin, 154.3 Ci/mM; New England Nuclea...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM232203
PNG
((E)-N-Decyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H35NO4/c1-5-6-7-8-9-10-11-12-15-23-21(24)14-13-18-16-19(25-2)22(27-4)20(17-18)26-3/h13-14,16-17H,5-12,15H2,1-4H3,(H,23,24)/b14-13+
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n/an/a 2.10E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For the binding assay, aliquots of receptor membranes, 0.25 nM [3H]8-OH-DPAT (8-hydroxy-2-(di-N-propylamino)tetralin, 154.3 Ci/mM; New England Nuclea...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM232204
PNG
(3,4,5-Trimethoxycinnamic acid (TMCA))
Show SMILES COc1cc(\C=C\C(O)=O)cc(OC)c1OC
Show InChI InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+
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n/an/a 2.50E+3n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
Frozen membranes from a stable CHO-K1 cell line expressing the human recombinant 5-HT2C receptor (PerkinElmer) were used. For the binding assay, [3H]...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM232201
PNG
((E)-N-Hexyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C18H27NO4/c1-5-6-7-8-11-19-17(20)10-9-14-12-15(21-2)18(23-4)16(13-14)22-3/h9-10,12-13H,5-8,11H2,1-4H3,(H,19,20)/b10-9+
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n/an/a 3.80E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For the binding assay, aliquots of receptor membranes, 0.25 nM [3H]8-OH-DPAT (8-hydroxy-2-(di-N-propylamino)tetralin, 154.3 Ci/mM; New England Nuclea...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM232203
PNG
((E)-N-Decyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H35NO4/c1-5-6-7-8-9-10-11-12-15-23-21(24)14-13-18-16-19(25-2)22(27-4)20(17-18)26-3/h13-14,16-17H,5-12,15H2,1-4H3,(H,23,24)/b14-13+
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n/an/a 4.50E+3n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
Frozen membranes from a stable CHO-K1 cell line expressing the human recombinant 5-HT2C receptor (PerkinElmer) were used. For the binding assay, [3H]...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM232200
PNG
((E)-N-Butyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C16H23NO4/c1-5-6-9-17-15(18)8-7-12-10-13(19-2)16(21-4)14(11-12)20-3/h7-8,10-11H,5-6,9H2,1-4H3,(H,17,18)/b8-7+
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n/an/a 4.90E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For the binding assay, aliquots of receptor membranes, 0.25 nM [3H]8-OH-DPAT (8-hydroxy-2-(di-N-propylamino)tetralin, 154.3 Ci/mM; New England Nuclea...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM232198
PNG
((E)-N-Methyl-3-(3,4,5-trimethoxyphenyl) acrylamide...)
Show SMILES CNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C13H17NO4/c1-14-12(15)6-5-9-7-10(16-2)13(18-4)11(8-9)17-3/h5-8H,1-4H3,(H,14,15)/b6-5+
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n/an/a 5.60E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For the binding assay, aliquots of receptor membranes, 0.25 nM [3H]8-OH-DPAT (8-hydroxy-2-(di-N-propylamino)tetralin, 154.3 Ci/mM; New England Nuclea...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM232203
PNG
((E)-N-Decyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H35NO4/c1-5-6-7-8-9-10-11-12-15-23-21(24)14-13-18-16-19(25-2)22(27-4)20(17-18)26-3/h13-14,16-17H,5-12,15H2,1-4H3,(H,23,24)/b14-13+
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n/an/a 5.60E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM232199
PNG
((E)-N-Allyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES COc1cc(\C=C\C(=O)NCC=C)cc(OC)c1OC
Show InChI InChI=1S/C15H19NO4/c1-5-8-16-14(17)7-6-11-9-12(18-2)15(20-4)13(10-11)19-3/h5-7,9-10H,1,8H2,2-4H3,(H,16,17)/b7-6+
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n/an/a 5.90E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For the binding assay, aliquots of receptor membranes, 0.25 nM [3H]8-OH-DPAT (8-hydroxy-2-(di-N-propylamino)tetralin, 154.3 Ci/mM; New England Nuclea...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM232203
PNG
((E)-N-Decyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H35NO4/c1-5-6-7-8-9-10-11-12-15-23-21(24)14-13-18-16-19(25-2)22(27-4)20(17-18)26-3/h13-14,16-17H,5-12,15H2,1-4H3,(H,23,24)/b14-13+
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n/an/a 6.70E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM232203
PNG
((E)-N-Decyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C22H35NO4/c1-5-6-7-8-9-10-11-12-15-23-21(24)14-13-18-16-19(25-2)22(27-4)20(17-18)26-3/h13-14,16-17H,5-12,15H2,1-4H3,(H,23,24)/b14-13+
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n/an/a 6.80E+3n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
For serotonin 5-HT2A binding, an aliquot of frozen membrane from a CHO-K1 cell line expressing the human recombinant 5-HT2A receptor (PerkinElmer) an...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM232204
PNG
(3,4,5-Trimethoxycinnamic acid (TMCA))
Show SMILES COc1cc(\C=C\C(O)=O)cc(OC)c1OC
Show InChI InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+
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n/an/a 7.60E+3n/an/an/an/a7.427



