Compile Data Set for Download or QSAR
maximum 50k data
Found 60 Enz. Inhib. hit(s) with all data for entry = 50031800
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319571(CHEMBL1084451 | N-(4-(3-(2-((1-ethylpiperidin-4-yl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266221(CHEMBL458023 | N-(3-methyl-4-(3-(2-(methylamino)py...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(CHEMBL1084452 | N-(4-(3-(2-(2-(1-methylpyrrolidin-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266149(1-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266187(CHEMBL456463 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  19nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266149(1-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266187(CHEMBL456463 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  25nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266221(CHEMBL458023 | N-(3-methyl-4-(3-(2-(methylamino)py...)
Affinity DataIC50:  29nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266187(CHEMBL456463 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  30nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266149(1-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50:  40nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266188(CHEMBL456683 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  44nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(CHEMBL1084452 | N-(4-(3-(2-(2-(1-methylpyrrolidin-...)
Affinity DataIC50:  47nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50:  48nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266149(1-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50:  48nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266149(1-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-y...)
Affinity DataIC50:  52nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  56nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266221(CHEMBL458023 | N-(3-methyl-4-(3-(2-(methylamino)py...)
Affinity DataIC50:  77nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266188(CHEMBL456683 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319573(CHEMBL1084453 | N1-(4-(2-(4-(1H-benzo[d]imidazol-2...)
Affinity DataIC50:  82nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319574(CHEMBL1086334 | N-(4-(3-(2-(methylamino)pyrimidin-...)
Affinity DataIC50:  86nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266188(CHEMBL456683 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  88nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319571(CHEMBL1084451 | N-(4-(3-(2-((1-ethylpiperidin-4-yl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266185(CHEMBL463323 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  132nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266187(CHEMBL456463 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  134nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266187(CHEMBL456463 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  141nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266188(CHEMBL456683 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  143nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50:  215nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319569(1-tert-butyl-3-(4-(3-(2-(methylamino)pyrimidin-4-y...)
Affinity DataIC50:  225nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50:  248nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(CHEMBL1084452 | N-(4-(3-(2-(2-(1-methylpyrrolidin-...)
Affinity DataIC50:  269nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  292nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319572(CHEMBL1084452 | N-(4-(3-(2-(2-(1-methylpyrrolidin-...)
Affinity DataIC50:  327nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319571(CHEMBL1084451 | N-(4-(3-(2-((1-ethylpiperidin-4-yl...)
Affinity DataIC50:  332nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266188(CHEMBL456683 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  380nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319571(CHEMBL1084451 | N-(4-(3-(2-((1-ethylpiperidin-4-yl...)
Affinity DataIC50:  387nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266221(CHEMBL458023 | N-(3-methyl-4-(3-(2-(methylamino)py...)
Affinity DataIC50:  405nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319574(CHEMBL1086334 | N-(4-(3-(2-(methylamino)pyrimidin-...)
Affinity DataIC50:  454nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319570(1-ethyl-3-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyr...)
Affinity DataIC50:  534nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319573(CHEMBL1084453 | N1-(4-(2-(4-(1H-benzo[d]imidazol-2...)
Affinity DataIC50:  759nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319574(CHEMBL1086334 | N-(4-(3-(2-(methylamino)pyrimidin-...)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50266148(CHEMBL465793 | N-(4-(3-(2-(methylamino)pyrimidin-4...)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50319573(CHEMBL1084453 | N1-(4-(2-(4-(1H-benzo[d]imidazol-2...)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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