Compile Data Set for Download or QSAR
maximum 50k data
Found 19 Enz. Inhib. hit(s) with all data for entry = 50042514
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50:  4nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of plasma renin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50:  25nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427039(CHEMBL2322208)
Affinity DataIC50:  90nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427041(CHEMBL2322210)
Affinity DataIC50: >100nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427042(CHEMBL2322211)
Affinity DataIC50: >100nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427038(CHEMBL2322206)
Affinity DataIC50:  500nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427037(CHEMBL2322204)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427037(CHEMBL2322204)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant renin using fluorescence-quenched (RE(EDANS)IHPFHLVIHTK(Dabcyl)R as substrate incubated for 1 hr prior to substrate a...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427036(CHEMBL2322205)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant BACE2 expressed in baculovirus-infected SF9 cells using fluorescence-quenched RE(EDANS)-EVNLDAEF-K(DABSYL)-R as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastricsin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant pepsin C expressed in Escherichia coli using fluorescence-quenched Dabcyl-E-R-Nle-F-L-S-F-P-EDANS as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427043(CHEMBL2322203)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin E expressed in Escherichia coli using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)-E-Amid as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427040(CHEMBL2322207)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant cathepsin D expressed in baculovirus-infected SF9 cells using fluorescence-quenched Ac-E-D(EDANS)-KPILFFRLG-K(Dabcyl)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427041(CHEMBL2322210)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to human recombinant renin by NMR titration analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50427042(CHEMBL2322211)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to human recombinant renin by NMR titration analysisMore data for this Ligand-Target Pair