Ewha Womans University



Assay Description
For the binding assay, aliquots of receptor membranes, 0.25 nM [3H]8-OH-DPAT (8-hydroxy-2-(di-N-propylamino)tetralin, 154.3 Ci/mM; New England Nuclea...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM232202
PNG
((E)-N-Octyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H31NO4/c1-5-6-7-8-9-10-13-21-19(22)12-11-16-14-17(23-2)20(25-4)18(15-16)24-3/h11-12,14-15H,5-10,13H2,1-4H3,(H,21,22)/b12-11+
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n/an/a 8.80E+3n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
Frozen membranes from a stable CHO-K1 cell line expressing the human recombinant 5-HT2C receptor (PerkinElmer) were used. For the binding assay, [3H]...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM232198
PNG
((E)-N-Methyl-3-(3,4,5-trimethoxyphenyl) acrylamide...)
Show SMILES CNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C13H17NO4/c1-14-12(15)6-5-9-7-10(16-2)13(18-4)11(8-9)17-3/h5-8H,1-4H3,(H,14,15)/b6-5+
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Ewha Womans University



Assay Description
Frozen membranes from a stable CHO-K1 cell line expressing the human recombinant 5-HT2C receptor (PerkinElmer) were used. For the binding assay, [3H]...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM232201
PNG
((E)-N-Hexyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C18H27NO4/c1-5-6-7-8-11-19-17(20)10-9-14-12-15(21-2)18(23-4)16(13-14)22-3/h9-10,12-13H,5-8,11H2,1-4H3,(H,19,20)/b10-9+
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Ewha Womans University



Assay Description
Frozen membranes from a stable CHO-K1 cell line expressing the human recombinant 5-HT2C receptor (PerkinElmer) were used. For the binding assay, [3H]...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM232198
PNG
((E)-N-Methyl-3-(3,4,5-trimethoxyphenyl) acrylamide...)
Show SMILES CNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C13H17NO4/c1-14-12(15)6-5-9-7-10(16-2)13(18-4)11(8-9)17-3/h5-8H,1-4H3,(H,14,15)/b6-5+
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM232199
PNG
((E)-N-Allyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES COc1cc(\C=C\C(=O)NCC=C)cc(OC)c1OC
Show InChI InChI=1S/C15H19NO4/c1-5-8-16-14(17)7-6-11-9-12(18-2)15(20-4)13(10-11)19-3/h5-7,9-10H,1,8H2,2-4H3,(H,16,17)/b7-6+
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Ewha Womans University



