BindingDB logo
myBDB logout

PubMed code 21112785

Compile data set for download or QSAR
Found 151 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM16016
PNG
(CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1
Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

DrugBank
MMDB
PDB
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16016
PNG
(CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1
Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333983
PNG
(4-(8-chloronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Clc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20ClN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334001
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1)C1CCOCC1
Show InChI InChI=1S/C28H31N5O2/c34-28-32(25-11-10-20-6-4-5-7-21(20)18-25)27(31-33(28)24-13-16-35-17-14-24)22-12-15-29-26(19-22)30-23-8-2-1-3-9-23/h4-7,10-12,15,18-19,23-24H,1-3,8-9,13-14,16-17H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334000
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H33N5O2/c35-29-33(20-21-13-16-36-17-14-21)32-28(34(29)26-11-10-22-6-4-5-7-23(22)18-26)24-12-15-30-27(19-24)31-25-8-2-1-3-9-25/h4-7,10-12,15,18-19,21,25H,1-3,8-9,13-14,16-17,20H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333997
PNG
(CHEMBL1644646 | methyl 4-(4-(naphthalen-2-yl)-5-ox...)
Show SMILES COC(=O)N1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H32N6O4/c1-38-29(37)33-14-9-24(10-15-33)35-28(36)34(25-7-6-20-4-2-3-5-21(20)18-25)27(32-35)22-8-13-30-26(19-22)31-23-11-16-39-17-12-23/h2-8,13,18-19,23-24H,9-12,14-17H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334008
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H23N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h4-7,10-15,19H,1-3,8-9H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333980
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H28N6O/c36-29-34(20-21-12-15-30-16-13-21)33-28(35(29)26-11-10-22-6-4-5-7-23(22)18-26)24-14-17-31-27(19-24)32-25-8-2-1-3-9-25/h4-7,10-19,25H,1-3,8-9,20H2,(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333987
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-3-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-10-23-20(13-17)24-18-6-3-11-29-14-18/h1-2,4-5,7-10,12-13,18H,3,6,11,14H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333989
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES FC(F)(F)CN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H31F3N6O2/c30-29(31,32)19-36-13-8-24(9-14-36)38-28(39)37(25-6-5-20-3-1-2-4-21(20)17-25)27(35-38)22-7-12-33-26(18-22)34-23-10-15-40-16-11-23/h1-7,12,17-18,23-24H,8-11,13-16,19H2,(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333982
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)18-9-8-15-5-1-2-6-16(15)13-18)17-10-12-24-20(14-17)25-19-7-3-4-11-23-19/h1-14H,(H,27,29)(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334007
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(t...)
Show SMILES O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C28H26N6O2/c35-28-33(19-24-7-3-4-13-29-24)32-27(34(28)25-9-8-20-5-1-2-6-21(20)17-25)22-10-14-30-26(18-22)31-23-11-15-36-16-12-23/h1-10,13-14,17-18,23H,11-12,15-16,19H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 54n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333998
PNG
(4-(8-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 54n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333997
PNG
(CHEMBL1644646 | methyl 4-(4-(naphthalen-2-yl)-5-ox...)
Show SMILES COC(=O)N1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H32N6O4/c1-38-29(37)33-14-9-24(10-15-33)35-28(36)34(25-7-6-20-4-2-3-5-21(20)18-25)27(32-35)22-8-13-30-26(19-22)31-23-11-16-39-17-12-23/h2-8,13,18-19,23-24H,9-12,14-17H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 58n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334000
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H33N5O2/c35-29-33(20-21-13-16-36-17-14-21)32-28(34(29)26-11-10-22-6-4-5-7-23(22)18-26)24-12-15-30-27(19-24)31-25-8-2-1-3-9-25/h4-7,10-12,15,18-19,21,25H,1-3,8-9,13-14,16-17,20H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334003
PNG
(4-(naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H17N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h1-15H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334008
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H23N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h4-7,10-15,19H,1-3,8-9H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 69n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333992
PNG
(3-(2-(cyclobutylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C21H19N5O/c27-21-25-24-20(16-10-11-22-19(13-16)23-17-6-3-7-17)26(21)18-9-8-14-4-1-2-5-15(14)12-18/h1-2,4-5,8-13,17H,3,6-7H2,(H,22,23)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333990
PNG
(4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333994
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-6-5-15-3-1-2-4-16(15)13-19)17-7-10-23-20(14-17)24-18-8-11-29-12-9-18/h1-7,10,13-14,18H,8-9,11-12H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333996
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCOC1
Show InChI InChI=1S/C26H27N5O3/c32-26-30(22-6-5-18-3-1-2-4-19(18)15-22)25(29-31(26)23-10-14-34-17-23)20-7-11-27-24(16-20)28-21-8-12-33-13-9-21/h1-7,11,15-16,21,23H,8-10,12-14,17H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 92n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334007
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(t...)
Show SMILES O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C28H26N6O2/c35-28-33(19-24-7-3-4-13-29-24)32-27(34(28)25-9-8-20-5-1-2-6-21(20)17-25)22-10-14-30-26(18-22)31-23-11-15-36-16-12-23/h1-10,13-14,17-18,23H,11-12,15-16,19H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 93n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334004
PNG
(4-(8-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 94n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333980
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H28N6O/c36-29-34(20-21-12-15-30-16-13-21)33-28(35(29)26-11-10-22-6-4-5-7-23(22)18-26)24-14-17-31-27(19-24)32-25-8-2-1-3-9-25/h4-7,10-19,25H,1-3,8-9,20H2,(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 97n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334001
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1)C1CCOCC1
Show InChI InChI=1S/C28H31N5O2/c34-28-32(25-11-10-20-6-4-5-7-21(20)18-25)27(31-33(28)24-13-16-35-17-14-24)22-12-15-29-26(19-22)30-23-8-2-1-3-9-23/h4-7,10-12,15,18-19,23-24H,1-3,8-9,13-14,16-17H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 97n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333981
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahy...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)-c1ccccn1
Show InChI InChI=1S/C27H24N6O2/c34-27-32(23-9-8-19-5-1-2-6-20(19)17-23)26(31-33(27)25-7-3-4-13-29-25)21-10-14-28-24(18-21)30-22-11-15-35-16-12-22/h1-10,13-14,17-18,22H,11-12,15-16H2,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333982
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)18-9-8-15-5-1-2-6-16(15)13-18)17-10-12-24-20(14-17)25-19-7-3-4-11-23-19/h1-14H,(H,27,29)(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333983
PNG
(4-(8-chloronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Clc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20ClN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333984
PNG
(CHEMBL1644630 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)C1CC1
Show InChI InChI=1S/C21H17N5O2/c27-20(14-5-6-14)23-18-12-16(9-10-22-18)19-24-25-21(28)26(19)17-8-7-13-3-1-2-4-15(13)11-17/h1-4,7-12,14H,5-6H2,(H,25,28)(H,22,23,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333985
PNG
(3-(2-(cyclopentylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O/c28-22-26-25-21(17-11-12-23-20(14-17)24-18-7-3-4-8-18)27(22)19-10-9-15-5-1-2-6-16(15)13-19/h1-2,5-6,9-14,18H,3-4,7-8H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333987
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-3-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-10-23-20(13-17)24-18-6-3-11-29-14-18/h1-2,4-5,7-10,12-13,18H,3,6,11,14H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333986
PNG
(3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H17N5O/c26-20-24-23-19(15-9-10-21-18(12-15)22-16-6-7-16)25(20)17-8-5-13-3-1-2-4-14(13)11-17/h1-5,8-12,16H,6-7H2,(H,21,22)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333983
PNG
(4-(8-chloronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Clc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20ClN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333981
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahy...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)-c1ccccn1
Show InChI InChI=1S/C27H24N6O2/c34-27-32(23-9-8-19-5-1-2-6-20(19)17-23)26(31-33(27)25-7-3-4-13-29-25)21-10-14-28-24(18-21)30-22-11-15-35-16-12-22/h1-10,13-14,17-18,22H,11-12,15-16H2,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333988
PNG
(4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetra...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C27H30N6O2/c34-27-32(24-6-5-19-3-1-2-4-20(19)17-24)26(31-33(27)23-8-12-28-13-9-23)21-7-14-29-25(18-21)30-22-10-15-35-16-11-22/h1-7,14,17-18,22-23,28H,8-13,15-16H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333989
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES FC(F)(F)CN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H31F3N6O2/c30-29(31,32)19-36-13-8-24(9-14-36)38-28(39)37(25-6-5-20-3-1-2-4-21(20)17-25)27(35-38)22-7-12-33-26(18-22)34-23-10-15-40-16-11-23/h1-7,12,17-18,23-24H,8-11,13-16,19H2,(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333990
PNG
(4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333991
PNG
(4-(naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3nccs3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H14N6OS/c27-20-25-24-18(15-7-8-21-17(12-15)23-19-22-9-10-28-19)26(20)16-6-5-13-3-1-2-4-14(13)11-16/h1-12H,(H,25,27)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333992
PNG
(3-(2-(cyclobutylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C21H19N5O/c27-21-25-24-20(16-10-11-22-19(13-16)23-17-6-3-7-17)26(21)18-9-8-14-4-1-2-5-15(14)12-18/h1-2,4-5,8-13,17H,3,6-7H2,(H,22,23)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333994
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-6-5-15-3-1-2-4-16(15)13-19)17-7-10-23-20(14-17)24-18-8-11-29-12-9-18/h1-7,10,13-14,18H,8-9,11-12H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333993
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3cccnc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-11-24-20(13-17)25-18-6-3-10-23-14-18/h1-14H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333995
PNG
(1-(1-ethylpiperidin-4-yl)-4-(naphthalen-2-yl)-3-(2...)
Show SMILES CCN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H34N6O2/c1-2-33-15-10-25(11-16-33)35-29(36)34(26-8-7-21-5-3-4-6-22(21)19-26)28(32-35)23-9-14-30-27(20-23)31-24-12-17-37-18-13-24/h3-9,14,19-20,24-25H,2,10-13,15-18H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333996
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCOC1
Show InChI InChI=1S/C26H27N5O3/c32-26-30(22-6-5-18-3-1-2-4-19(18)15-22)25(29-31(26)23-10-14-34-17-23)20-7-11-27-24(16-20)28-21-8-12-33-13-9-21/h1-7,11,15-16,21,23H,8-10,12-14,17H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333985
PNG
(3-(2-(cyclopentylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O/c28-22-26-25-21(17-11-12-23-20(14-17)24-18-7-3-4-8-18)27(22)19-10-9-15-5-1-2-6-16(15)13-19/h1-2,5-6,9-14,18H,3-4,7-8H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333997
PNG
(CHEMBL1644646 | methyl 4-(4-(naphthalen-2-yl)-5-ox...)
Show SMILES COC(=O)N1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H32N6O4/c1-38-29(37)33-14-9-24(10-15-33)35-28(36)34(25-7-6-20-4-2-3-5-21(20)18-25)27(32-35)22-8-13-30-26(19-22)31-23-11-16-39-17-12-23/h2-8,13,18-19,23-24H,9-12,14-17H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333998
PNG
(4-(8-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333986
PNG
(3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H17N5O/c26-20-24-23-19(15-9-10-21-18(12-15)22-16-6-7-16)25(20)17-8-5-13-3-1-2-4-14(13)11-17/h1-5,8-12,16H,6-7H2,(H,21,22)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50333999
PNG
(CHEMBL1644629 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15N5O2/c1-12(25)21-17-11-15(8-9-20-17)18-22-23-19(26)24(18)16-7-6-13-4-2-3-5-14(13)10-16/h2-11H,1H3,(H,23,26)(H,20,21,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 410n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334001
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1)C1CCOCC1
Show InChI InChI=1S/C28H31N5O2/c34-28-32(25-11-10-20-6-4-5-7-21(20)18-25)27(31-33(28)24-13-16-35-17-14-24)22-12-15-29-26(19-22)30-23-8-2-1-3-9-23/h4-7,10-12,15,18-19,23-24H,1-3,8-9,13-14,16-17H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 420n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334000
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H33N5O2/c35-29-33(20-21-13-16-36-17-14-21)32-28(34(29)26-11-10-22-6-4-5-7-23(22)18-26)24-12-15-30-27(19-24)31-25-8-2-1-3-9-25/h4-7,10-12,15,18-19,21,25H,1-3,8-9,13-14,16-17,20H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 420n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334002
PNG
(4-(6-bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Brc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20BrN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333984
PNG
(CHEMBL1644630 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)C1CC1
Show InChI InChI=1S/C21H17N5O2/c27-20(14-5-6-14)23-18-12-16(9-10-22-18)19-24-25-21(28)26(19)17-8-7-13-3-1-2-4-15(13)11-17/h1-4,7-12,14H,5-6H2,(H,25,28)(H,22,23,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334003
PNG
(4-(naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H17N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h1-15H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 470n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333998
PNG
(4-(8-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333988
PNG
(4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetra...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C27H30N6O2/c34-27-32(24-6-5-19-3-1-2-4-20(19)17-24)26(31-33(27)23-8-12-28-13-9-23)21-7-14-29-25(18-21)30-22-10-15-35-16-11-22/h1-7,14,17-18,22-23,28H,8-13,15-16H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 530n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334004
PNG
(4-(8-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 570n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334005
PNG
(CHEMBL1644631 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C24H17N5O2/c30-23(17-7-2-1-3-8-17)26-21-15-19(12-13-25-21)22-27-28-24(31)29(22)20-11-10-16-6-4-5-9-18(16)14-20/h1-15H,(H,28,31)(H,25,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 590n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333991
PNG
(4-(naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3nccs3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H14N6OS/c27-20-25-24-18(15-7-8-21-17(12-15)23-19-22-9-10-28-19)26(20)16-6-5-13-3-1-2-4-14(13)11-16/h1-12H,(H,25,27)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 650n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333980
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H28N6O/c36-29-34(20-21-12-15-30-16-13-21)33-28(35(29)26-11-10-22-6-4-5-7-23(22)18-26)24-14-17-31-27(19-24)32-25-8-2-1-3-9-25/h4-7,10-19,25H,1-3,8-9,20H2,(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333990
PNG
(4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 740n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333987
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-3-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-10-23-20(13-17)24-18-6-3-11-29-14-18/h1-2,4-5,7-10,12-13,18H,3,6,11,14H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 740n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334002
PNG
(4-(6-bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Brc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20BrN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 780n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333989
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES FC(F)(F)CN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H31F3N6O2/c30-29(31,32)19-36-13-8-24(9-14-36)38-28(39)37(25-6-5-20-3-1-2-4-21(20)17-25)27(35-38)22-7-12-33-26(18-22)34-23-10-15-40-16-11-23/h1-7,12,17-18,23-24H,8-11,13-16,19H2,(H,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 900n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334006
PNG
(4-(6-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 950n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333993
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3cccnc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-11-24-20(13-17)25-18-6-3-10-23-14-18/h1-14H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 950n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334007
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(t...)
Show SMILES O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C28H26N6O2/c35-28-33(19-24-7-3-4-13-29-24)32-27(34(28)25-9-8-20-5-1-2-6-21(20)17-25)22-10-14-30-26(18-22)31-23-11-15-36-16-12-23/h1-10,13-14,17-18,23H,11-12,15-16,19H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 990n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334008
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H23N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h4-7,10-15,19H,1-3,8-9H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333981
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahy...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)-c1ccccn1
Show InChI InChI=1S/C27H24N6O2/c34-27-32(23-9-8-19-5-1-2-6-20(19)17-23)26(31-33(27)25-7-3-4-13-29-25)21-10-14-28-24(18-21)30-22-11-15-35-16-12-22/h1-10,13-14,17-18,22H,11-12,15-16H2,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333999
PNG
(CHEMBL1644629 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15N5O2/c1-12(25)21-17-11-15(8-9-20-17)18-22-23-19(26)24(18)16-7-6-13-4-2-3-5-14(13)10-16/h2-11H,1H3,(H,23,26)(H,20,21,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334006
PNG
(4-(6-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333994
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-6-5-15-3-1-2-4-16(15)13-19)17-7-10-23-20(14-17)24-18-8-11-29-12-9-18/h1-7,10,13-14,18H,8-9,11-12H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333992
PNG
(3-(2-(cyclobutylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C21H19N5O/c27-21-25-24-20(16-10-11-22-19(13-16)23-17-6-3-7-17)26(21)18-9-8-14-4-1-2-5-15(14)12-18/h1-2,4-5,8-13,17H,3,6-7H2,(H,22,23)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50333995
PNG
(1-(1-ethylpiperidin-4-yl)-4-(naphthalen-2-yl)-3-(2...)
Show SMILES CCN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H34N6O2/c1-2-33-15-10-25(11-16-33)35-29(36)34(26-8-7-21-5-3-4-6-22(21)19-26)28(32-35)23-9-14-30-27(20-23)31-24-12-17-37-18-13-24/h3-9,14,19-20,24-25H,2,10-13,15-18H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333982
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)18-9-8-15-5-1-2-6-16(15)13-18)17-10-12-24-20(14-17)25-19-7-3-4-11-23-19/h1-14H,(H,27,29)(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334004
PNG
(4-(8-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333993
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3cccnc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-11-24-20(13-17)25-18-6-3-10-23-14-18/h1-14H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333996
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCOC1
Show InChI InChI=1S/C26H27N5O3/c32-26-30(22-6-5-18-3-1-2-4-19(18)15-22)25(29-31(26)23-10-14-34-17-23)20-7-11-27-24(16-20)28-21-8-12-33-13-9-21/h1-7,11,15-16,21,23H,8-10,12-14,17H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.80E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333986
PNG
(3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H17N5O/c26-20-24-23-19(15-9-10-21-18(12-15)22-16-6-7-16)25(20)17-8-5-13-3-1-2-4-14(13)11-17/h1-5,8-12,16H,6-7H2,(H,21,22)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334010
PNG
((S)-4-(naphthalen-2-yl)-3-(2-(1-phenylethylamino)p...)
Show SMILES C[C@H](Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C25H21N5O/c1-17(18-7-3-2-4-8-18)27-23-16-21(13-14-26-23)24-28-29-25(31)30(24)22-12-11-19-9-5-6-10-20(19)15-22/h2-17H,1H3,(H,26,27)(H,29,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334002
PNG
(4-(6-bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Brc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20BrN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334005
PNG
(CHEMBL1644631 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C24H17N5O2/c30-23(17-7-2-1-3-8-17)26-21-15-19(12-13-25-21)22-27-28-24(31)29(22)20-11-10-16-6-4-5-9-18(16)14-20/h1-15H,(H,28,31)(H,25,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.40E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333988
PNG
(4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetra...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C27H30N6O2/c34-27-32(24-6-5-19-3-1-2-4-20(19)17-24)26(31-33(27)23-8-12-28-13-9-23)21-7-14-29-25(18-21)30-22-10-15-35-16-11-22/h1-7,14,17-18,22-23,28H,8-13,15-16H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333984
PNG
(CHEMBL1644630 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)C1CC1
Show InChI InChI=1S/C21H17N5O2/c27-20(14-5-6-14)23-18-12-16(9-10-22-18)19-24-25-21(28)26(19)17-8-7-13-3-1-2-4-15(13)11-17/h1-4,7-12,14H,5-6H2,(H,25,28)(H,22,23,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.60E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334010
PNG
((S)-4-(naphthalen-2-yl)-3-(2-(1-phenylethylamino)p...)
Show SMILES C[C@H](Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C25H21N5O/c1-17(18-7-3-2-4-8-18)27-23-16-21(13-14-26-23)24-28-29-25(31)30(24)22-12-11-19-9-5-6-10-20(19)15-22/h2-17H,1H3,(H,26,27)(H,29,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334010
PNG
((S)-4-(naphthalen-2-yl)-3-(2-(1-phenylethylamino)p...)
Show SMILES C[C@H](Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C25H21N5O/c1-17(18-7-3-2-4-8-18)27-23-16-21(13-14-26-23)24-28-29-25(31)30(24)22-12-11-19-9-5-6-10-20(19)15-22/h2-17H,1H3,(H,26,27)(H,29,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333995
PNG
(1-(1-ethylpiperidin-4-yl)-4-(naphthalen-2-yl)-3-(2...)
Show SMILES CCN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H34N6O2/c1-2-33-15-10-25(11-16-33)35-29(36)34(26-8-7-21-5-3-4-6-22(21)19-26)28(32-35)23-9-14-30-27(20-23)31-24-12-17-37-18-13-24/h3-9,14,19-20,24-25H,2,10-13,15-18H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334010
PNG
((S)-4-(naphthalen-2-yl)-3-(2-(1-phenylethylamino)p...)
Show SMILES C[C@H](Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C25H21N5O/c1-17(18-7-3-2-4-8-18)27-23-16-21(13-14-26-23)24-28-29-25(31)30(24)22-12-11-19-9-5-6-10-20(19)15-22/h2-17H,1H3,(H,26,27)(H,29,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333997
PNG
(CHEMBL1644646 | methyl 4-(4-(naphthalen-2-yl)-5-ox...)
Show SMILES COC(=O)N1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H32N6O4/c1-38-29(37)33-14-9-24(10-15-33)35-28(36)34(25-7-6-20-4-2-3-5-21(20)18-25)27(32-35)22-8-13-30-26(19-22)31-23-11-16-39-17-12-23/h2-8,13,18-19,23-24H,9-12,14-17H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334010
PNG
((S)-4-(naphthalen-2-yl)-3-(2-(1-phenylethylamino)p...)
Show SMILES C[C@H](Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C25H21N5O/c1-17(18-7-3-2-4-8-18)27-23-16-21(13-14-26-23)24-28-29-25(31)30(24)22-12-11-19-9-5-6-10-20(19)15-22/h2-17H,1H3,(H,26,27)(H,29,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333988
PNG
(4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetra...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C27H30N6O2/c34-27-32(24-6-5-19-3-1-2-4-20(19)17-24)26(31-33(27)23-8-12-28-13-9-23)21-7-14-29-25(18-21)30-22-10-15-35-16-11-22/h1-7,14,17-18,22-23,28H,8-13,15-16H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334006
PNG
(4-(6-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.30E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334003
PNG
(4-(naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H17N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h1-15H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.70E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333999
PNG
(CHEMBL1644629 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15N5O2/c1-12(25)21-17-11-15(8-9-20-17)18-22-23-19(26)24(18)16-7-6-13-4-2-3-5-14(13)10-16/h2-11H,1H3,(H,23,26)(H,20,21,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333993
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3cccnc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-11-24-20(13-17)25-18-6-3-10-23-14-18/h1-14H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50334009
PNG
(4-(naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-tria...)
Show SMILES O=c1[nH]nc(-c2ccncc2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12N4O/c22-17-20-19-16(13-7-9-18-10-8-13)21(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK3 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333987
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-3-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-10-23-20(13-17)24-18-6-3-11-29-14-18/h1-2,4-5,7-10,12-13,18H,3,6,11,14H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50334009
PNG
(4-(naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-tria...)
Show SMILES O=c1[nH]nc(-c2ccncc2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12N4O/c22-17-20-19-16(13-7-9-18-10-8-13)21(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333991
PNG
(4-(naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3nccs3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H14N6OS/c27-20-25-24-18(15-7-8-21-17(12-15)23-19-22-9-10-28-19)26(20)16-6-5-13-3-1-2-4-14(13)11-16/h1-12H,(H,25,27)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334006
PNG
(4-(6-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334007
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(t...)
Show SMILES O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C28H26N6O2/c35-28-33(19-24-7-3-4-13-29-24)32-27(34(28)25-9-8-20-5-1-2-6-21(20)17-25)22-10-14-30-26(18-22)31-23-11-15-36-16-12-23/h1-10,13-14,17-18,23H,11-12,15-16,19H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334009
PNG
(4-(naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-tria...)
Show SMILES O=c1[nH]nc(-c2ccncc2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12N4O/c22-17-20-19-16(13-7-9-18-10-8-13)21(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333991
PNG
(4-(naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3nccs3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H14N6OS/c27-20-25-24-18(15-7-8-21-17(12-15)23-19-22-9-10-28-19)26(20)16-6-5-13-3-1-2-4-14(13)11-16/h1-12H,(H,25,27)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333994
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-6-5-15-3-1-2-4-16(15)13-19)17-7-10-23-20(14-17)24-18-8-11-29-12-9-18/h1-7,10,13-14,18H,8-9,11-12H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333999
PNG
(CHEMBL1644629 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15N5O2/c1-12(25)21-17-11-15(8-9-20-17)18-22-23-19(26)24(18)16-7-6-13-4-2-3-5-14(13)10-16/h2-11H,1H3,(H,23,26)(H,20,21,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334008
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H23N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h4-7,10-15,19H,1-3,8-9H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333985
PNG
(3-(2-(cyclopentylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O/c28-22-26-25-21(17-11-12-23-20(14-17)24-18-7-3-4-8-18)27(22)19-10-9-15-5-1-2-6-16(15)13-19/h1-2,5-6,9-14,18H,3-4,7-8H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333993
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3cccnc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-11-24-20(13-17)25-18-6-3-10-23-14-18/h1-14H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333981
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahy...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)-c1ccccn1
Show InChI InChI=1S/C27H24N6O2/c34-27-32(23-9-8-19-5-1-2-6-20(19)17-23)26(31-33(27)25-7-3-4-13-29-25)21-10-14-28-24(18-21)30-22-11-15-35-16-12-22/h1-10,13-14,17-18,22H,11-12,15-16H2,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333992
PNG
(3-(2-(cyclobutylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C21H19N5O/c27-21-25-24-20(16-10-11-22-19(13-16)23-17-6-3-7-17)26(21)18-9-8-14-4-1-2-5-15(14)12-18/h1-2,4-5,8-13,17H,3,6-7H2,(H,22,23)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334002
PNG
(4-(6-bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Brc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20BrN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333987
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-3-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-10-23-20(13-17)24-18-6-3-11-29-14-18/h1-2,4-5,7-10,12-13,18H,3,6,11,14H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334001
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1)C1CCOCC1
Show InChI InChI=1S/C28H31N5O2/c34-28-32(25-11-10-20-6-4-5-7-21(20)18-25)27(31-33(28)24-13-16-35-17-14-24)22-12-15-29-26(19-22)30-23-8-2-1-3-9-23/h4-7,10-12,15,18-19,23-24H,1-3,8-9,13-14,16-17H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333980
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H28N6O/c36-29-34(20-21-12-15-30-16-13-21)33-28(35(29)26-11-10-22-6-4-5-7-23(22)18-26)24-14-17-31-27(19-24)32-25-8-2-1-3-9-25/h4-7,10-19,25H,1-3,8-9,20H2,(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334009
PNG
(4-(naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-tria...)
Show SMILES O=c1[nH]nc(-c2ccncc2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12N4O/c22-17-20-19-16(13-7-9-18-10-8-13)21(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50334005
PNG
(CHEMBL1644631 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C24H17N5O2/c30-23(17-7-2-1-3-8-17)26-21-15-19(12-13-25-21)22-27-28-24(31)29(22)20-11-10-16-6-4-5-9-18(16)14-20/h1-15H,(H,28,31)(H,25,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334008
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H23N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h4-7,10-15,19H,1-3,8-9H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333990
PNG
(4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334004
PNG
(4-(8-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333998
PNG
(4-(8-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333996
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCOC1
Show InChI InChI=1S/C26H27N5O3/c32-26-30(22-6-5-18-3-1-2-4-19(18)15-22)25(29-31(26)23-10-14-34-17-23)20-7-11-27-24(16-20)28-21-8-12-33-13-9-21/h1-7,11,15-16,21,23H,8-10,12-14,17H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334004
PNG
(4-(8-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333988
PNG
(4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetra...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C27H30N6O2/c34-27-32(24-6-5-19-3-1-2-4-20(19)17-24)26(31-33(27)23-8-12-28-13-9-23)21-7-14-29-25(18-21)30-22-10-15-35-16-11-22/h1-7,14,17-18,22-23,28H,8-13,15-16H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334005
PNG
(CHEMBL1644631 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C24H17N5O2/c30-23(17-7-2-1-3-8-17)26-21-15-19(12-13-25-21)22-27-28-24(31)29(22)20-11-10-16-6-4-5-9-18(16)14-20/h1-15H,(H,28,31)(H,25,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334006
PNG
(4-(6-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Nc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H22N6O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10,23H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333998
PNG
(4-(8-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333981
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahy...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)-c1ccccn1
Show InChI InChI=1S/C27H24N6O2/c34-27-32(23-9-8-19-5-1-2-6-20(19)17-23)26(31-33(27)25-7-3-4-13-29-25)21-10-14-28-24(18-21)30-22-11-15-35-16-12-22/h1-10,13-14,17-18,22H,11-12,15-16H2,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333986
PNG
(3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H17N5O/c26-20-24-23-19(15-9-10-21-18(12-15)22-16-6-7-16)25(20)17-8-5-13-3-1-2-4-14(13)11-17/h1-5,8-12,16H,6-7H2,(H,21,22)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333990
PNG
(4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-py...)
Show SMILES Fc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20FN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333986
PNG
(3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H17N5O/c26-20-24-23-19(15-9-10-21-18(12-15)22-16-6-7-16)25(20)17-8-5-13-3-1-2-4-14(13)11-17/h1-5,8-12,16H,6-7H2,(H,21,22)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334003
PNG
(4-(naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H17N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h1-15H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333984
PNG
(CHEMBL1644630 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)C1CC1
Show InChI InChI=1S/C21H17N5O2/c27-20(14-5-6-14)23-18-12-16(9-10-22-18)19-24-25-21(28)26(19)17-8-7-13-3-1-2-4-15(13)11-17/h1-4,7-12,14H,5-6H2,(H,25,28)(H,22,23,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334007
PNG
(4-(naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(t...)
Show SMILES O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C28H26N6O2/c35-28-33(19-24-7-3-4-13-29-24)32-27(34(28)25-9-8-20-5-1-2-6-21(20)17-25)22-10-14-30-26(18-22)31-23-11-15-36-16-12-23/h1-10,13-14,17-18,23H,11-12,15-16,19H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333994
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-6-5-15-3-1-2-4-16(15)13-19)17-7-10-23-20(14-17)24-18-8-11-29-12-9-18/h1-7,10,13-14,18H,8-9,11-12H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333992
PNG
(3-(2-(cyclobutylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C21H19N5O/c27-21-25-24-20(16-10-11-22-19(13-16)23-17-6-3-7-17)26(21)18-9-8-14-4-1-2-5-15(14)12-18/h1-2,4-5,8-13,17H,3,6-7H2,(H,22,23)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334005
PNG
(CHEMBL1644631 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C24H17N5O2/c30-23(17-7-2-1-3-8-17)26-21-15-19(12-13-25-21)22-27-28-24(31)29(22)20-11-10-16-6-4-5-9-18(16)14-20/h1-15H,(H,28,31)(H,25,26,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334002
PNG
(4-(6-bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyr...)
Show SMILES Brc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1
Show InChI InChI=1S/C22H20BrN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334000
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H33N5O2/c35-29-33(20-21-13-16-36-17-14-21)32-28(34(29)26-11-10-22-6-4-5-7-23(22)18-26)24-12-15-30-27(19-24)31-25-8-2-1-3-9-25/h4-7,10-12,15,18-19,21,25H,1-3,8-9,13-14,16-17,20H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333997
PNG
(CHEMBL1644646 | methyl 4-(4-(naphthalen-2-yl)-5-ox...)
Show SMILES COC(=O)N1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O
Show InChI InChI=1S/C29H32N6O4/c1-38-29(37)33-14-9-24(10-15-33)35-28(36)34(25-7-6-20-4-2-3-5-21(20)18-25)27(32-35)22-8-13-30-26(19-22)31-23-11-16-39-17-12-23/h2-8,13,18-19,23-24H,9-12,14-17H2,1H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334009
PNG
(4-(naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-tria...)
Show SMILES O=c1[nH]nc(-c2ccncc2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12N4O/c22-17-20-19-16(13-7-9-18-10-8-13)21(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333985
PNG
(3-(2-(cyclopentylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O/c28-22-26-25-21(17-11-12-23-20(14-17)24-18-7-3-4-8-18)27(22)19-10-9-15-5-1-2-6-16(15)13-19/h1-2,5-6,9-14,18H,3-4,7-8H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333982
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)18-9-8-15-5-1-2-6-16(15)13-18)17-10-12-24-20(14-17)25-19-7-3-4-11-23-19/h1-14H,(H,27,29)(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334000
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H33N5O2/c35-29-33(20-21-13-16-36-17-14-21)32-28(34(29)26-11-10-22-6-4-5-7-23(22)18-26)24-12-15-30-27(19-24)31-25-8-2-1-3-9-25/h4-7,10-12,15,18-19,21,25H,1-3,8-9,13-14,16-17,20H2,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50334001
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1)C1CCOCC1
Show InChI InChI=1S/C28H31N5O2/c34-28-32(25-11-10-20-6-4-5-7-21(20)18-25)27(31-33(28)24-13-16-35-17-14-24)22-12-15-29-26(19-22)30-23-8-2-1-3-9-23/h4-7,10-12,15,18-19,23-24H,1-3,8-9,13-14,16-17H2,(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333980
PNG
(3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-...)
Show SMILES O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C29H28N6O/c36-29-34(20-21-12-15-30-16-13-21)33-28(35(29)26-11-10-22-6-4-5-7-23(22)18-26)24-14-17-31-27(19-24)32-25-8-2-1-3-9-25/h4-7,10-19,25H,1-3,8-9,20H2,(H,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50334003
PNG
(4-(naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H17N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h1-15H,(H,24,25)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333999
PNG
(CHEMBL1644629 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15N5O2/c1-12(25)21-17-11-15(8-9-20-17)18-22-23-19(26)24(18)16-7-6-13-4-2-3-5-14(13)10-16/h2-11H,1H3,(H,23,26)(H,20,21,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333982
PNG
(4-(naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)18-9-8-15-5-1-2-6-16(15)13-18)17-10-12-24-20(14-17)25-19-7-3-4-11-23-19/h1-14H,(H,27,29)(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333996
PNG
(4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-yl...)
Show SMILES O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCOC1
Show InChI InChI=1S/C26H27N5O3/c32-26-30(22-6-5-18-3-1-2-4-19(18)15-22)25(29-31(26)23-10-14-34-17-23)20-7-11-27-24(16-20)28-21-8-12-33-13-9-21/h1-7,11,15-16,21,23H,8-10,12-14,17H2,(H,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50333991
PNG
(4-(naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridi...)
Show SMILES O=c1[nH]nc(-c2ccnc(Nc3nccs3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H14N6OS/c27-20-25-24-18(15-7-8-21-17(12-15)23-19-22-9-10-28-19)26(20)16-6-5-13-3-1-2-4-14(13)11-16/h1-12H,(H,25,27)(H,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant ERK2 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50333985
PNG
(3-(2-(cyclopentylamino)pyridin-4-yl)-4-(naphthalen...)
Show SMILES O=c1[nH]nc(-c2ccnc(NC3CCCC3)c2)n1-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H21N5O/c28-22-26-25-21(17-11-12-23-20(14-17)24-18-7-3-4-8-18)27(22)19-10-9-15-5-1-2-6-16(15)13-19/h1-2,5-6,9-14,18H,3-4,7-8H2,(H,23,24)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant JNK1 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50333984
PNG
(CHEMBL1644630 | N-(4-(4-(naphthalen-2-yl)-5-oxo-4,...)
Show SMILES O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)C1CC1
Show InChI InChI=1S/C21H17N5O2/c27-20(14-5-6-14)23-18-12-16(9-10-22-18)19-24-25-21(28)26(19)17-8-7-13-3-1-2-4-15(13)11-17/h1-4,7-12,14H,5-6H2,(H,25,28)(H,22,23,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of recombinant p38alpha after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 21: 315-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.11.010
BindingDB Entry DOI: 10.7270/Q24F1R0T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%