Found 83 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prothrombin
(Homo sapiens (Human)) | BDBM50349355
(CHEMBL1809213)Show SMILES NC(N)=NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C27H38N8O4S/c28-24(29)21-13-11-19(12-14-21)17-33-25(36)23-10-6-16-35(23)26(37)22(9-4-5-15-32-27(30)31)34-40(38,39)18-20-7-2-1-3-8-20/h1-3,7-8,11-14,22-23,34H,4-6,9-10,15-18H2,(H3,28,29)(H,33,36)(H4,30,31,32)/t22-,23+/m1/s1 | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349358
(CHEMBL1809216)Show SMILES NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N6O4S/c27-15-5-4-9-22(31-37(35,36)18-20-7-2-1-3-8-20)26(34)32-16-6-10-23(32)25(33)30-17-19-11-13-21(14-12-19)24(28)29/h1-3,7-8,11-14,22-23,31H,4-6,9-10,15-18,27H2,(H3,28,29)(H,30,33)/t22-,23+/m1/s1 | PDB
Reactome pathway
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PC cid
PC sid
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| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349348
(CHEMBL1809254)Show SMILES C[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C23H33N7O3S/c1-16(29-14-17-9-11-19(12-10-17)22(24)25)21(31)20(8-5-13-28-23(26)27)30-34(32,33)15-18-6-3-2-4-7-18/h2-4,6-7,9-12,16,20,29-30H,5,8,13-15H2,1H3,(H3,24,25)(H4,26,27,28)/t16-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
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PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349344
(CHEMBL1809250)Show SMILES CCC(NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H35N7O3S/c1-2-20(30-15-17-10-12-19(13-11-17)23(25)26)22(32)21(9-6-14-29-24(27)28)31-35(33,34)16-18-7-4-3-5-8-18/h3-5,7-8,10-13,20-21,30-31H,2,6,9,14-16H2,1H3,(H3,25,26)(H4,27,28,29)/t20?,21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC sid
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PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC cid
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| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349355
(CHEMBL1809213)Show SMILES NC(N)=NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C27H38N8O4S/c28-24(29)21-13-11-19(12-14-21)17-33-25(36)23-10-6-16-35(23)26(37)22(9-4-5-15-32-27(30)31)34-40(38,39)18-20-7-2-1-3-8-20/h1-3,7-8,11-14,22-23,34H,4-6,9-10,15-18H2,(H3,28,29)(H,33,36)(H4,30,31,32)/t22-,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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| CHEMBL
PC cid
PC sid
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| Article
PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | PDB
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Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Prothrombin
(Homo sapiens (Human)) | BDBM50349333
(CHEMBL1809238)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)c2ncccn2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C33H41N9O5S/c34-30(35)26-11-9-24(10-12-26)22-38-31(44)28-8-4-17-42(28)32(45)27(39-48(46,47)23-25-6-2-1-3-7-25)13-14-29(43)40-18-20-41(21-19-40)33-36-15-5-16-37-33/h1-3,5-7,9-12,15-16,27-28,39H,4,8,13-14,17-23H2,(H3,34,35)(H,38,44)/t27-,28+/m1/s1 | PDB
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| 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349357
(CHEMBL1809214)Show SMILES CC(C)(C)OC(=O)CC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C29H39N5O6S/c1-29(2,3)40-25(35)16-15-23(33-41(38,39)19-21-8-5-4-6-9-21)28(37)34-17-7-10-24(34)27(36)32-18-20-11-13-22(14-12-20)26(30)31/h4-6,8-9,11-14,23-24,33H,7,10,15-19H2,1-3H3,(H3,30,31)(H,32,36)/t23-,24+/m1/s1 | PDB
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| Article
PubMed
| 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | PDB
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| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasma kallikrein |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349334
(CHEMBL1809239)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)C(=O)OCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C37H45N7O7S/c38-34(39)30-15-13-27(14-16-30)24-40-35(46)32-12-7-19-44(32)36(47)31(41-52(49,50)26-29-10-5-2-6-11-29)17-18-33(45)42-20-22-43(23-21-42)37(48)51-25-28-8-3-1-4-9-28/h1-6,8-11,13-16,31-32,41H,7,12,17-26H2,(H3,38,39)(H,40,46)/t31-,32+/m1/s1 | PDB
Reactome pathway
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PC sid
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| Article
PubMed
| 9.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349355
(CHEMBL1809213)Show SMILES NC(N)=NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C27H38N8O4S/c28-24(29)21-13-11-19(12-14-21)17-33-25(36)23-10-6-16-35(23)26(37)22(9-4-5-15-32-27(30)31)34-40(38,39)18-20-7-2-1-3-8-20/h1-3,7-8,11-14,22-23,34H,4-6,9-10,15-18H2,(H3,28,29)(H,33,36)(H4,30,31,32)/t22-,23+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349336
(CHEMBL1809241)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C29H39N7O5S/c30-27(31)23-10-8-21(9-11-23)19-33-28(38)25-7-4-16-36(25)29(39)24(12-13-26(37)35-17-14-32-15-18-35)34-42(40,41)20-22-5-2-1-3-6-22/h1-3,5-6,8-11,24-25,32,34H,4,7,12-20H2,(H3,30,31)(H,33,38)/t24-,25+/m1/s1 | PDB
Reactome pathway
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| 13.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349344
(CHEMBL1809250)Show SMILES CCC(NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H35N7O3S/c1-2-20(30-15-17-10-12-19(13-11-17)23(25)26)22(32)21(9-6-14-29-24(27)28)31-35(33,34)16-18-7-4-3-5-8-18/h3-5,7-8,10-13,20-21,30-31H,2,6,9,14-16H2,1H3,(H3,25,26)(H4,27,28,29)/t20?,21-/m1/s1 | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
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Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349350
(CHEMBL1809256)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](CO)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C23H33N7O4S/c24-22(25)18-10-8-16(9-11-18)13-29-20(14-31)21(32)19(7-4-12-28-23(26)27)30-35(33,34)15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19-20,29-31H,4,7,12-15H2,(H3,24,25)(H4,26,27,28)/t19-,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC sid
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Similars
| Article
PubMed
| 14.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349345
(CHEMBL1809251)Show SMILES CCC[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-2-7-21(31-16-18-11-13-20(14-12-18)24(26)27)23(33)22(10-6-15-30-25(28)29)32-36(34,35)17-19-8-4-3-5-9-19/h3-5,8-9,11-14,21-22,31-32H,2,6-7,10,15-17H2,1H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m0/s1 | KEGG
UniProtKB/SwissProt
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Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349333
(CHEMBL1809238)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)c2ncccn2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C33H41N9O5S/c34-30(35)26-11-9-24(10-12-26)22-38-31(44)28-8-4-17-42(28)32(45)27(39-48(46,47)23-25-6-2-1-3-7-25)13-14-29(43)40-18-20-41(21-19-40)33-36-15-5-16-37-33/h1-3,5-7,9-12,15-16,27-28,39H,4,8,13-14,17-23H2,(H3,34,35)(H,38,44)/t27-,28+/m1/s1 | KEGG
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UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349355
(CHEMBL1809213)Show SMILES NC(N)=NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C27H38N8O4S/c28-24(29)21-13-11-19(12-14-21)17-33-25(36)23-10-6-16-35(23)26(37)22(9-4-5-15-32-27(30)31)34-40(38,39)18-20-7-2-1-3-8-20/h1-3,7-8,11-14,22-23,34H,4-6,9-10,15-18H2,(H3,28,29)(H,33,36)(H4,30,31,32)/t22-,23+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 2
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349346
(CHEMBL1809252)Show SMILES CC(C)[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-17(2)22(31-15-18-10-12-20(13-11-18)24(26)27)23(33)21(9-6-14-30-25(28)29)32-36(34,35)16-19-7-4-3-5-8-19/h3-5,7-8,10-13,17,21-22,31-32H,6,9,14-16H2,1-2H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349346
(CHEMBL1809252)Show SMILES CC(C)[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-17(2)22(31-15-18-10-12-20(13-11-18)24(26)27)23(33)21(9-6-14-30-25(28)29)32-36(34,35)16-19-7-4-3-5-8-19/h3-5,7-8,10-13,17,21-22,31-32H,6,9,14-16H2,1-2H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349347
(CHEMBL1809253)Show SMILES CC[C@H](C)[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H39N7O3S/c1-3-18(2)23(32-16-19-11-13-21(14-12-19)25(27)28)24(34)22(10-7-15-31-26(29)30)33-37(35,36)17-20-8-5-4-6-9-20/h4-6,8-9,11-14,18,22-23,32-33H,3,7,10,15-17H2,1-2H3,(H3,27,28)(H4,29,30,31)/t18-,22+,23-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349344
(CHEMBL1809250)Show SMILES CCC(NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H35N7O3S/c1-2-20(30-15-17-10-12-19(13-11-17)23(25)26)22(32)21(9-6-14-29-24(27)28)31-35(33,34)16-18-7-4-3-5-8-18/h3-5,7-8,10-13,20-21,30-31H,2,6,9,14-16H2,1H3,(H3,25,26)(H4,27,28,29)/t20?,21-/m1/s1 | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349348
(CHEMBL1809254)Show SMILES C[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C23H33N7O3S/c1-16(29-14-17-9-11-19(12-10-17)22(24)25)21(31)20(8-5-13-28-23(26)27)30-34(32,33)15-18-6-3-2-4-7-18/h2-4,6-7,9-12,16,20,29-30H,5,8,13-15H2,1H3,(H3,24,25)(H4,26,27,28)/t16-,20+/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349357
(CHEMBL1809214)Show SMILES CC(C)(C)OC(=O)CC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C29H39N5O6S/c1-29(2,3)40-25(35)16-15-23(33-41(38,39)19-21-8-5-4-6-9-21)28(37)34-17-7-10-24(34)27(36)32-18-20-11-13-22(14-12-20)26(30)31/h4-6,8-9,11-14,23-24,33H,7,10,15-19H2,1-3H3,(H3,30,31)(H,32,36)/t23-,24+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349349
(CHEMBL1809255)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C34H46N8O5S/c35-32(36)28-18-16-25(17-19-28)22-41-29(14-7-8-20-40-34(44)47-23-26-10-3-1-4-11-26)31(43)30(15-9-21-39-33(37)38)42-48(45,46)24-27-12-5-2-6-13-27/h1-6,10-13,16-19,29-30,41-42H,7-9,14-15,20-24H2,(H3,35,36)(H,40,44)(H4,37,38,39)/t29-,30+/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349350
(CHEMBL1809256)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](CO)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C23H33N7O4S/c24-22(25)18-10-8-16(9-11-18)13-29-20(14-31)21(32)19(7-4-12-28-23(26)27)30-35(33,34)15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19-20,29-31H,4,7,12-15H2,(H3,24,25)(H4,26,27,28)/t19-,20+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349357
(CHEMBL1809214)Show SMILES CC(C)(C)OC(=O)CC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C29H39N5O6S/c1-29(2,3)40-25(35)16-15-23(33-41(38,39)19-21-8-5-4-6-9-21)28(37)34-17-7-10-24(34)27(36)32-18-20-11-13-22(14-12-20)26(30)31/h4-6,8-9,11-14,23-24,33H,7,10,15-19H2,1-3H3,(H3,30,31)(H,32,36)/t23-,24+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349345
(CHEMBL1809251)Show SMILES CCC[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-2-7-21(31-16-18-11-13-20(14-12-18)24(26)27)23(33)22(10-6-15-30-25(28)29)32-36(34,35)17-19-8-4-3-5-9-19/h3-5,8-9,11-14,21-22,31-32H,2,6-7,10,15-17H2,1H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349334
(CHEMBL1809239)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)C(=O)OCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C37H45N7O7S/c38-34(39)30-15-13-27(14-16-30)24-40-35(46)32-12-7-19-44(32)36(47)31(41-52(49,50)26-29-10-5-2-6-11-29)17-18-33(45)42-20-22-43(23-21-42)37(48)51-25-28-8-3-1-4-9-28/h1-6,8-11,13-16,31-32,41H,7,12,17-26H2,(H3,38,39)(H,40,46)/t31-,32+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349361
(CHEMBL1809215)Show SMILES CC(C)(C)OC(=O)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C28H37N5O6S/c1-28(2,3)39-24(34)16-22(32-40(37,38)18-20-8-5-4-6-9-20)27(36)33-15-7-10-23(33)26(35)31-17-19-11-13-21(14-12-19)25(29)30/h4-6,8-9,11-14,22-23,32H,7,10,15-18H2,1-3H3,(H3,29,30)(H,31,35)/t22-,23+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349358
(CHEMBL1809216)Show SMILES NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N6O4S/c27-15-5-4-9-22(31-37(35,36)18-20-7-2-1-3-8-20)26(34)32-16-6-10-23(32)25(33)30-17-19-11-13-21(14-12-19)24(28)29/h1-3,7-8,11-14,22-23,31H,4-6,9-10,15-18,27H2,(H3,28,29)(H,30,33)/t22-,23+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349335
(CHEMBL1809240)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N2CCN(CC2)c2ncccn2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C32H39N9O5S/c33-29(34)25-11-9-23(10-12-25)21-37-30(43)27-8-4-15-41(27)31(44)26(38-47(45,46)22-24-6-2-1-3-7-24)20-28(42)39-16-18-40(19-17-39)32-35-13-5-14-36-32/h1-3,5-7,9-14,26-27,38H,4,8,15-22H2,(H3,33,34)(H,37,43)/t26-,27+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349351
(CHEMBL1809257)Show SMILES CC(C)C[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H39N7O3S/c1-18(2)15-23(32-16-19-10-12-21(13-11-19)25(27)28)24(34)22(9-6-14-31-26(29)30)33-37(35,36)17-20-7-4-3-5-8-20/h3-5,7-8,10-13,18,22-23,32-33H,6,9,14-17H2,1-2H3,(H3,27,28)(H4,29,30,31)/t22-,23+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
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PC sid
UniChem
Similars
| Article
PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349360
(CHEMBL1809212)Show SMILES NC(=N)c1ccc(CNC(=O)[C@H](CCCCNC(=O)OCc2ccccc2)NC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C32H40N6O7S/c33-29(34)26-16-14-23(15-17-26)19-36-30(40)27(13-7-8-18-35-32(42)45-21-24-9-3-1-4-10-24)37-31(41)28(20-39)38-46(43,44)22-25-11-5-2-6-12-25/h1-6,9-12,14-17,27-28,38-39H,7-8,13,18-22H2,(H3,33,34)(H,35,42)(H,36,40)(H,37,41)/t27-,28+/m0/s1 | KEGG
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PC sid
UniChem
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| Article
PubMed
| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349358
(CHEMBL1809216)Show SMILES NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N6O4S/c27-15-5-4-9-22(31-37(35,36)18-20-7-2-1-3-8-20)26(34)32-16-6-10-23(32)25(33)30-17-19-11-13-21(14-12-19)24(28)29/h1-3,7-8,11-14,22-23,31H,4-6,9-10,15-18,27H2,(H3,28,29)(H,30,33)/t22-,23+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 52 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349362
(CHEMBL1809217)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCNC(=O)OCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C34H42N6O6S/c35-31(36)28-18-16-25(17-19-28)22-38-32(41)30-15-9-21-40(30)33(42)29(39-47(44,45)24-27-12-5-2-6-13-27)14-7-8-20-37-34(43)46-23-26-10-3-1-4-11-26/h1-6,10-13,16-19,29-30,39H,7-9,14-15,20-24H2,(H3,35,36)(H,37,43)(H,38,41)/t29-,30+/m1/s1 | KEGG
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 2
(Homo sapiens (Human)) | BDBM50349344
(CHEMBL1809250)Show SMILES CCC(NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H35N7O3S/c1-2-20(30-15-17-10-12-19(13-11-17)23(25)26)22(32)21(9-6-14-29-24(27)28)31-35(33,34)16-18-7-4-3-5-8-18/h3-5,7-8,10-13,20-21,30-31H,2,6,9,14-16H2,1H3,(H3,25,26)(H4,27,28,29)/t20?,21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC cid
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UniChem
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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PDB
UniChem
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| Article
PubMed
| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of matriptase |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349352
(CHEMBL1809258)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C29H37N7O3S/c30-28(31)24-15-13-22(14-16-24)19-35-26(18-21-8-3-1-4-9-21)27(37)25(12-7-17-34-29(32)33)36-40(38,39)20-23-10-5-2-6-11-23/h1-6,8-11,13-16,25-26,35-36H,7,12,17-20H2,(H3,30,31)(H4,32,33,34)/t25-,26+/m1/s1 | KEGG
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349363
(CHEMBL1809218)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C30H35N5O4S/c31-28(32)25-16-13-23(14-17-25)20-33-29(36)27-12-7-19-35(27)30(37)26(18-15-22-8-3-1-4-9-22)34-40(38,39)21-24-10-5-2-6-11-24/h1-6,8-11,13-14,16-17,26-27,34H,7,12,15,18-21H2,(H3,31,32)(H,33,36)/t26-,27+/m1/s1 | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349358
(CHEMBL1809216)Show SMILES NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N6O4S/c27-15-5-4-9-22(31-37(35,36)18-20-7-2-1-3-8-20)26(34)32-16-6-10-23(32)25(33)30-17-19-11-13-21(14-12-19)24(28)29/h1-3,7-8,11-14,22-23,31H,4-6,9-10,15-18,27H2,(H3,28,29)(H,30,33)/t22-,23+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349346
(CHEMBL1809252)Show SMILES CC(C)[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-17(2)22(31-15-18-10-12-20(13-11-18)24(26)27)23(33)21(9-6-14-30-25(28)29)32-36(34,35)16-19-7-4-3-5-8-19/h3-5,7-8,10-13,17,21-22,31-32H,6,9,14-16H2,1-2H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m1/s1 | PDB
Reactome pathway
UniProtKB/SwissProt
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PC sid
UniChem
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PubMed
| 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349345
(CHEMBL1809251)Show SMILES CCC[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-2-7-21(31-16-18-11-13-20(14-12-18)24(26)27)23(33)22(10-6-15-30-25(28)29)32-36(34,35)17-19-8-4-3-5-9-19/h3-5,8-9,11-14,21-22,31-32H,2,6-7,10,15-17H2,1H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt
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GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 2
(Homo sapiens (Human)) | BDBM50349345
(CHEMBL1809251)Show SMILES CCC[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-2-7-21(31-16-18-11-13-20(14-12-18)24(26)27)23(33)22(10-6-15-30-25(28)29)32-36(34,35)17-19-8-4-3-5-9-19/h3-5,8-9,11-14,21-22,31-32H,2,6-7,10,15-17H2,1H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescenc... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349336
(CHEMBL1809241)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C29H39N7O5S/c30-27(31)23-10-8-21(9-11-23)19-33-28(38)25-7-4-16-36(25)29(39)24(12-13-26(37)35-17-14-32-15-18-35)34-42(40,41)20-22-5-2-1-3-6-22/h1-3,5-6,8-11,24-25,32,34H,4,7,12-20H2,(H3,30,31)(H,33,38)/t24-,25+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349337
(CHEMBL1809242)Show SMILES Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C36H45N7O5S/c1-25-10-11-26(2)32(21-25)41-17-19-42(20-18-41)33(44)22-30(40-49(47,48)24-28-7-4-3-5-8-28)36(46)43-16-6-9-31(43)35(45)39-23-27-12-14-29(15-13-27)34(37)38/h3-5,7-8,10-15,21,30-31,40H,6,9,16-20,22-24H2,1-2H3,(H3,37,38)(H,39,45)/t30-,31+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349348
(CHEMBL1809254)Show SMILES C[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C23H33N7O3S/c1-16(29-14-17-9-11-19(12-10-17)22(24)25)21(31)20(8-5-13-28-23(26)27)30-34(32,33)15-18-6-3-2-4-7-18/h2-4,6-7,9-12,16,20,29-30H,5,8,13-15H2,1H3,(H3,24,25)(H4,26,27,28)/t16-,20+/m0/s1 | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349364
(CHEMBL1809219)Show SMILES CC(C)[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C25H33N5O4S/c1-17(2)22(29-35(33,34)16-19-7-4-3-5-8-19)25(32)30-14-6-9-21(30)24(31)28-15-18-10-12-20(13-11-18)23(26)27/h3-5,7-8,10-13,17,21-22,29H,6,9,14-16H2,1-2H3,(H3,26,27)(H,28,31)/t21-,22+/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50231520
((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)Show SMILES NC(=N)c1ccc(CNC(=O)[C@H](CO)NC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C21H27N5O6S/c22-19(23)16-8-6-14(7-9-16)10-24-20(29)17(11-27)25-21(30)18(12-28)26-33(31,32)13-15-4-2-1-3-5-15/h1-9,17-18,26-28H,10-13H2,(H3,22,23)(H,24,29)(H,25,30)/t17-,18+/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349365
(CHEMBL1809220)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C29H33N5O4S/c30-27(31)24-15-13-22(14-16-24)19-32-28(35)26-12-7-17-34(26)29(36)25(18-21-8-3-1-4-9-21)33-39(37,38)20-23-10-5-2-6-11-23/h1-6,8-11,13-16,25-26,33H,7,12,17-20H2,(H3,30,31)(H,32,35)/t25-,26+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50324477
(Benzylsulfonyl-D-cyclohexylalanyl-proline-(4-amidi...)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2CCCCC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C29H39N5O4S/c30-27(31)24-15-13-22(14-16-24)19-32-28(35)26-12-7-17-34(26)29(36)25(18-21-8-3-1-4-9-21)33-39(37,38)20-23-10-5-2-6-11-23/h2,5-6,10-11,13-16,21,25-26,33H,1,3-4,7-9,12,17-20H2,(H3,30,31)(H,32,35)/t25-,26+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 108 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349336
(CHEMBL1809241)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C29H39N7O5S/c30-27(31)23-10-8-21(9-11-23)19-33-28(38)25-7-4-16-36(25)29(39)24(12-13-26(37)35-17-14-32-15-18-35)34-42(40,41)20-22-5-2-1-3-6-22/h1-3,5-6,8-11,24-25,32,34H,4,7,12-20H2,(H3,30,31)(H,33,38)/t24-,25+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 114 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349367
(CHEMBL1809234)Show SMILES CC(C)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H35N5O4S/c1-18(2)15-22(30-36(34,35)17-20-7-4-3-5-8-20)26(33)31-14-6-9-23(31)25(32)29-16-19-10-12-21(13-11-19)24(27)28/h3-5,7-8,10-13,18,22-23,30H,6,9,14-17H2,1-2H3,(H3,27,28)(H,29,32)/t22-,23+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349333
(CHEMBL1809238)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)c2ncccn2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C33H41N9O5S/c34-30(35)26-11-9-24(10-12-26)22-38-31(44)28-8-4-17-42(28)32(45)27(39-48(46,47)23-25-6-2-1-3-7-25)13-14-29(43)40-18-20-41(21-19-40)33-36-15-5-16-37-33/h1-3,5-7,9-12,15-16,27-28,39H,4,8,13-14,17-23H2,(H3,34,35)(H,38,44)/t27-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349371
(CHEMBL1809243)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N2CCN(CC2)C(=O)OCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C36H43N7O7S/c37-33(38)29-15-13-26(14-16-29)23-39-34(45)31-12-7-17-43(31)35(46)30(40-51(48,49)25-28-10-5-2-6-11-28)22-32(44)41-18-20-42(21-19-41)36(47)50-24-27-8-3-1-4-9-27/h1-6,8-11,13-16,30-31,40H,7,12,17-25H2,(H3,37,38)(H,39,45)/t30-,31+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349338
(CHEMBL1809244)Show SMILES CN(C)CCCN1CCN(CC1)C(=O)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C33H48N8O5S/c1-38(2)15-7-16-39-18-20-40(21-19-39)30(42)22-28(37-47(45,46)24-26-8-4-3-5-9-26)33(44)41-17-6-10-29(41)32(43)36-23-25-11-13-27(14-12-25)31(34)35/h3-5,8-9,11-14,28-29,37H,6-7,10,15-24H2,1-2H3,(H3,34,35)(H,36,43)/t28-,29+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 149 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349339
(CHEMBL1809245)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N2CCN(Cc3ccccc3)CC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C35H43N7O5S/c36-33(37)29-15-13-26(14-16-29)23-38-34(44)31-12-7-17-42(31)35(45)30(39-48(46,47)25-28-10-5-2-6-11-28)22-32(43)41-20-18-40(19-21-41)24-27-8-3-1-4-9-27/h1-6,8-11,13-16,30-31,39H,7,12,17-25H2,(H3,36,37)(H,38,44)/t30-,31+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349350
(CHEMBL1809256)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](CO)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C23H33N7O4S/c24-22(25)18-10-8-16(9-11-18)13-29-20(14-31)21(32)19(7-4-12-28-23(26)27)30-35(33,34)15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19-20,29-31H,4,7,12-15H2,(H3,24,25)(H4,26,27,28)/t19-,20+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 161 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349368
(CHEMBL1809235)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(cc2)C(N)=N)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C30H35N7O4S/c31-27(32)23-12-8-20(9-13-23)17-25(36-42(40,41)19-22-5-2-1-3-6-22)30(39)37-16-4-7-26(37)29(38)35-18-21-10-14-24(15-11-21)28(33)34/h1-3,5-6,8-15,25-26,36H,4,7,16-19H2,(H3,31,32)(H3,33,34)(H,35,38)/t25-,26+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 168 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 6
(Homo sapiens (Human)) | BDBM50324475
(Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzy...)Show SMILES NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C26H36N8O4S/c27-23(28)20-12-10-18(11-13-20)16-32-24(35)22-9-5-15-34(22)25(36)21(8-4-14-31-26(29)30)33-39(37,38)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,33H,4-5,8-9,14-17H2,(H3,27,28)(H,32,35)(H4,29,30,31)/t21-,22+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of matriptase 2 |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349340
(CHEMBL1809246)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N2CCOCC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C28H36N6O6S/c29-26(30)22-10-8-20(9-11-22)18-31-27(36)24-7-4-12-34(24)28(37)23(17-25(35)33-13-15-40-16-14-33)32-41(38,39)19-21-5-2-1-3-6-21/h1-3,5-6,8-11,23-24,32H,4,7,12-19H2,(H3,29,30)(H,31,36)/t23-,24+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 183 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349341
(CHEMBL1809247)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C28H37N7O5S/c29-26(30)22-10-8-20(9-11-22)18-32-27(37)24-7-4-14-35(24)28(38)23(17-25(36)34-15-12-31-13-16-34)33-41(39,40)19-21-5-2-1-3-6-21/h1-3,5-6,8-11,23-24,31,33H,4,7,12-19H2,(H3,29,30)(H,32,37)/t23-,24+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 202 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349342
(CHEMBL1809248)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N2CCN(CCO)CC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C30H41N7O6S/c31-28(32)24-10-8-22(9-11-24)20-33-29(40)26-7-4-12-37(26)30(41)25(34-44(42,43)21-23-5-2-1-3-6-23)19-27(39)36-15-13-35(14-16-36)17-18-38/h1-3,5-6,8-11,25-26,34,38H,4,7,12-21H2,(H3,31,32)(H,33,40)/t25-,26+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349343
(CHEMBL1809249)Show SMILES CC(C)N1CCN(CC1)C(=O)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C31H43N7O5S/c1-22(2)36-15-17-37(18-16-36)28(39)19-26(35-44(42,43)21-24-7-4-3-5-8-24)31(41)38-14-6-9-27(38)30(40)34-20-23-10-12-25(13-11-23)29(32)33/h3-5,7-8,10-13,22,26-27,35H,6,9,14-21H2,1-2H3,(H3,32,33)(H,34,40)/t26-,27+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 221 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349369
(CHEMBL1809236)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(cc2)C#N)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C30H32N6O4S/c31-18-22-10-8-21(9-11-22)17-26(35-41(39,40)20-24-5-2-1-3-6-24)30(38)36-16-4-7-27(36)29(37)34-19-23-12-14-25(15-13-23)28(32)33/h1-3,5-6,8-15,26-27,35H,4,7,16-17,19-20H2,(H3,32,33)(H,34,37)/t26-,27+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 311 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349334
(CHEMBL1809239)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)C(=O)OCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C37H45N7O7S/c38-34(39)30-15-13-27(14-16-30)24-40-35(46)32-12-7-19-44(32)36(47)31(41-52(49,50)26-29-10-5-2-6-11-29)17-18-33(45)42-20-22-43(23-21-42)37(48)51-25-28-8-3-1-4-9-28/h1-6,8-11,13-16,31-32,41H,7,12,17-26H2,(H3,38,39)(H,40,46)/t31-,32+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 397 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349353
(CHEMBL1809259)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](CC(O)=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C24H33N7O5S/c25-23(26)18-10-8-16(9-11-18)14-30-20(13-21(32)33)22(34)19(7-4-12-29-24(27)28)31-37(35,36)15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19-20,30-31H,4,7,12-15H2,(H3,25,26)(H,32,33)(H4,27,28,29)/t19-,20+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 422 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349359
(CHEMBL1809211)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)NCC(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C23H32N8O4S/c24-21(25)18-10-8-16(9-11-18)13-29-20(32)14-30-22(33)19(7-4-12-28-23(26)27)31-36(34,35)15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19,31H,4,7,12-15H2,(H3,24,25)(H,29,32)(H,30,33)(H4,26,27,28)/t19-/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349372
(CHEMBL1809260)Show SMILES NC(N)=NCCC[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C26H40N10O3S/c27-24(28)20-12-10-18(11-13-20)16-35-21(8-4-14-33-25(29)30)23(37)22(9-5-15-34-26(31)32)36-40(38,39)17-19-6-2-1-3-7-19/h1-3,6-7,10-13,21-22,35-36H,4-5,8-9,14-17H2,(H3,27,28)(H4,29,30,33)(H4,31,32,34)/t21-,22+/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 457 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349354
(CHEMBL1809261)Show SMILES CC(C)(C)OC(=O)C[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C28H41N7O5S/c1-28(2,3)40-24(36)16-23(34-17-19-11-13-21(14-12-19)26(29)30)25(37)22(10-7-15-33-27(31)32)35-41(38,39)18-20-8-5-4-6-9-20/h4-6,8-9,11-14,22-23,34-35H,7,10,15-18H2,1-3H3,(H3,29,30)(H4,31,32,33)/t22-,23+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 512 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50349336
(CHEMBL1809241)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C29H39N7O5S/c30-27(31)23-10-8-21(9-11-23)19-33-28(38)25-7-4-16-36(25)29(39)24(12-13-26(37)35-17-14-32-15-18-35)34-42(40,41)20-22-5-2-1-3-6-22/h1-3,5-6,8-11,24-25,32,34H,4,7,12-20H2,(H3,30,31)(H,33,38)/t24-,25+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 565 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of factor 10a |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349348
(CHEMBL1809254)Show SMILES C[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C23H33N7O3S/c1-16(29-14-17-9-11-19(12-10-17)22(24)25)21(31)20(8-5-13-28-23(26)27)30-34(32,33)15-18-6-3-2-4-7-18/h2-4,6-7,9-12,16,20,29-30H,5,8,13-15H2,1H3,(H3,24,25)(H4,26,27,28)/t16-,20+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349334
(CHEMBL1809239)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)C(=O)OCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C37H45N7O7S/c38-34(39)30-15-13-27(14-16-30)24-40-35(46)32-12-7-19-44(32)36(47)31(41-52(49,50)26-29-10-5-2-6-11-29)17-18-33(45)42-20-22-43(23-21-42)37(48)51-25-28-8-3-1-4-9-28/h1-6,8-11,13-16,31-32,41H,7,12,17-26H2,(H3,38,39)(H,40,46)/t31-,32+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Transmembrane protease serine 11D
(Homo sapiens (Human)) | BDBM50349370
(CHEMBL1809237)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(O)=O)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C24H29N5O6S/c25-22(26)18-10-8-16(9-11-18)14-27-23(32)20-7-4-12-29(20)24(33)19(13-21(30)31)28-36(34,35)15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19-20,28H,4,7,12-15H2,(H3,25,26)(H,27,32)(H,30,31)/t19-,20+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader anal... |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349357
(CHEMBL1809214)Show SMILES CC(C)(C)OC(=O)CC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C29H39N5O6S/c1-29(2,3)40-25(35)16-15-23(33-41(38,39)19-21-8-5-4-6-9-21)28(37)34-17-7-10-24(34)27(36)32-18-20-11-13-22(14-12-20)26(30)31/h4-6,8-9,11-14,23-24,33H,7,10,15-19H2,1-3H3,(H3,30,31)(H,32,36)/t23-,24+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50349350
(CHEMBL1809256)Show SMILES NC(N)=NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](CO)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C23H33N7O4S/c24-22(25)18-10-8-16(9-11-18)13-29-20(14-31)21(32)19(7-4-12-28-23(26)27)30-35(33,34)15-17-5-2-1-3-6-17/h1-3,5-6,8-11,19-20,29-31H,4,7,12-15H2,(H3,24,25)(H4,26,27,28)/t19-,20+/m1/s1 | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of thrombin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349345
(CHEMBL1809251)Show SMILES CCC[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-2-7-21(31-16-18-11-13-20(14-12-18)24(26)27)23(33)22(10-6-15-30-25(28)29)32-36(34,35)17-19-8-4-3-5-9-19/h3-5,8-9,11-14,21-22,31-32H,2,6-7,10,15-17H2,1H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349346
(CHEMBL1809252)Show SMILES CC(C)[C@H](NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C25H37N7O3S/c1-17(2)22(31-15-18-10-12-20(13-11-18)24(26)27)23(33)21(9-6-14-30-25(28)29)32-36(34,35)16-19-7-4-3-5-8-19/h3-5,7-8,10-13,17,21-22,31-32H,6,9,14-16H2,1-2H3,(H3,26,27)(H4,28,29,30)/t21-,22+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349344
(CHEMBL1809250)Show SMILES CCC(NCc1ccc(cc1)C(N)=N)C(=O)[C@@H](CCCN=C(N)N)NS(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C24H35N7O3S/c1-2-20(30-15-17-10-12-19(13-11-17)23(25)26)22(32)21(9-6-14-29-24(27)28)31-35(33,34)16-18-7-4-3-5-8-18/h3-5,7-8,10-13,20-21,30-31H,2,6,9,14-16H2,1H3,(H3,25,26)(H4,27,28,29)/t20?,21-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50349333
(CHEMBL1809238)Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCN(CC2)c2ncccn2)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C33H41N9O5S/c34-30(35)26-11-9-24(10-12-26)22-38-31(44)28-8-4-17-42(28)32(45)27(39-48(46,47)23-25-6-2-1-3-7-25)13-14-29(43)40-18-20-41(21-19-40)33-36-15-5-16-37-33/h1-3,5-7,9-12,15-16,27-28,39H,4,8,13-14,17-23H2,(H3,34,35)(H,38,44)/t27-,28+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Philipps University Marburg
Curated by ChEMBL
| Assay Description
Inhibition of plasmin |
Bioorg Med Chem Lett 21: 4860-4 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.033
BindingDB Entry DOI: 10.7270/Q2ST7Q5M |
More data for this
Ligand-Target Pair | |
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