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Found 75 Enz. Inhib. hit(s) with all data for entry = 50034391
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361634(CHEMBL1939877 | US8785489, (4-{[({5-[2-(ethoxycarb...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of AMPA-activated MMP13-mediated degradation of FITC-labeled type2 collagen after 1.5 hrs by fluorimetryMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361634(CHEMBL1939877 | US8785489, (4-{[({5-[2-(ethoxycarb...)
Affinity DataIC50:  14nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human MMP13-mediated degradation of bovine nasal cartilage after 2 hrs by ELISA in the presence of 10% human serumMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361632(CHEMBL1939874 | US8785489, ethyl 5-{1-methyl-3-[(p...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361633(CHEMBL1939875 | US8785489, ethyl 5-(1-methyl-3-{[(...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361638(CHEMBL1939881)
Affinity DataIC50:  250nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361633(CHEMBL1939875 | US8785489, ethyl 5-(1-methyl-3-{[(...)
Affinity DataIC50:  280nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361632(CHEMBL1939874 | US8785489, ethyl 5-{1-methyl-3-[(p...)
Affinity DataIC50:  360nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50:  640nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361638(CHEMBL1939881)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361631(CHEMBL1939873)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361630(CHEMBL1939872)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human recombinant MMP9 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361629(CHEMBL1939871)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361633(CHEMBL1939875 | US8785489, ethyl 5-(1-methyl-3-{[(...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361630(CHEMBL1939872)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361627(CHEMBL1939869)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of human recombinant MMP10 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361634(CHEMBL1939877 | US8785489, (4-{[({5-[2-(ethoxycarb...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP3 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP8 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP7 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361635(CHEMBL1939878 | US8785489, ethyl 5-{5-methyl-2-[(p...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361634(CHEMBL1939877 | US8785489, (4-{[({5-[2-(ethoxycarb...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP1 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant MMP12 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361633(CHEMBL1939875 | US8785489, ethyl 5-(1-methyl-3-{[(...)
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361630(CHEMBL1939872)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361636(CHEMBL1939879)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361637(CHEMBL1939880)
Affinity DataIC50: >2.60E+4nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4 using 7-benzyloxy-4-trifluoromethylcoumarin as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin as substrate after 45 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361627(CHEMBL1939869)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361623(CHEMBL1939865)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361620(CHEMBL1939862)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361631(CHEMBL1939873)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361627(CHEMBL1939869)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361636(CHEMBL1939879)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of MMP13 after 30 mins by fluorimetry in the presence of 1.25% human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361620(CHEMBL1939862)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361628(CHEMBL1939870)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361631(CHEMBL1939873)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361619(CHEMBL1939861)
Affinity DataIC50:  9.70E+4nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50361619(CHEMBL1939861)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibition of human recombinant MMP2 after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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