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Found 23 Enz. Inhib. hit(s) with all data for entry = 50039068
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  0.0210nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  0.0410nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50209771(3,4-dihydroquinolin-2(1H)-one | CHEMBL388582 | Dih...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50308509(4-(4-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazo...)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of mouse COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM15239(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM15238(4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
King'S College London

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  68nMAssay Description:Inhibition of mouse COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50074933(2-biphenyl-4-yl-propionic acid | CHEMBL317434 | al...)
Affinity DataIC50:  110nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM15237(4-[1-(cyclopropylmethyl)-4-(4-fluorophenyl)-1H-imi...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14769(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50308512((5R)-5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-ox...)
Affinity DataIC50:  420nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataIC50:  500nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataIC50:  500nMAssay Description:Inhibition of mouse COX2More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50308511(1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACET...)
Affinity DataIC50:  780nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14771((E)-{1-[3-(cyclopentyloxy)-4-methoxyphenyl]ethylid...)
Affinity DataIC50:  960nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
King'S College London

Curated by ChEMBL
LigandPNGBDBM50308510(CHEMBL589253 | Iodosuprofen)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of ovine COX1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM13337(3-(benzyloxy)pyridin-2-amine | EN300-247019 | Pyri...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human MAPK p38alphaMore data for this Ligand-Target Pair