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Found 19 Enz. Inhib. hit(s) with all data for entry = 50040034
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388189(CHEMBL2057918)
Affinity DataIC50:  0.300nMAssay Description:Competitive inhibition of BTK by TR-FRET based competitive assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BLKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388185(CHEMBL2057919)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BMXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388190(CHEMBL2057923)
Affinity DataIC50:  1nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50357333(CHEMBL1916891)
Affinity DataIC50:  1.93nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388181(CHEMBL2057913)
Affinity DataIC50:  2nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388183(CHEMBL2057915)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388180(CHEMBL2057912)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388185(CHEMBL2057919)
Affinity DataIC50:  11nMAssay Description:Inhibition of BTK in human Ramos cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388186(CHEMBL2057920)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388184(CHEMBL2057916)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388188(CHEMBL2057922)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  37nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388187(CHEMBL2057921)
Affinity DataIC50:  144nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50388182(CHEMBL2057914)
Affinity DataIC50:  400nMAssay Description:Inhibition of human BTK by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50357333(CHEMBL1916891)
Affinity DataIC50:  624nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM24941((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant BTK expressed in baculovirus expression vector systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed