Compile Data Set for Download or QSAR
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Found 12 Enz. Inhib. hit(s) with all data for entry = 50033218
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM46106(6-hydroxy-4-keto-N-phenyl-2-thioxo-1H-pyrimidine-5...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341545((E)-N-Methyl-2-(pyridin-2-ylmethylene)hydrazinecar...)
Affinity DataIC50:  7.60E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341550((E)-N-Ethyl-2-(1-(pyridin-2-yl)ethylidene)hydrazin...)
Affinity DataIC50:  7.90E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341549((E)-N-Methyl-2-(1-(pyridin-2-yl)ethylidene)hydrazi...)
Affinity DataIC50:  9.20E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341546((E)-N-Ethyl-2-(pyridin-2-ylmethylene)hydrazinecarb...)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341547((E)-N-Isopropyl-2-(pyridin-2-ylmethylene)hydrazine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341553((E)-2-(Pyridin-2-ylmethylene)hydrazinecarbothioami...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM57228(1-allyl-3-[1-(2-pyridyl)ethylideneamino]thiourea |...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341555((E)-N-Methyl-2-(1-(pyrazin-2-yl)ethylidene)hydrazi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341551((E)-N'-(Pyridin-2-ylmethylene)pyrrolidine-1-carbot...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341548((E)-N-Allyl-2-(pyridin-2-ylmethylene)hydrazinecarb...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50341552((E)-N-Benzyl-2-(pyridin-2-ylmethylene)hydrazinecar...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed