Compile Data Set for Download or QSAR
maximum 50k data
Found 57 Enz. Inhib. hit(s) with all data for entry = 50032574
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  60nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331273(3-(6-methyl-1H-indol-2-yl)-1H-indazole-6-carbonitr...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331280(3-(6-methyl-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyrid...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331269(3-(1H-indol-2-yl)-1H-indazole-6-carbonitrile | CHE...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331268(3-(1H-indol-2-yl)-1H-indazole-5-carbonitrile | CHE...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331274(6-fluoro-3-(6-methoxy-1H-indol-2-yl)-1H-indazole |...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331271(6-methyl-3-(6-methyl-1H-indol-2-yl)-1H-indazole | ...)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331262(3-(6-methyl-1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331258(3-(5-methoxy-1H-indol-2-yl)-1H-indazole | CHEMBL12...)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331259(3-(6-methoxy-1H-indol-2-yl)-1H-indazole | CHEMBL12...)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331272(6-fluoro-3-(6-methyl-1H-indol-2-yl)-1H-indazole | ...)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331257(3-(1H-indol-2-yl)-1H-indazole | CHEMBL1288974)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331265(3-(1H-indol-2-yl)-6-methyl-1H-indazole | CHEMBL128...)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331266(5-fluoro-3-(1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  190nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331267(6-fluoro-3-(1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331275(3-(1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine | CHE...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331282(3-(6-bromo-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridi...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331281(3-(4-bromo-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridi...)
Affinity DataIC50:  240nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331264(3-(1H-indol-2-yl)-5-methyl-1H-indazole | CHEMBL128...)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331276(3-(5-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331279(3-(5-methyl-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyrid...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  310nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331270(5-methyl-3-(6-methyl-1H-indol-2-yl)-1H-indazole | ...)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331261(3-(5-methyl-1H-indol-2-yl)-1H-indazole | CHEMBL128...)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of CDK4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331283(CHEMBL1288651 | N-(4-methoxyphenyl)-1H-indazole-3-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of PDGFR-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  3.22E+3nMAssay Description:Inhibition of NEK-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  3.82E+3nMAssay Description:Inhibition of SAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331263(2-(1H-indazol-3-yl)-1H-indole-6-carboxylic acid | ...)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  5.23E+3nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  5.38E+3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  5.49E+3nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  5.72E+3nMAssay Description:Inhibition of WEE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  5.94E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  7.41E+3nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  7.68E+3nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  8.75E+3nMAssay Description:Inhibition of TTKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331260(3-(7-methoxy-1H-indol-2-yl)-1H-indazole | CHEMBL12...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  2.24E+4nMAssay Description:Inhibition of PKC-thetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331278(3-(7-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLymphokine-activated killer T-cell-originated protein kinase(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PBKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of DAPK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Nycomed

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PKC-beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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