Compile Data Set for Download or QSAR
maximum 50k data
Found 36 Enz. Inhib. hit(s) with all data for entry = 50039134
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataIC50:  7nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316567(1-(2-chloropyridin-4-yl)-2,2,2-trifluoro-1-(1-(4-f...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316565(1-(2-chlorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorop...)
Affinity DataIC50:  35nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316558(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5...)
Affinity DataIC50:  52nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataIC50:  54nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316564(2,2,2-trifluoro-1-(2-fluorophenyl)-1-(1-(4-fluorop...)
Affinity DataIC50:  54nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316569(2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...)
Affinity DataIC50:  59nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316559(1-(3-chlorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorop...)
Affinity DataIC50:  72nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316555(2,2,2-trifluoro-1-(4-fluorophenyl)-1-(1-(4-fluorop...)
Affinity DataIC50:  86nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316555(2,2,2-trifluoro-1-(4-fluorophenyl)-1-(1-(4-fluorop...)
Affinity DataIC50:  86nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316566((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...)
Affinity DataIC50:  87nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316566((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...)
Affinity DataIC50:  87nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316560(3-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazo...)
Affinity DataIC50:  99nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataIC50:  117nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataIC50:  117nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316557(1-(3,4-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4-flu...)
Affinity DataIC50:  178nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316563(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5...)
Affinity DataIC50:  282nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316556(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5...)
Affinity DataIC50:  2.09E+3nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316554(1-(4-fluorophenyl)-1-(1-(4-fluorophenyl)-1H-indazo...)
Affinity DataIC50:  2.11E+3nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316555(2,2,2-trifluoro-1-(4-fluorophenyl)-1-(1-(4-fluorop...)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316566((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316553((4-fluorophenyl)(1-(4-fluorophenyl)-1H-indazol-5-y...)
Affinity DataIC50:  1.00E+4nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316569(2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316567(1-(2-chloropyridin-4-yl)-2,2,2-trifluoro-1-(1-(4-f...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316566((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...)
Affinity DataEC50:  350nMAssay Description:Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataEC50:  55nMAssay Description:Agonist activity at glucocorticoid receptor in human MDA-kb2 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316561(1-(2-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316569(2,2,2-trifluoro-1-(4-fluoro-3-methylphenyl)-1-(1-(...)
Affinity DataEC50:  93nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataEC50:  112nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316567(1-(2-chloropyridin-4-yl)-2,2,2-trifluoro-1-(1-(4-f...)
Affinity DataEC50:  627nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316566((+)-1-(2,3-dichlorophenyl)-2,2,2-trifluoro-1-(1-(4...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed