Compile Data Set for Download or QSAR
maximum 50k data
Found 15 Enz. Inhib. hit(s) with all data for entry = 50042824
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  38nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50396981(CHEMBL2171174)
Affinity DataKi:  300nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  750nMAssay Description:Inhibition of recombinant full length human NNMT measured for 30 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  950nMAssay Description:Inhibition of DNMT1 (unknown origin) using [3H]-SAM assessed as inhibition of dsDNA methylation after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataKi:  1.15E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50396023(CHEMBL2169919)
Affinity DataIC50:  0.400nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 416 amino acid residues) using [3H]-SAM assessed as inhibition of nucleosome methylation incu...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50:  77nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 472 amino acid residues) expressed in Escherichia coli BL21 (DE3) using [3H]-SAM assessed as ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  600nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair
TargetNicotinamide N-methyltransferase(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of recombinant full length human NNMT measured for 30 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of DNMT1 (unknown origin) using [3H]-SAM assessed as inhibition of dsDNA methylation after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50431676(CHEMBL2349526)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of PRMT3 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H4 (1 to 24 amino acid residues) methylation after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50375654(CHEMBL99203 | US11633415, Compound 5-iodotubercidi...)
Affinity DataIC50:  1.82E+4nMAssay Description:Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as subst...More data for this Ligand-Target Pair