Compile Data Set for Download or QSAR
maximum 50k data
Found 98 Enz. Inhib. hit(s) with all data for entry = 50040558
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataKi:  1.80nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50325991(2-(7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-...)
Affinity DataKi:  7.5nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396074(CHEMBL2170585)
Affinity DataKi:  10nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataKi:  30nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKi:  30nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataKi:  35nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50249090(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)
Affinity DataKi:  96nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataKi:  116nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataKi:  130nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50290422(4-(4-Methyl-piperazin-1-ylmethyl)-N-[3-(4-pyridin-...)
Affinity DataKi:  160nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396071(CHEMBL2170582 | US10828301, Compound R921303)
Affinity DataKi:  217nMAssay Description:Inhibition of FGFR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50:  5nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in Anti-IgG-stimulated FcgammaR-mediated leukotriene LTC4 production by fluoresce...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  5nMAssay Description:Inhibition of Ret by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126413(CHEMBL287478 | N*1*-[7-(4-Morpholin-4-yl-phenyl)-[...)
Affinity DataIC50:  8nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50132443(4-{5-Methoxy-3-[2-oxo-5-sulfamoyl-1,2-dihydro-indo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50132436(3-((1-methyl-1H-indol-3-yl)methylene)-2-oxoindolin...)
Affinity DataIC50:  14nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126419(CHEMBL282342 | N*1*-[7-(4-Dimethylamino-phenyl)-[1...)
Affinity DataIC50:  19nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50132433(3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50132437(3-((1-(3-hydroxypropyl)-5-methoxy-1H-indol-3-yl)me...)
Affinity DataIC50:  32nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126443(CHEMBL30678 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Affinity DataIC50:  34nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataIC50:  41nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in Anti-IgG-stimulated FcgammaR-mediated leukotriene LTC4 production by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126410(CHEMBL30548 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Affinity DataIC50:  72nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126440(CHEMBL30824 | N-[7-(4-Dimethylamino-phenyl)-[1,6]n...)
Affinity DataIC50:  78nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126400(CHEMBL30873 | N*1*-[7-(4-Isopropyl-phenyl)-[1,6]na...)
Affinity DataIC50:  90nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126411(CHEMBL284675 | N*1*-[7-(4-Methoxy-phenyl)-[1,6]nap...)
Affinity DataIC50:  140nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50132451(3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-N-...)
Affinity DataIC50:  145nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126436(4-(5-(4-aminobutoxy)-1,6-naphthyridin-7-yl)-N,N-di...)
Affinity DataIC50:  160nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126437(CHEMBL30826 | N*1*-[7-(4-Dimethylamino-phenyl)-[1,...)
Affinity DataIC50:  190nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126423(4-[7-(4-Dimethylamino-phenyl)-[1,6]naphthyridin-5-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126442(CHEMBL285916 | N*1*-[7-(3-Chloro-phenyl)-[1,6]naph...)
Affinity DataIC50:  260nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126420(CHEMBL285346 | N*1*-[7-(4-Bromo-phenyl)-[1,6]napht...)
Affinity DataIC50:  260nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50132435(3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-2-...)
Affinity DataIC50:  273nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126403(CHEMBL33009 | N*1*-(7-{4-[(3-Dimethylamino-propyl)...)
Affinity DataIC50:  420nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126439(CHEMBL30774 | [7-(4-Methoxy-phenyl)-[1,6]naphthyri...)
Affinity DataIC50:  490nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396077(CHEMBL1229525)
Affinity DataIC50:  570nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in Anti-IgG-stimulated FcgammaR-mediated leukotriene LTC4 production by fluoresce...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126421(CHEMBL30885 | N*1*-[7-(3-Fluoro-phenyl)-[1,6]napht...)
Affinity DataIC50:  850nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126441(CHEMBL30661 | N*1*-[7-(4-Fluoro-phenyl)-[1,6]napht...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126414(CHEMBL30240 | N*1*-[7-(4-Chloro-phenyl)-[1,6]napht...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50126446(CHEMBL31668 | N*1*-[7-(4-Methoxy-phenyl)-[1,6]naph...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50132442(3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel

Curated by ChEMBL
LigandPNGBDBM50396076(CHEMBL2170739)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of SYK in human mast cells by immunoprecipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Rattus norvegicus)
Rigel

Curated by ChEMBL
LigandPNGBDBM50396076(CHEMBL2170739)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of SYK in rat RBL2H3 cells by immunoprecipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Rattus norvegicus)
Rigel

Curated by ChEMBL
LigandPNGBDBM50396076(CHEMBL2170739)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated TNFalpha releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Rattus norvegicus)
Rigel

Curated by ChEMBL
LigandPNGBDBM50396076(CHEMBL2170739)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated 5-HT releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Rattus norvegicus)
Rigel

Curated by ChEMBL
LigandPNGBDBM50396076(CHEMBL2170739)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated inositol phosphate releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Rattus norvegicus)
Rigel

Curated by ChEMBL
LigandPNGBDBM50396076(CHEMBL2170739)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of SYK in rat RBL2H3 cells assessed as reduction in DNP-BSA-stimulated Fcepsilon receptor 1-mediated arachidonic acid releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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