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Found 25 Enz. Inhib. hit(s) with all data for entry = 50044468
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018286(CHEMBL3290335)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018284(CHEMBL3290333)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018282(CHEBI:79045 | CHEMBL3290331)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018282(CHEBI:79045 | CHEMBL3290331)
Affinity DataIC50:  440nMAssay Description:Antagonist activity at smoothened (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018273(CHEMBL3290322)
Affinity DataIC50:  740nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018285(CHEMBL3290334)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018275(CHEMBL3290324)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018281(CHEMBL3290330)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268610(6-[(R)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperaz...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018276(CHEMBL3290325)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018271(CHEMBL3290320)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018283(CHEMBL3290332)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50158336(2-(4-octylphenethyl)-2-aminopropane-1,3-diol | 2-A...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018286(CHEMBL3290335)
Affinity DataIC50: >2.50E+4nMAssay Description:Antagonist activity at smoothened (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018279(CHEMBL3290328)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018280(CHEMBL3290329)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018272(CHEMBL3290321)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018278(CHEMBL3290327)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018277(CHEMBL3290326)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50268609(6-[(S)-4-(4-Benzylphthalazin-1-yl)-2-methylpiperaz...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269082(6-[4-(4-Benzylphthalazin-1-yl)piperazin-1-yl]nicot...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018274(CHEMBL3290323)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50158336(2-(4-octylphenethyl)-2-aminopropane-1,3-diol | 2-A...)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of S1PL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018270(CHEMBL1852164)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of S1PL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018269(CHEMBL488336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of S1PL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed