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Found 16 Enz. Inhib. hit(s) with all data for entry = 50031481
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314023((6S,9S,12S,15S,18S,21S)-21-acetamido-1,26-diamino-...)
Affinity DataIC50:  250nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314024((6S,9S,12S,15S,18S,21S)-21-acetamido-1,26-diamino-...)
Affinity DataIC50:  600nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314027((6S,9S,12S,15S,18S)-1-amino-1-imino-12,15,18-triis...)
Affinity DataIC50:  3.00E+3nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314028((6S,9S,12S,15S,18S,21S)-21-((1H-imidazol-5-yl)meth...)
Affinity DataIC50:  3.00E+3nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314033((6S,9S,12S,15S,18S,21S,24S)-21-((1H-imidazol-5-yl)...)
Affinity DataIC50:  4.00E+3nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314032((2S,5S,8S,11S,14S,17S,20S)-17-((1H-imidazol-5-yl)m...)
Affinity DataIC50:  5.00E+3nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314031((6S,9S,12S,15S,18S,21S,24S)-21-((1H-imidazol-5-yl)...)
Affinity DataIC50:  5.00E+3nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314025((6S,12S,15S,18S,21S)-21-acetamido-1,26-diamino-1,2...)
Affinity DataIC50:  7.00E+3nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314023((6S,9S,12S,15S,18S,21S)-21-acetamido-1,26-diamino-...)
Affinity DataIC50:  1.00E+4nMpH: 7.4Assay Description:Inhibition of human C3 convertase assessed as inhibition of C3a and C3b fragment production at pH 7.4 after 30 mins by SDS-PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314026((6S,9S,12S,15S)-1-amino-1-imino-12,15-diisobutyl-9...)
Affinity DataIC50:  1.20E+4nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50241352(2-[(4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-34-[(2S...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human C3/C5 convertase assessed as inhibition of C3 cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314030((6S,9S,12S,18S,21S,24S)-21-((1H-imidazol-5-yl)meth...)
Affinity DataIC50:  1.30E+4nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314035((S)-2-[(S)-2-((S)-2-Acetylamino-3-hydroxy-propiony...)
Affinity DataIC50:  1.90E+4nMpH: 9.5Assay Description:Inhibition of human complement factor B at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314034((6S,9S,12S,18S,21S,24S)-21-((1H-imidazol-5-yl)meth...)
Affinity DataIC50:  1.90E+4nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314029((6S,9S,12S,18S,21S,24S)-21-((1H-imidazol-5-yl)meth...)
Affinity DataIC50:  2.30E+4nMpH: 9.5Assay Description:Inhibition of human complement factor B treated for 5 mins before addition of substrate Ac-SHLGLAR-pNA at pH 9.5 by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50314024((6S,9S,12S,15S,18S,21S)-21-acetamido-1,26-diamino-...)
Affinity DataIC50:  5.00E+4nMpH: 7.4Assay Description:Inhibition of human C3 convertase assessed as inhibition of C3a and C3b fragment production at pH 7.4 after 30 mins by SDS-PAGEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed