Affinity Data by PubMed id=22924757

PubMed code 22924757

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398250 (CHEMBL2177887) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.27E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398249 (CHEMBL2177864) Show SMILES CCCCCNc1oc2c(C)ncc(CO)c2c1Nc1ccccc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398256 (CHEMBL2177874) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.68E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398255 (CHEMBL2177875) Show SMILES CCCCNc1oc2c(C)ncc(CO)c2c1Nc1ccccn1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.38E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398247 (CHEMBL2177866) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	850	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398259 (CHEMBL2177870) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398260 (CHEMBL2177869) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.93E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398252 (CHEMBL2177880) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.99E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398258 (CHEMBL2177871) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.91E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398248 (CHEMBL2177865) Show SMILES CCCCCNc1oc2c(C)ncc(CO)c2c1Nc1cccc(F)c1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398251 (CHEMBL2177883) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.64E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398254 (CHEMBL2177876) Show SMILES CCCCCNc1oc2c(C)ncc(CO)c2c1Nc1ccccn1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.81E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398257 (CHEMBL2177872) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.79E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398245 (CHEMBL512901 \| CL-075) Show SMILES CCCc1nc2c(N)nc3ccccc3c2s1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398246 (CHEMBL2177867) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.37E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50398253 (CHEMBL2177878) Show SMILES CCCC(C)Nc1oc2c(C)ncc(CO)c2c1Nc1ccccn1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.01E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline pho...				J Med Chem 55: 8137-51 (2012) Article DOI: 10.1021/jm301066h BindingDB Entry DOI: 10.7270/Q21N827G
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%