Compile Data Set for Download or QSAR
maximum 50k data
Found 37 Enz. Inhib. hit(s) with all data for entry = 50033105
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  80nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  80nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at CCR2 in human PBMC cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339630(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-isopropox...)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  1.40E+3nMAssay Description:Antagonist activity at CCR2 in mouse spleen cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339628(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3,4-dichlor...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339629(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-(trifluor...)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339627(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophe...)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50:  2.90E+3nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL4-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339626(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chloro-4-...)
Affinity DataIC50:  3.90E+3nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339634(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR1 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR1 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339639(1-(Benzo[d][1,3]dioxol-5-yl)-3-(3-chlorobenzoyl)ur...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339631(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-phenylphe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR1 in human PBMC cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR3 in human PBMC cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR5 in human PBMC cells assessed as inhibition of CCL5-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR1 in eosinophil cells assessed as inhibition of CCL11-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR3 in eosinophil cells assessed as inhibition of CCL11-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR4 in transfected in THP-1 cells assessed as inhibition of CCL17-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR4 in transfected in THP-1 cells assessed as inhibition of CCL17-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CXCR1 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CXCR1 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339635(1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CXCR2 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CXCR2 in human PMN cells assessed as inhibition of CXCL8-induced chemotaxis after 2 hrs trans-well migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339633(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339632(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(4-phenylphe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Rattus norvegicus)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  1.00E+4nMAssay Description:Antagonist activity at CCR2 in rat spleen cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339637(1-(Benzo[d][1,3]dioxole-6-carbonyl)-3-(3-chlorophe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Telik

Curated by ChEMBL
LigandPNGBDBM50339638(5-(Benzo[d][1,3]dioxol-5-yl)-N-(3,4-dichlorophenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Telik

Curated by ChEMBL
LigandPNGBDBM50339636(1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-d...)
Affinity DataIC50:  1.20E+4nMAssay Description:Antagonist activity at CCR2 in mouse spleen cells assessed as inhibition of CCL2-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed