Compile Data Set for Download or QSAR
maximum 50k data
Found 24 Enz. Inhib. hit(s) with all data for entry = 50033208
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  1.87E+3nMAssay Description:Transcriptional activation of human ERalpha receptor transfected in human U2OS cells assessed as increase of luciferase activity by estrogen response...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50323701(2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341434(CHEMBL1766978 | tert-Butyl-6-hydroxy-3,4-dihydro-2...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341435(2-(Phenylsulfonyl)-1,2,3,4-tetrahydro-6-isoquinoli...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341436(2-(1-Naphthylsulfonyl)-1,2,3,4-tetrahydro-7-isoqui...)
Affinity DataEC50:  3.00E+4nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341437(2-(1-Naphthylsulfonyl)-1,2,3,4-tetrahydro-6-isoqui...)
Affinity DataEC50:  6.00E+4nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341438(2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-6...)
Affinity DataEC50:  2.00E+4nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341439(2,2,2-Trichloro-1-(6-hydroxy-3,4-dihydroisoquinoli...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341440(2-Chloro-2,2-difluoro-1-(6-hydroxy-3,4-dihydroisoq...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341441(2,2,2-Trifluoro-1-(7-hydroxy-3,4-dihydroisoquinoli...)
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341442(2,2,2-Trifluoro-1-(6-methoxy-3,4-dihydroisoquinoli...)
Affinity DataEC50:  2.27E+5nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50323701(2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human N-terminal His6-tagged ERbeta receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide r...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341436(2-(1-Naphthylsulfonyl)-1,2,3,4-tetrahydro-7-isoqui...)
Affinity DataEC50:  6.00E+5nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341437(2-(1-Naphthylsulfonyl)-1,2,3,4-tetrahydro-6-isoqui...)
Affinity DataEC50:  7.00E+5nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341438(2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-6...)
Affinity DataEC50:  1.70E+5nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341439(2,2,2-Trichloro-1-(6-hydroxy-3,4-dihydroisoquinoli...)
Affinity DataEC50:  6.20E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341440(2-Chloro-2,2-difluoro-1-(6-hydroxy-3,4-dihydroisoq...)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341441(2,2,2-Trifluoro-1-(7-hydroxy-3,4-dihydroisoquinoli...)
Affinity DataEC50:  2.00E+4nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341442(2,2,2-Trifluoro-1-(6-methoxy-3,4-dihydroisoquinoli...)
Affinity DataEC50:  3.40E+5nMAssay Description:Agonist activity at human N-terminal His6-tagged ERalpha receptor LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of SRC1 peptide ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50341433(2-(trifluoromethylsulfonyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataEC50:  310nMAssay Description:Transcriptional activation of human ERbeta receptor transfected in human U2OS cells assessed as increase of luciferase activity by estrogen response ...More data for this Ligand-Target Pair