Assay Description
For serotonin 5-HT2A binding, an aliquot of frozen membrane from a CHO-K1 cell line expressing the human recombinant 5-HT2A receptor (PerkinElmer) an...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM232200
PNG
((E)-N-Butyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C16H23NO4/c1-5-6-9-17-15(18)8-7-12-10-13(19-2)16(21-4)14(11-12)20-3/h7-8,10-11H,5-6,9H2,1-4H3,(H,17,18)/b8-7+
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM232202
PNG
((E)-N-Octyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H31NO4/c1-5-6-7-8-9-10-13-21-19(22)12-11-16-14-17(23-2)20(25-4)18(15-16)24-3/h11-12,14-15H,5-10,13H2,1-4H3,(H,21,22)/b12-11+
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Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM232199
PNG
((E)-N-Allyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES COc1cc(\C=C\C(=O)NCC=C)cc(OC)c1OC
Show InChI InChI=1S/C15H19NO4/c1-5-8-16-14(17)7-6-11-9-12(18-2)15(20-4)13(10-11)19-3/h5-7,9-10H,1,8H2,2-4H3,(H,16,17)/b7-6+
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM232200
PNG
((E)-N-Butyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C16H23NO4/c1-5-6-9-17-15(18)8-7-12-10-13(19-2)16(21-4)14(11-12)20-3/h7-8,10-11H,5-6,9H2,1-4H3,(H,17,18)/b8-7+
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM232202
PNG
((E)-N-Octyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H31NO4/c1-5-6-7-8-9-10-13-21-19(22)12-11-16-14-17(23-2)20(25-4)18(15-16)24-3/h11-12,14-15H,5-10,13H2,1-4H3,(H,21,22)/b12-11+
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM232204
PNG
(3,4,5-Trimethoxycinnamic acid (TMCA))
Show SMILES COc1cc(\C=C\C(O)=O)cc(OC)c1OC
Show InChI InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+
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UniChem
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM232200
PNG
((E)-N-Butyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C16H23NO4/c1-5-6-9-17-15(18)8-7-12-10-13(19-2)16(21-4)14(11-12)20-3/h7-8,10-11H,5-6,9H2,1-4H3,(H,17,18)/b8-7+
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
Frozen membranes from a stable CHO-K1 cell line expressing the human recombinant 5-HT2C receptor (PerkinElmer) were used. For the binding assay, [3H]...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM232204
PNG
(3,4,5-Trimethoxycinnamic acid (TMCA))
Show SMILES COc1cc(\C=C\C(O)=O)cc(OC)c1OC
Show InChI InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
For serotonin 5-HT2A binding, an aliquot of frozen membrane from a CHO-K1 cell line expressing the human recombinant 5-HT2A receptor (PerkinElmer) an...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM232201
PNG
((E)-N-Hexyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C18H27NO4/c1-5-6-7-8-11-19-17(20)10-9-14-12-15(21-2)18(23-4)16(13-14)22-3/h9-10,12-13H,5-8,11H2,1-4H3,(H,19,20)/b10-9+
PDB
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
For serotonin 5-HT2A binding, an aliquot of frozen membrane from a CHO-K1 cell line expressing the human recombinant 5-HT2A receptor (PerkinElmer) an...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM232200
PNG
((E)-N-Butyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C16H23NO4/c1-5-6-9-17-15(18)8-7-12-10-13(19-2)16(21-4)14(11-12)20-3/h7-8,10-11H,5-6,9H2,1-4H3,(H,17,18)/b8-7+
PDB
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UniChem
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
For serotonin 5-HT2A binding, an aliquot of frozen membrane from a CHO-K1 cell line expressing the human recombinant 5-HT2A receptor (PerkinElmer) an...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM232199
PNG
((E)-N-Allyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES COc1cc(\C=C\C(=O)NCC=C)cc(OC)c1OC
Show InChI InChI=1S/C15H19NO4/c1-5-8-16-14(17)7-6-11-9-12(18-2)15(20-4)13(10-11)19-3/h5-7,9-10H,1,8H2,2-4H3,(H,16,17)/b7-6+
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM232202
PNG
((E)-N-Octyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C20H31NO4/c1-5-6-7-8-9-10-13-21-19(22)12-11-16-14-17(23-2)20(25-4)18(15-16)24-3/h11-12,14-15H,5-10,13H2,1-4H3,(H,21,22)/b12-11+
PDB
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
For serotonin 5-HT2A binding, an aliquot of frozen membrane from a CHO-K1 cell line expressing the human recombinant 5-HT2A receptor (PerkinElmer) an...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (Human))
BDBM232198
PNG
((E)-N-Methyl-3-(3,4,5-trimethoxyphenyl) acrylamide...)
Show SMILES CNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C13H17NO4/c1-14-12(15)6-5-9-7-10(16-2)13(18-4)11(8-9)17-3/h5-8H,1-4H3,(H,14,15)/b6-5+
PDB
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
For serotonin 5-HT2A binding, an aliquot of frozen membrane from a CHO-K1 cell line expressing the human recombinant 5-HT2A receptor (PerkinElmer) an...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM232199
PNG
((E)-N-Allyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES COc1cc(\C=C\C(=O)NCC=C)cc(OC)c1OC
Show InChI InChI=1S/C15H19NO4/c1-5-8-16-14(17)7-6-11-9-12(18-2)15(20-4)13(10-11)19-3/h5-7,9-10H,1,8H2,2-4H3,(H,16,17)/b7-6+
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UniChem
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Ewha Womans University



Assay Description
Frozen membranes from a stable CHO-K1 cell line expressing the human recombinant 5-HT2C receptor (PerkinElmer) were used. For the binding assay, [3H]...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM232201
PNG
((E)-N-Hexyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C18H27NO4/c1-5-6-7-8-11-19-17(20)10-9-14-12-15(21-2)18(23-4)16(13-14)22-3/h9-10,12-13H,5-8,11H2,1-4H3,(H,19,20)/b10-9+
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM232198
PNG
((E)-N-Methyl-3-(3,4,5-trimethoxyphenyl) acrylamide...)
Show SMILES CNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C13H17NO4/c1-14-12(15)6-5-9-7-10(16-2)13(18-4)11(8-9)17-3/h5-8H,1-4H3,(H,14,15)/b6-5+
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UniChem
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM232204
PNG
(3,4,5-Trimethoxycinnamic acid (TMCA))
Show SMILES COc1cc(\C=C\C(O)=O)cc(OC)c1OC
Show InChI InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)/b5-4+
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UniChem
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM232201
PNG
((E)-N-Hexyl-3-(3,4,5-trimethoxyphenyl) acrylamide ...)
Show SMILES CCCCCCNC(=O)\C=C\c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C18H27NO4/c1-5-6-7-8-11-19-17(20)10-9-14-12-15(21-2)18(23-4)16(13-14)22-3/h9-10,12-13H,5-8,11H2,1-4H3,(H,19,20)/b10-9+
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UniChem
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n/an/a>1.00E+4n/an/an/an/a7.427



Ewha Womans University



Assay Description
For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...


J Enzyme Inhib Med Chem 25: 38-43 (2010)


Article DOI: 10.3109/14756360902932784
BindingDB Entry DOI: 10.7270/Q2F76BDV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%