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Found 26 Enz. Inhib. hit(s) with all data for entry = 50030804
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301711((1R,2R)-2-(5-(3-methoxyphenyl)isoxazol-3-yl)-N-(1-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301729((1R,2R)-N-(1-(4-fluorophenyl)cyclobutyl)-2-(5-phen...)
Affinity DataIC50:  84nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301728((1R,2R)-N-(1-(3-fluorophenyl)cyclobutyl)-2-(5-phen...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301723((1R,2R)-N-(1-phenylcyclobutyl)-2-(5-phenylisoxazol...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301714((1R,2R)-2-(5-(4-hydroxyphenyl)isoxazol-3-yl)-N-(1-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301732((1R,2R)-N-(3-fluoro-1-phenylcyclobutyl)-2-(5-pheny...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301712((1R,2R)-2-(5-(4-methoxyphenyl)isoxazol-3-yl)-N-(1-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301733((1R,2R)-2-(5-(2-chlorophenyl)isoxazol-3-yl)-N-(1-p...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301718((1R,2R)-2-(5-(6-methoxypyridin-2-yl)isoxazol-3-yl)...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301713((1R,2R)-2-(5-(3-hydroxyphenyl)isoxazol-3-yl)-N-(1-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301724((1R,2R)-N-(1-phenylcyclopentyl)-2-(5-phenylisoxazo...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301719((1R,2R)-N-(1-phenylcyclobutyl)-2-(5-(6-(trifluorom...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301715((1R,2R)-2-(5-(2-hydroxy-3-(trifluoromethoxy)phenyl...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301717((1R,2R)-2-(5-(2-hydroxy-4-(trifluoromethyl)phenyl)...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301709((1R,2R)-N-(1-phenylcyclobutyl)-2-(5-(3-(trifluorom...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301731((1R,2R)-N-(3-methoxy-1-phenylcyclobutyl)-2-(5-phen...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301710((1R,2R)-2-(5-(2-methoxyphenyl)isoxazol-3-yl)-N-(1-...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301721((1R,2R)-2-(5-phenylisoxazol-3-yl)-N-(2-phenylpropa...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301722((1R,2R)-N-(1-phenylcyclopropyl)-2-(5-phenylisoxazo...)
Affinity DataIC50:  440nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301727((1R,2R)-N-(1-(2-fluorophenyl)cyclobutyl)-2-(5-phen...)
Affinity DataIC50:  450nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301725((1R,2R)-N-(1-phenylcyclohexyl)-2-(5-phenylisoxazol...)
Affinity DataIC50:  580nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301726((1R,2R)-2-(5-phenylisoxazol-3-yl)-N-(1-(3-(trifluo...)
Affinity DataIC50:  590nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301734((1R,2R)-N-(1-phenylcyclobutyl)-2-(5-(2-(trifluorom...)
Affinity DataIC50:  740nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301720((1R,2R)-N-(1-phenylethyl)-2-(5-phenylisoxazol-3-yl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301730((1R,2R)-N-(3-hydroxy-1-phenylcyclobutyl)-2-(5-phen...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50301716((1R,2R)-2-(5-(2-hydroxy-3-(trifluoromethyl)phenyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed