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Found 38 Enz. Inhib. hit(s) with all data for entry = 50046606
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant human Vps34 by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50380399(CHEMBL2018302 | Tubastatin A | US10227295, Compoun...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndoplasmin(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50087812(CHEMBL3426787)
Affinity DataIC50:  32nMAssay Description:Inhibition of GRP94 (unknown origin) expressed in HEK293 cells assessed as reduction of Toll-like receptor trafficking to cell membrane treated for 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121209(CHEMBL3622376)
Affinity DataIC50:  35nMAssay Description:Inhibition of JAK3 (unknown origin) after 20 mins by radiometric analysis in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  240nMAssay Description:Inhibition of HDAC3 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121211(CHEMBL3622375)
Affinity DataIC50:  260nMAssay Description:Inhibition of HDAC3 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121213(CHEMBL3622371)
Affinity DataIC50:  300nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50346862(CHEMBL1215658)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of N-terminal hexahistidine-tagged human LSD1 (1 to 852 amino acid residues) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121209(CHEMBL3622376)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of JAK2 (unknown origin) after 20 mins by radiometric analysis in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of N-terminal hexahistidine-tagged human LSD1 (1 to 852 amino acid residues) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121209(CHEMBL3622376)
Affinity DataIC50:  2.73E+3nMAssay Description:Inhibition of JAK1 (unknown origin) after 20 mins by radiometric analysis in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human MAO-B using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121209(CHEMBL3622376)
Affinity DataIC50:  5.62E+3nMAssay Description:Inhibition of TYK2 (unknown origin) after 20 mins by radiometric analysis in presence of [gamma33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human MAO-A using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kbeta by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kalpha by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kgamma by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kdelta by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human mTOR by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121213(CHEMBL3622371)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of N-terminal hexahistidine-tagged human LSD1 (1 to 852 amino acid residues) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC8 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121211(CHEMBL3622375)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC6 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121211(CHEMBL3622375)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC4 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121211(CHEMBL3622375)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC8 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121211(CHEMBL3622375)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC5 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC4 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121211(CHEMBL3622375)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC5 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121210(CHEMBL3622374)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HDAC6 in human HeLa nuclear extracts by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50:  2.30E+5nMAssay Description:Inhibition of human MAO-A using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50346862(CHEMBL1215658)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of human MAO-A using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50445336(CHEMBL1797639)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of human MAO-B using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50346862(CHEMBL1215658)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human MAO-B using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid as substrate after 60 mins by MAO-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  21nMAssay Description:Binding affinity to human CBP by ITC analysisMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM188519(SGC-CBP30)
Affinity DataKd:  32nMAssay Description:Binding affinity to human p300 by ITC analysisMore data for this Ligand-Target Pair