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PubMed code 22858141

Compile data set for download or QSAR
Found 113 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 8


(Homo sapiens)
BDBM50390333
PNG
(CHEMBL2070733)
Show SMILES Nc1nc(nc2n(C[C@H]3CN(Cc4nccs4)CCO3)nnc12)C1CC1
Show InChI InChI=1S/C16H20N8OS/c17-14-13-16(20-15(19-14)10-1-2-10)24(22-21-13)8-11-7-23(4-5-25-11)9-12-18-3-6-26-12/h3,6,10-11H,1-2,4-5,7-9H2,(H2,17,19,20)/t11-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390334
PNG
(CHEMBL2070735)
Show SMILES Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1
Show InChI InChI=1S/C14H18N8OS/c1-9-17-13(15)12-14(18-9)22(20-19-12)7-10-6-21(3-4-23-10)8-11-16-2-5-24-11/h2,5,10H,3-4,6-8H2,1H3,(H2,15,17,18)/t10-/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390332
PNG
(CHEMBL2070732)
Show SMILES Nc1nc(nc2n(C[C@H]3CN(Cc4ccccn4)CCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C16H17F3N8O/c17-16(18,19)15-22-13(20)12-14(23-15)27(25-24-12)9-11-8-26(5-6-28-11)7-10-3-1-2-4-21-10/h1-4,11H,5-9H2,(H2,20,22,23)/t11-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (human))
BDBM50390334
PNG
(CHEMBL2070735)
Show SMILES Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1
Show InChI InChI=1S/C14H18N8OS/c1-9-17-13(15)12-14(18-9)22(20-19-12)7-10-6-21(3-4-23-10)8-11-16-2-5-24-11/h2,5,10H,3-4,6-8H2,1H3,(H2,15,17,18)/t10-/m1/s1
PDB
MMDB

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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8A


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390373
PNG
(CHEMBL2070914)
Show SMILES Nc1nc(nc2n(CC3OCCc4ccccc34)nnc12)C1CC1
Show InChI InChI=1S/C17H18N6O/c18-15-14-17(20-16(19-15)11-5-6-11)23(22-21-14)9-13-12-4-2-1-3-10(12)7-8-24-13/h1-4,11,13H,5-9H2,(H2,18,19,20)
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n/an/a 3.63n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390335
PNG
(CHEMBL2070736)
Show SMILES CCc1csc(CN2CCO[C@@H](Cn3nnc4c(N)nc(C)nc34)C2)n1
Show InChI InChI=1S/C16H22N8OS/c1-3-11-9-26-13(20-11)8-23-4-5-25-12(6-23)7-24-16-14(21-22-24)15(17)18-10(2)19-16/h9,12H,3-8H2,1-2H3,(H2,17,18,19)/t12-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390366
PNG
(CHEMBL2070935)
Show SMILES CC(C)(C)c1cc(Cn2nnc3c(N)nc(nc23)C2CC2)[nH]n1
Show InChI InChI=1S/C15H20N8/c1-15(2,3)10-6-9(19-20-10)7-23-14-11(21-22-23)12(16)17-13(18-14)8-4-5-8/h6,8H,4-5,7H2,1-3H3,(H,19,20)(H2,16,17,18)
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n/an/a 6.79n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390324
PNG
(CHEMBL2070604)
Show SMILES Nc1nc(nc2n(Cc3cc(n[nH]3)C3CC3)nnc12)C1CC1
Show InChI InChI=1S/C14H16N8/c15-12-11-14(17-13(16-12)8-3-4-8)22(21-20-11)6-9-5-10(19-18-9)7-1-2-7/h5,7-8H,1-4,6H2,(H,18,19)(H2,15,16,17)
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n/an/a 6.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390313
PNG
(CHEMBL2070595)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)C1CC1
Show InChI InChI=1S/C13H18N6O/c14-11-10-13(16-12(15-11)8-4-5-8)19(18-17-10)7-9-3-1-2-6-20-9/h8-9H,1-7H2,(H2,14,15,16)
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n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390352
PNG
(CHEMBL2070901)
Show SMILES Nc1nc(CSc2ccccc2)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C17H20N6OS/c18-16-15-17(23(22-21-15)10-12-6-4-5-9-24-12)20-14(19-16)11-25-13-7-2-1-3-8-13/h1-3,7-8,12H,4-6,9-11H2,(H2,18,19,20)
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n/an/a 12.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390367
PNG
(CHEMBL2070907)
Show SMILES Cc1nc(cs1)-c1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C14H17N7OS/c1-8-16-10(7-23-8)13-17-12(15)11-14(18-13)21(20-19-11)6-9-4-2-3-5-22-9/h7,9H,2-6H2,1H3,(H2,15,17,18)
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n/an/a 13.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390308
PNG
(CHEMBL2070592)
Show SMILES Nc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C10H11F3N6O/c11-10(12,13)9-15-7(14)6-8(16-9)19(18-17-6)4-5-2-1-3-20-5/h5H,1-4H2,(H2,14,15,16)/t5-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390309
PNG
(CHEMBL2070591)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C11H13F3N6O/c12-11(13,14)10-16-8(15)7-9(17-10)20(19-18-7)5-6-3-1-2-4-21-6/h6H,1-5H2,(H2,15,16,17)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390371
PNG
(CHEMBL2070912)
Show SMILES Nc1nc(COc2cccc(F)c2)nc2n(CC3CCCO3)nnc12
Show InChI InChI=1S/C16H17FN6O2/c17-10-3-1-4-11(7-10)25-9-13-19-15(18)14-16(20-13)23(22-21-14)8-12-5-2-6-24-12/h1,3-4,7,12H,2,5-6,8-9H2,(H2,18,19,20)
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n/an/a 17.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390339
PNG
(CHEMBL2070769)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)-c1cccs1
Show InChI InChI=1S/C14H16N6OS/c15-12-11-14(17-13(16-12)10-5-3-7-22-10)20(19-18-11)8-9-4-1-2-6-21-9/h3,5,7,9H,1-2,4,6,8H2,(H2,15,16,17)
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n/an/a 17.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390378
PNG
(CHEMBL2070919)
Show SMILES Nc1nc(nc2n(Cc3ccc4OCCc4c3)nnc12)C1CC1
Show InChI InChI=1S/C16H16N6O/c17-14-13-16(19-15(18-14)10-2-3-10)22(21-20-13)8-9-1-4-12-11(7-9)5-6-23-12/h1,4,7,10H,2-3,5-6,8H2,(H2,17,18,19)
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n/an/a 17.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390363
PNG
(CHEMBL2070932)
Show SMILES Nc1nc(nc2n(Cc3ccc4OCCOc4c3)nnc12)C1CC1
Show InChI InChI=1S/C16H16N6O2/c17-14-13-16(19-15(18-14)10-2-3-10)22(21-20-13)8-9-1-4-11-12(7-9)24-6-5-23-11/h1,4,7,10H,2-3,5-6,8H2,(H2,17,18,19)
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n/an/a 17.7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390336
PNG
(CHEMBL2070737)
Show SMILES Cc1nc(N)c2nnn(C[C@H]3CN(Cc4cc(F)cc(F)c4)CCO3)c2n1
Show InChI InChI=1S/C17H19F2N7O/c1-10-21-16(20)15-17(22-10)26(24-23-15)9-14-8-25(2-3-27-14)7-11-4-12(18)6-13(19)5-11/h4-6,14H,2-3,7-9H2,1H3,(H2,20,21,22)/t14-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390364
PNG
(CHEMBL2070933)
Show SMILES CC(C)(C)OC(=O)N1CCCCC1Cn1nnc2c(N)nc(nc12)C1CC1
Show InChI InChI=1S/C18H27N7O2/c1-18(2,3)27-17(26)24-9-5-4-6-12(24)10-25-16-13(22-23-25)14(19)20-15(21-16)11-7-8-11/h11-12H,4-10H2,1-3H3,(H2,19,20,21)
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n/an/a 21.4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390343
PNG
(CHEMBL2070773)
Show SMILES CCc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C12H18N6O/c1-2-9-14-11(13)10-12(15-9)18(17-16-10)7-8-5-3-4-6-19-8/h8H,2-7H2,1H3,(H2,13,14,15)
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n/an/a 21.6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390338
PNG
(CHEMBL2070734)
Show SMILES Nc1nc(nc2n(C[C@H]3CN(Cc4ncccn4)CCO3)nnc12)C1CC1
Show InChI InChI=1S/C17H21N9O/c18-15-14-17(22-16(21-15)11-2-3-11)26(24-23-14)9-12-8-25(6-7-27-12)10-13-19-4-1-5-20-13/h1,4-5,11-12H,2-3,6-10H2,(H2,18,21,22)/t12-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390329
PNG
(CHEMBL2070729)
Show SMILES Cc1ccnc(n1)N1CCCC(Cn2nnc3c(N)nc(nc23)C2CC2)C1
Show InChI InChI=1S/C18H23N9/c1-11-6-7-20-18(21-11)26-8-2-3-12(9-26)10-27-17-14(24-25-27)15(19)22-16(23-17)13-4-5-13/h6-7,12-13H,2-5,8-10H2,1H3,(H2,19,22,23)
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390320
PNG
(CHEMBL2070600)
Show SMILES Nc1nc(nc2n(C[C@H]3CCCO3)nnc12)C1CC1
Show InChI InChI=1S/C12H16N6O/c13-10-9-12(15-11(14-10)7-3-4-7)18(17-16-9)6-8-2-1-5-19-8/h7-8H,1-6H2,(H2,13,14,15)/t8-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390375
PNG
(CHEMBL2070916)
Show SMILES Cc1ccn2cc(Cn3nnc4c(N)nc(nc34)C3CC3)nc2c1
Show InChI InChI=1S/C16H16N8/c1-9-4-5-23-7-11(18-12(23)6-9)8-24-16-13(21-22-24)14(17)19-15(20-16)10-2-3-10/h4-7,10H,2-3,8H2,1H3,(H2,17,19,20)
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n/an/a 25.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390384
PNG
(CHEMBL2070925)
Show SMILES CN1Cc2ccccc2CC1Cn1nnc2c(N)nc(nc12)C1CC1
Show InChI InChI=1S/C18H21N7/c1-24-9-13-5-3-2-4-12(13)8-14(24)10-25-18-15(22-23-25)16(19)20-17(21-18)11-6-7-11/h2-5,11,14H,6-10H2,1H3,(H2,19,20,21)
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n/an/a 31.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390379
PNG
(CHEMBL2070920)
Show SMILES CC(c1ccc2[nH]ccc2c1)n1nnc2c(N)nc(nc12)C1CC1
Show InChI InChI=1S/C17H17N7/c1-9(11-4-5-13-12(8-11)6-7-19-13)24-17-14(22-23-24)15(18)20-16(21-17)10-2-3-10/h4-10,19H,2-3H2,1H3,(H2,18,20,21)
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n/an/a 31.7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390358
PNG
(CHEMBL2070927)
Show SMILES Cc1cn2cc(Cn3nnc4c(N)nc(nc34)C3CC3)nc2s1
Show InChI InChI=1S/C14H14N8S/c1-7-4-21-5-9(16-14(21)23-7)6-22-13-10(19-20-22)11(15)17-12(18-13)8-2-3-8/h4-5,8H,2-3,6H2,1H3,(H2,15,17,18)
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n/an/a 38.8n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390306
PNG
(CHEMBL2070768)
Show SMILES CCCc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C13H20N6O/c1-2-5-10-15-12(14)11-13(16-10)19(18-17-11)8-9-6-3-4-7-20-9/h9H,2-8H2,1H3,(H2,14,15,16)
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n/an/a 39.2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390331
PNG
(CHEMBL2070731)
Show SMILES Nc1nc(nc2n(CC3CN(Cc4ccccc4)CCO3)nnc12)C1CC1
Show InChI InChI=1S/C19H23N7O/c20-17-16-19(22-18(21-17)14-6-7-14)26(24-23-16)12-15-11-25(8-9-27-15)10-13-4-2-1-3-5-13/h1-5,14-15H,6-12H2,(H2,20,21,22)
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n/an/a 41n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390381
PNG
(CHEMBL2070922)
Show SMILES Nc1nc(nc2n(Cc3nc4ccccc4c(=O)[nH]3)nnc12)C1CC1
Show InChI InChI=1S/C16H14N8O/c17-13-12-15(21-14(20-13)8-5-6-8)24(23-22-12)7-11-18-10-4-2-1-3-9(10)16(25)19-11/h1-4,8H,5-7H2,(H2,17,20,21)(H,18,19,25)
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n/an/a 43.9n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390312
PNG
(CHEMBL2070594)
Show SMILES Cc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C11H16N6O/c1-7-13-10(12)9-11(14-7)17(16-15-9)6-8-4-2-3-5-18-8/h8H,2-6H2,1H3,(H2,12,13,14)
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n/an/a 45n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390357
PNG
(CHEMBL2070926)
Show SMILES CC(Cc1cccc(C)n1)n1nnc2c(N)nc(nc12)C1CC1
Show InChI InChI=1S/C16H19N7/c1-9-4-3-5-12(18-9)8-10(2)23-16-13(21-22-23)14(17)19-15(20-16)11-6-7-11/h3-5,10-11H,6-8H2,1-2H3,(H2,17,19,20)
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n/an/a 48.4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390380
PNG
(CHEMBL2070921)
Show SMILES Nc1nc(nc2n(Cc3cnn(n3)-c3ccccc3)nnc12)C1CC1
Show InChI InChI=1S/C16H15N9/c17-14-13-16(20-15(19-14)10-6-7-10)24(23-21-13)9-11-8-18-25(22-11)12-4-2-1-3-5-12/h1-5,8,10H,6-7,9H2,(H2,17,19,20)
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n/an/a 52.4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390365
PNG
(CHEMBL2070934)
Show SMILES Cc1cccn2cc(Cn3nnc4c(N)nc(nc34)C3CC3)nc12
Show InChI InChI=1S/C16H16N8/c1-9-3-2-6-23-7-11(18-15(9)23)8-24-16-12(21-22-24)13(17)19-14(20-16)10-4-5-10/h2-3,6-7,10H,4-5,8H2,1H3,(H2,17,19,20)
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n/an/a 53.8n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390376
PNG
(CHEMBL2070917)
Show SMILES Nc1nc(nc2n(Cc3nnc([nH]3)-c3ccccc3)nnc12)C1CC1
Show InChI InChI=1S/C16H15N9/c17-13-12-16(20-14(19-13)10-6-7-10)25(24-22-12)8-11-18-15(23-21-11)9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,17,19,20)(H,18,21,23)
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n/an/a 55.1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390350
PNG
(CHEMBL2070899)
Show SMILES Nc1nc(Cc2ccccc2)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C17H20N6O/c18-16-15-17(20-14(19-16)10-12-6-2-1-3-7-12)23(22-21-15)11-13-8-4-5-9-24-13/h1-3,6-7,13H,4-5,8-11H2,(H2,18,19,20)
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n/an/a 61.2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390340
PNG
(CHEMBL2070770)
Show SMILES COC(=O)Cc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C13H18N6O3/c1-21-10(20)6-9-15-12(14)11-13(16-9)19(18-17-11)7-8-4-2-3-5-22-8/h8H,2-7H2,1H3,(H2,14,15,16)
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n/an/a 70.7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390349
PNG
(CHEMBL2070898)
Show SMILES CC(C)CCc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C15H24N6O/c1-10(2)6-7-12-17-14(16)13-15(18-12)21(20-19-13)9-11-5-3-4-8-22-11/h10-11H,3-9H2,1-2H3,(H2,16,17,18)
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n/an/a 72.7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390382
PNG
(CHEMBL2070923)
Show SMILES C[C@@H](C1CCCCC1)n1nnc2c(N)nc(nc12)C1CC1
Show InChI InChI=1S/C15H22N6/c1-9(10-5-3-2-4-6-10)21-15-12(19-20-21)13(16)17-14(18-15)11-7-8-11/h9-11H,2-8H2,1H3,(H2,16,17,18)/t9-/m0/s1
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n/an/a 74.6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390356
PNG
(CHEMBL2070906)
Show SMILES Nc1nc(CC(O)=O)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C12H16N6O3/c13-11-10-12(15-8(14-11)5-9(19)20)18(17-16-10)6-7-3-1-2-4-21-7/h7H,1-6H2,(H,19,20)(H2,13,14,15)
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n/an/a 77.4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390360
PNG
(CHEMBL2070929)
Show SMILES Nc1nc(nc2n(Cc3ccc(cc3)C(F)(F)F)nnc12)C1CC1
Show InChI InChI=1S/C15H13F3N6/c16-15(17,18)10-5-1-8(2-6-10)7-24-14-11(22-23-24)12(19)20-13(21-14)9-3-4-9/h1-2,5-6,9H,3-4,7H2,(H2,19,20,21)
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n/an/a 78.4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390377
PNG
(CHEMBL2070918)
Show SMILES Cc1ncsc1CCn1nnc2c(N)nc(nc12)C1CC1
Show InChI InChI=1S/C13H15N7S/c1-7-9(21-6-15-7)4-5-20-13-10(18-19-20)11(14)16-12(17-13)8-2-3-8/h6,8H,2-5H2,1H3,(H2,14,16,17)
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n/an/a 79.4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390315
PNG
(CHEMBL2070597)
Show SMILES CC(C)S(=O)(=O)Cc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C14H22N6O3S/c1-9(2)24(21,22)8-11-16-13(15)12-14(17-11)20(19-18-12)7-10-5-3-4-6-23-10/h9-10H,3-8H2,1-2H3,(H2,15,16,17)
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n/an/a 84n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390341
PNG
(CHEMBL2070771)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)-c1ccco1
Show InChI InChI=1S/C14H16N6O2/c15-12-11-14(17-13(16-12)10-5-3-7-22-10)20(19-18-11)8-9-4-1-2-6-21-9/h3,5,7,9H,1-2,4,6,8H2,(H2,15,16,17)
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n/an/a 84.4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390323
PNG
(CHEMBL2070603)
Show SMILES Nc1nc(nc2n(Cc3ccc(Cl)cc3)nnc12)C1CC1
Show InChI InChI=1S/C14H13ClN6/c15-10-5-1-8(2-6-10)7-21-14-11(19-20-21)12(16)17-13(18-14)9-3-4-9/h1-2,5-6,9H,3-4,7H2,(H2,16,17,18)
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n/an/a 86n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390345
PNG
(CHEMBL2070775)
Show SMILES Nc1nc(Cc2cccs2)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C15H18N6OS/c16-14-13-15(18-12(17-14)8-11-5-3-7-23-11)21(20-19-13)9-10-4-1-2-6-22-10/h3,5,7,10H,1-2,4,6,8-9H2,(H2,16,17,18)
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n/an/a 87.2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390307
PNG
(CHEMBL2070589)
Show SMILES CC(C)c1nc(NC(CN2CCCCC2)c2ccccc2)c2nnn(Cc3ccccc3)c2n1
Show InChI InChI=1S/C27H33N7/c1-20(2)25-29-26(24-27(30-25)34(32-31-24)18-21-12-6-3-7-13-21)28-23(22-14-8-4-9-15-22)19-33-16-10-5-11-17-33/h3-4,6-9,12-15,20,23H,5,10-11,16-19H2,1-2H3,(H,28,29,30)
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n/an/a 89n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390304
PNG
(CHEMBL2070766)
Show SMILES COc1ccc(Cn2nnc3c(N)nc(nc23)C#N)cc1
Show InChI InChI=1S/C13H11N7O/c1-21-9-4-2-8(3-5-9)7-20-13-11(18-19-20)12(15)16-10(6-14)17-13/h2-5H,7H2,1H3,(H2,15,16,17)
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n/an/a 90.7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390314
PNG
(CHEMBL2070596)
Show SMILES COCc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C12H18N6O2/c1-19-7-9-14-11(13)10-12(15-9)18(17-16-10)6-8-4-2-3-5-20-8/h8H,2-7H2,1H3,(H2,13,14,15)
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n/an/a 91n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390327
PNG
(CHEMBL2070609)
Show SMILES CCc1cnc(nc1)N1CC[C@@H](Cn2nnc3c(N)nc(nc23)C2CC2)C1
Show InChI InChI=1S/C18H23N9/c1-2-11-7-20-18(21-8-11)26-6-5-12(9-26)10-27-17-14(24-25-27)15(19)22-16(23-17)13-3-4-13/h7-8,12-13H,2-6,9-10H2,1H3,(H2,19,22,23)/t12-/m1/s1
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n/an/a 92n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390326
PNG
(CHEMBL2070606)
Show SMILES CCc1nc(Cn2nnc3c(N)nc(nc23)C2CC2)cs1
Show InChI InChI=1S/C13H15N7S/c1-2-9-15-8(6-21-9)5-20-13-10(18-19-20)11(14)16-12(17-13)7-3-4-7/h6-7H,2-5H2,1H3,(H2,14,16,17)
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n/an/a 93n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390354
PNG
(CHEMBL2070903)
Show SMILES CC(=O)OCc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C13H18N6O3/c1-8(20)22-7-10-15-12(14)11-13(16-10)19(18-17-11)6-9-4-2-3-5-21-9/h9H,2-7H2,1H3,(H2,14,15,16)
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n/an/a 125n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390325
PNG
(CHEMBL2070605)
Show SMILES CC(C)n1cc(Cn2nnc3c(N)nc(nc23)C2CC2)cn1
Show InChI InChI=1S/C14H18N8/c1-8(2)21-6-9(5-16-21)7-22-14-11(19-20-22)12(15)17-13(18-14)10-3-4-10/h5-6,8,10H,3-4,7H2,1-2H3,(H2,15,17,18)
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n/an/a 136n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390383
PNG
(CHEMBL2070924)
Show SMILES Nc1nc(nc2n(CCSCc3ccco3)nnc12)C1CC1
Show InChI InChI=1S/C14H16N6OS/c15-12-11-14(17-13(16-12)9-3-4-9)20(19-18-11)5-7-22-8-10-2-1-6-21-10/h1-2,6,9H,3-5,7-8H2,(H2,15,16,17)
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n/an/a 136n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390321
PNG
(CHEMBL2070601)
Show SMILES Nc1nc(nc2n(CC3CCCOC3)nnc12)C1CC1
Show InChI InChI=1S/C13H18N6O/c14-11-10-13(16-12(15-11)9-3-4-9)19(18-17-10)6-8-2-1-5-20-7-8/h8-9H,1-7H2,(H2,14,15,16)
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n/an/a 150n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390316
PNG
(CHEMBL2070598)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)-c1ccccc1
Show InChI InChI=1S/C16H18N6O/c17-14-13-16(19-15(18-14)11-6-2-1-3-7-11)22(21-20-13)10-12-8-4-5-9-23-12/h1-3,6-7,12H,4-5,8-10H2,(H2,17,18,19)
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n/an/a 160n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390353
PNG
(CHEMBL2070902)
Show SMILES CSCc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C12H18N6OS/c1-20-7-9-14-11(13)10-12(15-9)18(17-16-10)6-8-4-2-3-5-19-8/h8H,2-7H2,1H3,(H2,13,14,15)
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n/an/a 177n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390369
PNG
(CHEMBL2070909)
Show SMILES Nc1nc(CC#N)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C12H15N7O/c13-5-4-9-15-11(14)10-12(16-9)19(18-17-10)7-8-3-1-2-6-20-8/h8H,1-4,6-7H2,(H2,14,15,16)
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n/an/a 182n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390351
PNG
(CHEMBL2070900)
Show SMILES CC(C)Cc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C14H22N6O/c1-9(2)7-11-16-13(15)12-14(17-11)20(19-18-12)8-10-5-3-4-6-21-10/h9-10H,3-8H2,1-2H3,(H2,15,16,17)
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n/an/a 186n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390328
PNG
(CHEMBL2070610)
Show SMILES Nc1nc(nc2n(C[C@@H]3CCN(Cc4nccs4)C3)nnc12)C1CC1
Show InChI InChI=1S/C16H20N8S/c17-14-13-16(20-15(19-14)11-1-2-11)24(22-21-13)8-10-3-5-23(7-10)9-12-18-4-6-25-12/h4,6,10-11H,1-3,5,7-9H2,(H2,17,19,20)/t10-/m1/s1
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n/an/a 206n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390362
PNG
(CHEMBL2070931)
Show SMILES Nc1nc(nc2n(CC3(CCOCC3)c3ccccc3)nnc12)C1CC1
Show InChI InChI=1S/C19H22N6O/c20-16-15-18(22-17(21-16)13-6-7-13)25(24-23-15)12-19(8-10-26-11-9-19)14-4-2-1-3-5-14/h1-5,13H,6-12H2,(H2,20,21,22)
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n/an/a 225n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390348
PNG
(CHEMBL2070897)
Show SMILES CCCCc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C14H22N6O/c1-2-3-7-11-16-13(15)12-14(17-11)20(19-18-12)9-10-6-4-5-8-21-10/h10H,2-9H2,1H3,(H2,15,16,17)
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n/an/a 228n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390317
PNG
(CHEMBL2070599)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)C1CCCCC1
Show InChI InChI=1S/C16H24N6O/c17-14-13-16(19-15(18-14)11-6-2-1-3-7-11)22(21-20-13)10-12-8-4-5-9-23-12/h11-12H,1-10H2,(H2,17,18,19)
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n/an/a 243n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390344
PNG
(CHEMBL2070774)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)C1CCC1
Show InChI InChI=1S/C14H20N6O/c15-12-11-14(17-13(16-12)9-4-3-5-9)20(19-18-11)8-10-6-1-2-7-21-10/h9-10H,1-8H2,(H2,15,16,17)
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n/an/a 247n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390385
PNG
(CHEMBL2070911)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)C1CCCO1
Show InChI InChI=1S/C14H20N6O2/c15-12-11-14(17-13(16-12)10-5-3-7-22-10)20(19-18-11)8-9-4-1-2-6-21-9/h9-10H,1-8H2,(H2,15,16,17)
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n/an/a 250n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390305
PNG
(CHEMBL2070767)
Show SMILES COc1ccc(Cn2nnc3c(N)nc(nc23)C(N)=O)cc1
Show InChI InChI=1S/C13H13N7O2/c1-22-8-4-2-7(3-5-8)6-20-13-9(18-19-20)10(14)16-12(17-13)11(15)21/h2-5H,6H2,1H3,(H2,15,21)(H2,14,16,17)
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n/an/a 252n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390346
PNG
(CHEMBL2070895)
Show SMILES Nc1nc(Cc2ccsc2)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C15H18N6OS/c16-14-13-15(18-12(17-14)7-10-4-6-23-9-10)21(20-19-13)8-11-3-1-2-5-22-11/h4,6,9,11H,1-3,5,7-8H2,(H2,16,17,18)
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n/an/a 254n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390372
PNG
(CHEMBL2070913)
Show SMILES COCc1nc(N)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C11H16N6O2/c1-18-6-8-13-10(12)9-11(14-8)17(16-15-9)5-7-3-2-4-19-7/h7H,2-6H2,1H3,(H2,12,13,14)/t7-/m1/s1
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n/an/a 281n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390347
PNG
(CHEMBL2070896)
Show SMILES Nc1nc(CC2CC2)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C14H20N6O/c15-13-12-14(17-11(16-13)7-9-4-5-9)20(19-18-12)8-10-3-1-2-6-21-10/h9-10H,1-8H2,(H2,15,16,17)
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n/an/a 319n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390342
PNG
(CHEMBL2070772)
Show SMILES Nc1nc(nc2n(CC3CCCCO3)nnc12)-c1cccnc1
Show InChI InChI=1S/C15H17N7O/c16-13-12-15(19-14(18-13)10-4-3-6-17-8-10)22(21-20-12)9-11-5-1-2-7-23-11/h3-4,6,8,11H,1-2,5,7,9H2,(H2,16,18,19)
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n/an/a 331n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390368
PNG
(CHEMBL2070908)
Show SMILES Cc1cc(no1)-c1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C14H17N7O2/c1-8-6-10(19-23-8)13-16-12(15)11-14(17-13)21(20-18-11)7-9-4-2-3-5-22-9/h6,9H,2-5,7H2,1H3,(H2,15,16,17)
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n/an/a 388n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390277
PNG
(CHEMBL2070739)
Show SMILES FC(F)(F)c1nc(NCc2cccnc2)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C17H18F3N7O/c18-17(19,20)16-23-14(22-9-11-4-3-6-21-8-11)13-15(24-16)27(26-25-13)10-12-5-1-2-7-28-12/h3-4,6,8,12H,1-2,5,7,9-10H2,(H,22,23,24)
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n/an/a>420n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390361
PNG
(CHEMBL2070930)
Show SMILES CCCCN1CC(Cn2nnc3c(N)nc(nc23)C2CC2)OCC1=O
Show InChI InChI=1S/C16H23N7O2/c1-2-3-6-22-7-11(25-9-12(22)24)8-23-16-13(20-21-23)14(17)18-15(19-16)10-4-5-10/h10-11H,2-9H2,1H3,(H2,17,18,19)
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n/an/a 455n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390359
PNG
(CHEMBL2070928)
Show SMILES Cc1ccn2cc(Cn3nnc4c(N)nc(nc34)C3CC3)nc2n1
Show InChI InChI=1S/C15H15N9/c1-8-4-5-23-6-10(18-15(23)17-8)7-24-14-11(21-22-24)12(16)19-13(20-14)9-2-3-9/h4-6,9H,2-3,7H2,1H3,(H2,16,19,20)
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n/an/a 458n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390386
PNG
(CHEMBL2070905)
Show SMILES Nc1nc(Cn2ccnc2)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C14H18N8O/c15-13-12-14(18-11(17-13)8-21-5-4-16-9-21)22(20-19-12)7-10-3-1-2-6-23-10/h4-5,9-10H,1-3,6-8H2,(H2,15,17,18)
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n/an/a 516n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390374
PNG
(CHEMBL2070915)
Show SMILES Cn1cc(CCn2nnc3c(N)nc(nc23)C2CC2)cn1
Show InChI InChI=1S/C13H16N8/c1-20-7-8(6-15-20)4-5-21-13-10(18-19-21)11(14)16-12(17-13)9-2-3-9/h6-7,9H,2-5H2,1H3,(H2,14,16,17)
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n/an/a 551n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390310
PNG
(CHEMBL2070590)
Show SMILES CN(C)CCNc1nc(nc2n(CC3CCCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C15H22F3N7O/c1-24(2)7-6-19-12-11-13(21-14(20-12)15(16,17)18)25(23-22-11)9-10-5-3-4-8-26-10/h10H,3-9H2,1-2H3,(H,19,20,21)
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n/an/a 703n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390355
PNG
(CHEMBL2070904)
Show SMILES Nc1nc(CO)nc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C11H16N6O2/c12-10-9-11(14-8(6-18)13-10)17(16-15-9)5-7-3-1-2-4-19-7/h7,18H,1-6H2,(H2,12,13,14)
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n/an/a 773n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390322
PNG
(CHEMBL2070602)
Show SMILES Nc1nc(nc2n(CC3CCOCC3)nnc12)C1CC1
Show InChI InChI=1S/C13H18N6O/c14-11-10-13(16-12(15-11)9-1-2-9)19(18-17-10)7-8-3-5-20-6-4-8/h8-9H,1-7H2,(H2,14,15,16)
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n/an/a 925n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390370
PNG
(CHEMBL2070910)
Show SMILES NC(=O)Cc1nc(N)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C12H17N7O2/c13-8(20)5-9-15-11(14)10-12(16-9)19(18-17-10)6-7-3-1-2-4-21-7/h7H,1-6H2,(H2,13,20)(H2,14,15,16)
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n/an/a 1.11E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390311
PNG
(CHEMBL2070593)
Show SMILES Nc1ncnc2n(CC3CCCCO3)nnc12
Show InChI InChI=1S/C10H14N6O/c11-9-8-10(13-6-12-9)16(15-14-8)5-7-3-1-2-4-17-7/h6-7H,1-5H2,(H2,11,12,13)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390318
PNG
(CHEMBL2070607)
Show SMILES Nc1nc(nc2n(C[C@H]3CCCO3)cnc12)C1CC1
Show InChI InChI=1S/C13H17N5O/c14-11-10-13(17-12(16-11)8-3-4-8)18(7-15-10)6-9-2-1-5-19-9/h7-9H,1-6H2,(H2,14,16,17)/t9-/m1/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390292
PNG
(CHEMBL2070753)
Show SMILES FC(F)(F)c1nc(NCc2ccncc2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C16H16F3N7O/c17-16(18,19)15-22-13(21-8-10-3-5-20-6-4-10)12-14(23-15)26(25-24-12)9-11-2-1-7-27-11/h3-6,11H,1-2,7-9H2,(H,21,22,23)/t11-/m1/s1
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n/an/a 2.77E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390330
PNG
(CHEMBL2070730)
Show SMILES Nc1nc(nc2n(CC3CCCN(Cc4ccccc4)C3)nnc12)C1CC1
Show InChI InChI=1S/C20H25N7/c21-18-17-20(23-19(22-18)16-8-9-16)27(25-24-17)13-15-7-4-10-26(12-15)11-14-5-2-1-3-6-14/h1-3,5-6,15-16H,4,7-13H2,(H2,21,22,23)
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n/an/a 3.62E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390276
PNG
(CHEMBL2070738)
Show SMILES FC(F)(F)c1nc(NCC2CCCO2)c2nnn(CC3CCCCO3)c2n1
Show InChI InChI=1S/C16H21F3N6O2/c17-16(18,19)15-21-13(20-8-10-5-3-7-26-10)12-14(22-15)25(24-23-12)9-11-4-1-2-6-27-11/h10-11H,1-9H2,(H,20,21,22)
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n/an/a 4.03E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390288
PNG
(CHEMBL2070749)
Show SMILES Cc1ccc(CNc2nc(nc3n(C[C@H]4CCCO4)nnc23)C(F)(F)F)o1
Show InChI InChI=1S/C16H17F3N6O2/c1-9-4-5-10(27-9)7-20-13-12-14(22-15(21-13)16(17,18)19)25(24-23-12)8-11-3-2-6-26-11/h4-5,11H,2-3,6-8H2,1H3,(H,20,21,22)/t11-/m1/s1
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n/an/a 5.39E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390287
PNG
(CHEMBL2070748)
Show SMILES FC(F)(F)c1nc(NCCc2ccco2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C16H17F3N6O2/c17-16(18,19)15-21-13(20-6-5-10-3-1-7-26-10)12-14(22-15)25(24-23-12)9-11-4-2-8-27-11/h1,3,7,11H,2,4-6,8-9H2,(H,20,21,22)/t11-/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390290
PNG
(CHEMBL2070751)
Show SMILES Fc1cccc(CCNc2nc(nc3n(C[C@H]4CCCO4)nnc23)C(F)(F)F)c1
Show InChI InChI=1S/C18H18F4N6O/c19-12-4-1-3-11(9-12)6-7-23-15-14-16(25-17(24-15)18(20,21)22)28(27-26-14)10-13-5-2-8-29-13/h1,3-4,9,13H,2,5-8,10H2,(H,23,24,25)/t13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390319
PNG
(CHEMBL2070608)
Show SMILES Nc1nc(nc2n(CC3CCCO3)ncc12)C1CC1
Show InChI InChI=1S/C13H17N5O/c14-11-10-6-15-18(7-9-2-1-5-19-9)13(10)17-12(16-11)8-3-4-8/h6,8-9H,1-5,7H2,(H2,14,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390291
PNG
(CHEMBL2070752)
Show SMILES COCC(C)Nc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C14H19F3N6O2/c1-8(7-24-2)18-11-10-12(20-13(19-11)14(15,16)17)23(22-21-10)6-9-4-3-5-25-9/h8-9H,3-7H2,1-2H3,(H,18,19,20)/t8?,9-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390337
PNG
(CHEMBL2070758)
Show SMILES CNc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C11H13F3N6O/c1-15-8-7-9(17-10(16-8)11(12,13)14)20(19-18-7)5-6-3-2-4-21-6/h6H,2-5H2,1H3,(H,15,16,17)/t6-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390283
PNG
(CHEMBL2070745)
Show SMILES FC(F)(F)c1nc(NC2CCCCC2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C16H21F3N6O/c17-16(18,19)15-21-13(20-10-5-2-1-3-6-10)12-14(22-15)25(24-23-12)9-11-7-4-8-26-11/h10-11H,1-9H2,(H,20,21,22)/t11-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390299
PNG
(CHEMBL2070761)
Show SMILES CN(C)CCCNc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C15H22F3N7O/c1-24(2)7-4-6-19-12-11-13(21-14(20-12)15(16,17)18)25(23-22-11)9-10-5-3-8-26-10/h10H,3-9H2,1-2H3,(H,19,20,21)/t10-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390302
PNG
(CHEMBL2070764)
Show SMILES FC(F)(F)c1nc(NCCCc2ccccc2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C19H21F3N6O/c20-19(21,22)18-24-16(23-10-4-8-13-6-2-1-3-7-13)15-17(25-18)28(27-26-15)12-14-9-5-11-29-14/h1-3,6-7,14H,4-5,8-12H2,(H,23,24,25)/t14-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390278
PNG
(CHEMBL2070740)
Show SMILES CN(C)c1nc(C)nc2n(C[C@H]3CCCO3)nnc12
Show InChI InChI=1S/C12H18N6O/c1-8-13-11(17(2)3)10-12(14-8)18(16-15-10)7-9-5-4-6-19-9/h9H,4-7H2,1-3H3/t9-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390280
PNG
(CHEMBL2070742)
Show SMILES CCc1ccc(CNc2nc(nc3n(C[C@H]4CCCO4)nnc23)C(F)(F)F)nc1
Show InChI InChI=1S/C18H20F3N7O/c1-2-11-5-6-12(22-8-11)9-23-15-14-16(25-17(24-15)18(19,20)21)28(27-26-14)10-13-4-3-7-29-13/h5-6,8,13H,2-4,7,9-10H2,1H3,(H,23,24,25)/t13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390285
PNG
(CHEMBL2070747)
Show SMILES Cc1cnc(CNc2nc(nc3n(C[C@H]4CCCO4)nnc23)C(F)(F)F)cn1
Show InChI InChI=1S/C16H17F3N8O/c1-9-5-21-10(6-20-9)7-22-13-12-14(24-15(23-13)16(17,18)19)27(26-25-12)8-11-3-2-4-28-11/h5-6,11H,2-4,7-8H2,1H3,(H,22,23,24)/t11-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390303
PNG
(CHEMBL2070765)
Show SMILES FC(F)(F)c1nc(NCCC2CCCC2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C17H23F3N6O/c18-17(19,20)16-22-14(21-8-7-11-4-1-2-5-11)13-15(23-16)26(25-24-13)10-12-6-3-9-27-12/h11-12H,1-10H2,(H,21,22,23)/t12-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390279
PNG
(CHEMBL2070741)
Show SMILES CC(C)CCNc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C15H21F3N6O/c1-9(2)5-6-19-12-11-13(21-14(20-12)15(16,17)18)24(23-22-11)8-10-4-3-7-25-10/h9-10H,3-8H2,1-2H3,(H,19,20,21)/t10-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390300
PNG
(CHEMBL2070762)
Show SMILES COCCCNc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C14H19F3N6O2/c1-24-6-3-5-18-11-10-12(20-13(19-11)14(15,16)17)23(22-21-10)8-9-4-2-7-25-9/h9H,2-8H2,1H3,(H,18,19,20)/t9-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390282
PNG
(CHEMBL2070744)
Show SMILES FC(F)(F)c1nc(NC2CCSCC2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C15H19F3N6OS/c16-15(17,18)14-20-12(19-9-3-6-26-7-4-9)11-13(21-14)24(23-22-11)8-10-2-1-5-25-10/h9-10H,1-8H2,(H,19,20,21)/t10-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390293
PNG
(CHEMBL2070754)
Show SMILES FC(F)(F)c1nc(NC2Cc3ccccc3C2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C19H19F3N6O/c20-19(21,22)18-24-16(23-13-8-11-4-1-2-5-12(11)9-13)15-17(25-18)28(27-26-15)10-14-6-3-7-29-14/h1-2,4-5,13-14H,3,6-10H2,(H,23,24,25)/t14-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390295
PNG
(CHEMBL2070756)
Show SMILES COc1ccc(CNc2nc(nc3n(C[C@H]4CCCO4)nnc23)C(F)(F)F)cc1
Show InChI InChI=1S/C18H19F3N6O2/c1-28-12-6-4-11(5-7-12)9-22-15-14-16(24-17(23-15)18(19,20)21)27(26-25-14)10-13-3-2-8-29-13/h4-7,13H,2-3,8-10H2,1H3,(H,22,23,24)/t13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390298
PNG
(CHEMBL2070760)
Show SMILES FC(F)(F)c1nc(NCC2CCCO2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C15H19F3N6O2/c16-15(17,18)14-20-12(19-7-9-3-1-5-25-9)11-13(21-14)24(23-22-11)8-10-4-2-6-26-10/h9-10H,1-8H2,(H,19,20,21)/t9?,10-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390294
PNG
(CHEMBL2070755)
Show SMILES FC(F)(F)c1nc(NCCc2ccncc2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C17H18F3N7O/c18-17(19,20)16-23-14(22-8-5-11-3-6-21-7-4-11)13-15(24-16)27(26-25-13)10-12-2-1-9-28-12/h3-4,6-7,12H,1-2,5,8-10H2,(H,22,23,24)/t12-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390286
PNG
(CHEMBL2069322)
Show SMILES CN(C)CCNc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C14H20F3N7O/c1-23(2)6-5-18-11-10-12(20-13(19-11)14(15,16)17)24(22-21-10)8-9-4-3-7-25-9/h9H,3-8H2,1-2H3,(H,18,19,20)/t9-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390297
PNG
(CHEMBL2070759)
Show SMILES FC(F)(F)c1nc(NC2CC2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C13H15F3N6O/c14-13(15,16)12-18-10(17-7-3-4-7)9-11(19-12)22(21-20-9)6-8-2-1-5-23-8/h7-8H,1-6H2,(H,17,18,19)/t8-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390289
PNG
(CHEMBL2070750)
Show SMILES Cc1ccc(CNc2nc(nc3n(C[C@H]4CCCO4)nnc23)C(F)(F)F)cc1
Show InChI InChI=1S/C18H19F3N6O/c1-11-4-6-12(7-5-11)9-22-15-14-16(24-17(23-15)18(19,20)21)27(26-25-14)10-13-3-2-8-28-13/h4-7,13H,2-3,8-10H2,1H3,(H,22,23,24)/t13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390296
PNG
(CHEMBL2070757)
Show SMILES FC(F)(F)c1nc(NC2CCCCCC2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C17H23F3N6O/c18-17(19,20)16-22-14(21-11-6-3-1-2-4-7-11)13-15(23-16)26(25-24-13)10-12-8-5-9-27-12/h11-12H,1-10H2,(H,21,22,23)/t12-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390301
PNG
(CHEMBL2070763)
Show SMILES COC(=O)CNc1nc(nc2n(C[C@H]3CCCO3)nnc12)C(F)(F)F
Show InChI InChI=1S/C13H15F3N6O3/c1-24-8(23)5-17-10-9-11(19-12(18-10)13(14,15)16)22(21-20-9)6-7-3-2-4-25-7/h7H,2-6H2,1H3,(H,17,18,19)/t7-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390281
PNG
(CHEMBL2070743)
Show SMILES FC(F)(F)c1nc(NCCn2cccn2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C15H17F3N8O/c16-15(17,18)14-21-12(19-5-7-25-6-2-4-20-25)11-13(22-14)26(24-23-11)9-10-3-1-8-27-10/h2,4,6,10H,1,3,5,7-9H2,(H,19,21,22)/t10-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens)
BDBM50390284
PNG
(CHEMBL2070746)
Show SMILES FC(F)(F)c1nc(NCCOc2ccccc2)c2nnn(C[C@H]3CCCO3)c2n1
Show InChI InChI=1S/C18H19F3N6O2/c19-18(20,21)17-23-15(22-8-10-29-12-5-2-1-3-6-12)14-16(24-17)27(26-25-14)11-13-7-4-9-28-13/h1-3,5-6,13H,4,7-11H2,(H,22,23,24)/t13-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE8B expressed in Sf9 insect cells


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50390334
PNG
(CHEMBL2070735)
Show SMILES Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1
Show InChI InChI=1S/C14H18N8OS/c1-9-17-13(15)12-14(18-9)22(20-19-12)7-10-6-21(3-4-23-10)8-11-16-2-5-24-11/h2,5,10H,3-4,6-8H2,1H3,(H2,15,17,18)/t10-/m1/s1
PDB
MMDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 22: 5721-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.079
BindingDB Entry DOI: 10.7270/Q2J67J0X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%