Compile Data Set for Download or QSAR
maximum 50k data
Found 47 Enz. Inhib. hit(s) with all data for entry = 50031515
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314606((5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-met...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314609(3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-di...)
Affinity DataIC50:  40nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314609(3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-di...)
Affinity DataIC50:  40nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314611(2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314604((+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-me...)
Affinity DataIC50:  50nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314610(2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyr...)
Affinity DataIC50:  50nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310155(2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyr...)
Affinity DataIC50:  60nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  60nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  60nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314612(2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...)
Affinity DataIC50:  70nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314610(2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyr...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314606((5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-met...)
Affinity DataIC50:  100nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314604((+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-me...)
Affinity DataIC50:  120nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310149(2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl...)
Affinity DataIC50:  130nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314611(2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  130nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314608(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3'-(trifluoro...)
Affinity DataIC50:  140nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310149(2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314601(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3-(thiophen-3...)
Affinity DataIC50:  190nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314601(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3-(thiophen-3...)
Affinity DataIC50:  240nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314608(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3'-(trifluoro...)
Affinity DataIC50:  250nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310155(2-amino-1-methyl-4-(3-(pyridin-3-yl)phenyl)-4-(pyr...)
Affinity DataIC50:  480nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314602(2-amino-4-(3-(furan-3-yl)phenyl)-1-methyl-4-(pyrid...)
Affinity DataIC50:  570nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314602(2-amino-4-(3-(furan-3-yl)phenyl)-1-methyl-4-(pyrid...)
Affinity DataIC50:  630nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314605((R)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50:  700nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314612(2-amino-1-methyl-4-(3-(pyrazin-2-yl)phenyl)-4-(pyr...)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310154(2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imid...)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310154(2-amino-1-methyl-4-phenyl-4-(pyridin-4-yl)-1H-imid...)
Affinity DataIC50:  2.68E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300229(1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-am...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314605((R)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50:  3.81E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314606((5S)-2-amino-5-(2',5'-difluorobiphenyl-3-yl)-3-met...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314604((+/-)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-me...)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314607(2-amino-4-(3'-methoxybiphenyl-3-yl)-1-methyl-4-(py...)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314611(2-amino-4-(2',3'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  1.31E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314608(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3'-(trifluoro...)
Affinity DataIC50:  1.41E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314603(2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methy...)
Affinity DataIC50:  1.74E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314610(2-amino-4-(3'-fluorobiphenyl-3-yl)-1-methyl-4-(pyr...)
Affinity DataIC50:  2.08E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314609(3'-(2-amino-1-methyl-5-oxo-4-(pyridin-4-yl)-4,5-di...)
Affinity DataIC50:  2.42E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314605((R)-2-amino-4-(2',5'-difluorobiphenyl-3-yl)-1-meth...)
Affinity DataIC50:  2.64E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50310149(2-amino-4-(biphenyl-3-yl)-1-methyl-4-(pyridin-4-yl...)
Affinity DataIC50:  3.01E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314601(2-amino-1-methyl-4-(pyridin-4-yl)-4-(3-(thiophen-3...)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314600(2-amino-4-(3',5'-difluorobiphenyl-3-yl)-1-methyl-4...)
Affinity DataIC50:  3.41E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300710(8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrim...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50314602(2-amino-4-(3-(furan-3-yl)phenyl)-1-methyl-4-(pyrid...)
Affinity DataIC50:  4.68E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed