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Found 6 Enz. Inhib. hit(s) with all data for entry = 50034468
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Shanghai Haini Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362901(CHEMBL1945285)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Shanghai Haini Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50169047((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Affinity DataIC50:  99nMAssay Description:Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured af...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Shanghai Haini Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362901(CHEMBL1945285)
Affinity DataIC50:  500nMAssay Description:Inhibition of ovine COX1 by EIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Shanghai Haini Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50362901(CHEMBL1945285)
Affinity DataIC50:  530nMAssay Description:Inhibition of COX2 in LPS-stimulated and PMA-treated human U937 cells assessed as PGE2 production after 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Shanghai Haini Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50169047((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Affinity DataIC50:  730nMAssay Description:Inhibition of COX2 in LPS-stimulated and PMA-treated human U937 cells assessed as PGE2 production after 15 mins by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Shanghai Haini Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50169047((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of ovine COX1 by EIAMore data for this Ligand-Target Pair