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PubMed code 20666436

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93422
PNG
(PHD Inhibitor, 12{1,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93422
PNG
(PHD Inhibitor, 12{1,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m0/s1
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Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93425
PNG
(PHD Inhibitor, 12{4,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H31N5O8/c1-17(37)35-23(13-18-7-9-20-5-3-4-6-21(20)11-18)29(42)33-15-25(38)32-14-19-8-10-24-22(12-19)28(41)27(31(44)36(24)2)30(43)34-16-26(39)40/h3-12,23,41H,13-16H2,1-2H3,(H,32,38)(H,33,42)(H,34,43)(H,35,37)(H,39,40)/t23-/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93430
PNG
(PHD Inhibitor, 12{2,1,2})
Show SMILES CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m1/s1
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n/an/a 6.40n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93426
PNG
(PHD Inhibitor, 12{2,5,2})
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26+/m1/s1
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n/an/a 7.60n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 8.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93426
PNG
(PHD Inhibitor, 12{2,5,2})
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26+/m1/s1
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Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93427
PNG
(PHD Inhibitor, 12{2,6,2})
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H37N5O8/c1-17(2)12-22(34-18(3)37)29(42)35-23(14-19-8-6-5-7-9-19)28(41)32-15-20-10-11-24-21(13-20)27(40)26(31(44)36(24)4)30(43)33-16-25(38)39/h5-11,13,17,22-23,40H,12,14-16H2,1-4H3,(H,32,41)(H,33,43)(H,34,37)(H,35,42)(H,38,39)/t22-,23+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 11.7n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 12.2n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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n/an/a 12.9n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93430
PNG
(PHD Inhibitor, 12{2,1,2})
Show SMILES CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m1/s1
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n/an/a 13.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 13.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93425
PNG
(PHD Inhibitor, 12{4,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H31N5O8/c1-17(37)35-23(13-18-7-9-20-5-3-4-6-21(20)11-18)29(42)33-15-25(38)32-14-19-8-10-24-22(12-19)28(41)27(31(44)36(24)2)30(43)34-16-26(39)40/h3-12,23,41H,13-16H2,1-2H3,(H,32,38)(H,33,42)(H,34,43)(H,35,37)(H,39,40)/t23-/m0/s1
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n/an/a 13.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93432
PNG
(PHD Inhibitor, 12{2,6,4})
Show SMILES CC(C)C[C@@H](NC(=O)C(C)(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H43N5O8/c1-19(2)14-23(38-33(47)34(3,4)5)30(44)37-24(16-20-10-8-7-9-11-20)29(43)35-17-21-12-13-25-22(15-21)28(42)27(32(46)39(25)6)31(45)36-18-26(40)41/h7-13,15,19,23-24,42H,14,16-18H2,1-6H3,(H,35,43)(H,36,45)(H,37,44)(H,38,47)(H,40,41)/t23-,24-/m1/s1
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n/an/a 14.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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n/an/a 14.6n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93427
PNG
(PHD Inhibitor, 12{2,6,2})
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H37N5O8/c1-17(2)12-22(34-18(3)37)29(42)35-23(14-19-8-6-5-7-9-19)28(41)32-15-20-10-11-24-21(13-20)27(40)26(31(44)36(24)4)30(43)33-16-25(38)39/h5-11,13,17,22-23,40H,12,14-16H2,1-4H3,(H,32,41)(H,33,43)(H,34,37)(H,35,42)(H,38,39)/t22-,23+/m0/s1
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n/an/a 16.2n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93432
PNG
(PHD Inhibitor, 12{2,6,4})
Show SMILES CC(C)C[C@@H](NC(=O)C(C)(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H43N5O8/c1-19(2)14-23(38-33(47)34(3,4)5)30(44)37-24(16-20-10-8-7-9-11-20)29(43)35-17-21-12-13-25-22(15-21)28(42)27(32(46)39(25)6)31(45)36-18-26(40)41/h7-13,15,19,23-24,42H,14,16-18H2,1-6H3,(H,35,43)(H,36,45)(H,37,44)(H,38,47)(H,40,41)/t23-,24-/m1/s1
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n/an/a 16.8n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93433
PNG
(PHD Inhibitor, 12{2,1,4})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc4ccccc4c3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C41H43N5O8/c1-41(2,3)40(54)45-31(21-25-14-16-27-12-8-9-13-28(27)18-25)37(51)44-30(20-24-10-6-5-7-11-24)36(50)42-22-26-15-17-32-29(19-26)35(49)34(39(53)46(32)4)38(52)43-23-33(47)48/h5-19,30-31,49H,20-23H2,1-4H3,(H,42,50)(H,43,52)(H,44,51)(H,45,54)(H,47,48)/t30-,31-/m1/s1
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n/an/a 18.8n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93420
PNG
(PHD Inhibitor, 12{3,1,4})
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(C)(C)C)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H45N5O8/c1-21(2)16-27(41-34(48)28(42-37(51)38(3,4)5)18-24-12-9-11-23-10-7-8-13-25(23)24)33(47)39-19-22-14-15-29-26(17-22)32(46)31(36(50)43(29)6)35(49)40-20-30(44)45/h7-15,17,21,27-28,46H,16,18-20H2,1-6H3,(H,39,47)(H,40,49)(H,41,48)(H,42,51)(H,44,45)/t27-,28-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93422
PNG
(PHD Inhibitor, 12{1,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 37.4n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 38.3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93418
PNG
(PHD Inhibitor, 12{2,3,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)C[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C40H39N5O8/c1-45-32-18-17-27(20-30(32)36(49)35(40(45)53)39(52)42-24-34(47)48)23-41-38(51)31(21-26-13-7-3-8-14-26)44-33(46)22-29(19-25-11-5-2-6-12-25)43-37(50)28-15-9-4-10-16-28/h2-18,20,29,31,49H,19,21-24H2,1H3,(H,41,51)(H,42,52)(H,43,50)(H,44,46)(H,47,48)/t29-,31+/m0/s1
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Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93425
PNG
(PHD Inhibitor, 12{4,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H31N5O8/c1-17(37)35-23(13-18-7-9-20-5-3-4-6-21(20)11-18)29(42)33-15-25(38)32-14-19-8-10-24-22(12-19)28(41)27(31(44)36(24)2)30(43)34-16-26(39)40/h3-12,23,41H,13-16H2,1-2H3,(H,32,38)(H,33,42)(H,34,43)(H,35,37)(H,39,40)/t23-/m0/s1
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n/an/a 41.9n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93426
PNG
(PHD Inhibitor, 12{2,5,2})
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26+/m1/s1
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n/an/a 44.8n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93418
PNG
(PHD Inhibitor, 12{2,3,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)C[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C40H39N5O8/c1-45-32-18-17-27(20-30(32)36(49)35(40(45)53)39(52)42-24-34(47)48)23-41-38(51)31(21-26-13-7-3-8-14-26)44-33(46)22-29(19-25-11-5-2-6-12-25)43-37(50)28-15-9-4-10-16-28/h2-18,20,29,31,49H,19,21-24H2,1H3,(H,41,51)(H,42,52)(H,43,50)(H,44,46)(H,47,48)/t29-,31+/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93433
PNG
(PHD Inhibitor, 12{2,1,4})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc4ccccc4c3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C41H43N5O8/c1-41(2,3)40(54)45-31(21-25-14-16-27-12-8-9-13-28(27)18-25)37(51)44-30(20-24-10-6-5-7-11-24)36(50)42-22-26-15-17-32-29(19-26)35(49)34(39(53)46(32)4)38(52)43-23-33(47)48/h5-19,30-31,49H,20-23H2,1-4H3,(H,42,50)(H,43,52)(H,44,51)(H,45,54)(H,47,48)/t30-,31-/m1/s1
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n/an/a 60.8n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93427
PNG
(PHD Inhibitor, 12{2,6,2})
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C31H37N5O8/c1-17(2)12-22(34-18(3)37)29(42)35-23(14-19-8-6-5-7-9-19)28(41)32-15-20-10-11-24-21(13-20)27(40)26(31(44)36(24)4)30(43)33-16-25(38)39/h5-11,13,17,22-23,40H,12,14-16H2,1-4H3,(H,32,41)(H,33,43)(H,34,37)(H,35,42)(H,38,39)/t22-,23+/m0/s1
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n/an/a 67.5n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93420
PNG
(PHD Inhibitor, 12{3,1,4})
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(C)(C)C)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H45N5O8/c1-21(2)16-27(41-34(48)28(42-37(51)38(3,4)5)18-24-12-9-11-23-10-7-8-13-25(23)24)33(47)39-19-22-14-15-29-26(17-22)32(46)31(36(50)43(29)6)35(49)40-20-30(44)45/h7-15,17,21,27-28,46H,16,18-20H2,1-6H3,(H,39,47)(H,40,49)(H,41,48)(H,42,51)(H,44,45)/t27-,28-/m0/s1
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n/an/a 77n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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n/an/a 86.4n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93423
PNG
(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
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n/an/a 90.2n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93430
PNG
(PHD Inhibitor, 12{2,1,2})
Show SMILES CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m1/s1
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n/an/a 93.8n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))
BDBM93421
PNG
(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/m0/s1
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n/an/a 95n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93428
PNG
(PHD Inhibitor, 12{2,3,4} | PHD Inhibitor, 12{2,4,4...)
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C37H41N5O8/c1-37(2,3)36(50)41-27(19-23-13-9-6-10-14-23)33(47)40-26(18-22-11-7-5-8-12-22)32(46)38-20-24-15-16-28-25(17-24)31(45)30(35(49)42(28)4)34(48)39-21-29(43)44/h5-17,26-27,45H,18-21H2,1-4H3,(H,38,46)(H,39,48)(H,40,47)(H,41,50)(H,43,44)/t26-,27-/m1/s1
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n/an/a 104n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93412
PNG
(PHD Inhibitor, 8{2})
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C25H26N4O7/c1-14(30)28-18(11-15-6-4-3-5-7-15)23(34)26-12-16-8-9-19-17(10-16)22(33)21(25(36)29(19)2)24(35)27-13-20(31)32/h3-10,18,33H,11-13H2,1-2H3,(H,26,34)(H,27,35)(H,28,30)(H,31,32)/t18-/m1/s1
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n/an/a 112n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93432
PNG
(PHD Inhibitor, 12{2,6,4})
Show SMILES CC(C)C[C@@H](NC(=O)C(C)(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H43N5O8/c1-19(2)14-23(38-33(47)34(3,4)5)30(44)37-24(16-20-10-8-7-9-11-20)29(43)35-17-21-12-13-25-22(15-21)28(42)27(32(46)39(25)6)31(45)36-18-26(40)41/h7-13,15,19,23-24,42H,14,16-18H2,1-6H3,(H,35,43)(H,36,45)(H,37,44)(H,38,47)(H,40,41)/t23-,24-/m1/s1
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n/an/a 113n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93416
PNG
(PHD Inhibitor, 8{6})
Show SMILES CC(=O)N[C@@H](CC(O)=O)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C20H22N4O9/c1-9(25)23-12(6-14(26)27)18(31)21-7-10-3-4-13-11(5-10)17(30)16(20(33)24(13)2)19(32)22-8-15(28)29/h3-5,12,30H,6-8H2,1-2H3,(H,21,31)(H,22,32)(H,23,25)(H,26,27)(H,28,29)/t12-/m0/s1
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n/an/a 138n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Prolyl hydroxylase EGLN3


(Homo sapiens (Human))
BDBM93421
PNG
(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/m0/s1
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n/an/a 165n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93415
PNG
(PHD Inhibitor, 8{5})
Show SMILES CC(=O)N[C@@H](CO)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C19H22N4O8/c1-9(25)22-12(8-24)17(29)20-6-10-3-4-13-11(5-10)16(28)15(19(31)23(13)2)18(30)21-7-14(26)27/h3-5,12,24,28H,6-8H2,1-2H3,(H,20,29)(H,21,30)(H,22,25)(H,26,27)/t12-/m0/s1
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n/an/a 265n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93414
PNG
(PHD Inhibitor, 8{4})
Show SMILES CC(=O)NCC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C18H20N4O7/c1-9(23)19-7-13(24)20-6-10-3-4-12-11(5-10)16(27)15(18(29)22(12)2)17(28)21-8-14(25)26/h3-5,27H,6-8H2,1-2H3,(H,19,23)(H,20,24)(H,21,28)(H,25,26)
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n/an/a 293n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93433
PNG
(PHD Inhibitor, 12{2,1,4})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc4ccccc4c3)NC(=O)C(C)(C)C)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C41H43N5O8/c1-41(2,3)40(54)45-31(21-25-14-16-27-12-8-9-13-28(27)18-25)37(51)44-30(20-24-10-6-5-7-11-24)36(50)42-22-26-15-17-32-29(19-26)35(49)34(39(53)46(32)4)38(52)43-23-33(47)48/h5-19,30-31,49H,20-23H2,1-4H3,(H,42,50)(H,43,52)(H,44,51)(H,45,54)(H,47,48)/t30-,31-/m1/s1
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n/an/a 308n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93417
PNG
(PHD Inhibitor, 8{7})
Show SMILES CC(=O)N[C@@H](CCCCN)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C22H29N5O7/c1-12(28)26-15(5-3-4-8-23)20(32)24-10-13-6-7-16-14(9-13)19(31)18(22(34)27(16)2)21(33)25-11-17(29)30/h6-7,9,15,31H,3-5,8,10-11,23H2,1-2H3,(H,24,32)(H,25,33)(H,26,28)(H,29,30)/t15-/m0/s1
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n/an/a 409n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93411
PNG
(PHD Inhibitor, 8{1})
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C25H26N4O7/c1-14(30)28-18(11-15-6-4-3-5-7-15)23(34)26-12-16-8-9-19-17(10-16)22(33)21(25(36)29(19)2)24(35)27-13-20(31)32/h3-10,18,33H,11-13H2,1-2H3,(H,26,34)(H,27,35)(H,28,30)(H,31,32)/t18-/m0/s1
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n/an/a 482n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93413
PNG
(PHD Inhibitor, 8{3})
Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C22H28N4O7/c1-11(2)7-15(25-12(3)27)20(31)23-9-13-5-6-16-14(8-13)19(30)18(22(33)26(16)4)21(32)24-10-17(28)29/h5-6,8,11,15,30H,7,9-10H2,1-4H3,(H,23,31)(H,24,32)(H,25,27)(H,28,29)/t15-/m1/s1
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n/an/a 521n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93410
PNG
(PHD Inhibitor, 5)
Show SMILES CC(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C16H17N3O6/c1-8(20)17-6-9-3-4-11-10(5-9)14(23)13(16(25)19(11)2)15(24)18-7-12(21)22/h3-5,23H,6-7H2,1-2H3,(H,17,20)(H,18,24)(H,21,22)
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n/an/a 546n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93419
PNG
(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
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n/an/a 622n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93420
PNG
(PHD Inhibitor, 12{3,1,4})
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)C(C)(C)C)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H45N5O8/c1-21(2)16-27(41-34(48)28(42-37(51)38(3,4)5)18-24-12-9-11-23-10-7-8-13-25(23)24)33(47)39-19-22-14-15-29-26(17-22)32(46)31(36(50)43(29)6)35(49)40-20-30(44)45/h7-15,17,21,27-28,46H,16,18-20H2,1-6H3,(H,39,47)(H,40,49)(H,41,48)(H,42,51)(H,44,45)/t27-,28-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93418
PNG
(PHD Inhibitor, 12{2,3,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)C[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C40H39N5O8/c1-45-32-18-17-27(20-30(32)36(49)35(40(45)53)39(52)42-24-34(47)48)23-41-38(51)31(21-26-13-7-3-8-14-26)44-33(46)22-29(19-25-11-5-2-6-12-25)43-37(50)28-15-9-4-10-16-28/h2-18,20,29,31,49H,19,21-24H2,1H3,(H,41,51)(H,42,52)(H,43,50)(H,44,46)(H,47,48)/t29-,31+/m0/s1
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n/an/a 1.56E+3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM93421
PNG
(PHD Inhibitor, 12{1,5,3})
Show SMILES Cn1c2ccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCN3CCOCC3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H44N6O9/c1-44-31-13-12-27(20-28(31)35(49)34(39(44)53)38(52)41-24-33(47)48)23-40-36(50)29(21-25-8-4-2-5-9-25)43-37(51)30(22-26-10-6-3-7-11-26)42-32(46)14-15-45-16-18-54-19-17-45/h2-13,20,29-30,49H,14-19,21-24H2,1H3,(H,40,50)(H,41,52)(H,42,46)(H,43,51)(H,47,48)/t29-,30-/m0/s1
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n/an/a 2.92E+3n/an/an/an/an/an/a



Amgen Inc



Assay Description
PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...


J Comb Chem 12: 676-86 (2010)


Article DOI: 10.1021/cc100073a
BindingDB Entry DOI: 10.7270/Q2B27SXP
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%