Compile Data Set for Download or QSAR
maximum 50k data
Found 38 Enz. Inhib. hit(s) with all data for entry = 50046401
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataKi:  8.20nMAssay Description:Competitive inhibition of CDK6/cyclin D3 (unknown origin) assessed as phosphorylation of CTRF after 50 mins by Michaelis-Menten plot analysis in pres...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6302(8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110179(CHEMBL190281)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50:  3.20nMAssay Description:Competitive inhibition of human CDK7 in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110180(CHEMBL3604462)
Affinity DataIC50:  4nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM148264(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110187(CHEMBL3604469)
Affinity DataIC50:  32nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110184(CHEMBL3604466)
Affinity DataIC50:  34nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM148264(7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)p...)
Affinity DataIC50:  39nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110179(CHEMBL190281)
Affinity DataIC50:  43nMAssay Description:Inhibition of CDK2 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataIC50:  47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110185(CHEMBL3604467)
Affinity DataIC50:  59nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110186(CHEMBL3604468)
Affinity DataIC50:  122nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113349(CHEMBL457388)
Affinity DataIC50:  140nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataIC50: <200nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataIC50: <200nMAssay Description:Inhibition of GSK3beta (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113281(AT-7519)
Affinity DataIC50: <200nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataIC50: <200nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110181(CHEMBL3604463)
Affinity DataIC50:  222nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6302(8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)
Affinity DataIC50:  230nMAssay Description:Inhibition of CDK2 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110185(CHEMBL3604467)
Affinity DataIC50:  403nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50:  439nMAssay Description:Inhibition of CDK2 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110184(CHEMBL3604466)
Affinity DataIC50:  514nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6221(8-Ethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-...)
Affinity DataIC50:  620nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113282(CHEMBL456163)
Affinity DataIC50:  850nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
LigandPNGBDBM50113349(CHEMBL457388)
Affinity DataIC50:  980nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110182(CHEMBL3604464)
Affinity DataIC50:  1.01E+3nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM24634(N-phenyl-1H-indazole-3-carboxamide | indazole amid...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin) expressed in baculovirus infected insect cells using GST-fused pRb (792 to 928) as substrate preincubated for 2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110187(CHEMBL3604469)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088360(2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,...)
Affinity DataIC50:  1.70E+4nMAssay Description:Competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110177(CHEMBL3604461)
Affinity DataIC50:  2.70E+4nMAssay Description:Non-competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110175(CHEMBL3604459)
Affinity DataIC50:  4.50E+4nMAssay Description:Competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110176(CHEMBL3604460)
Affinity DataIC50:  7.10E+4nMAssay Description:Non-competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM24627(1H-indazole | Indazole, 5 | Indazole, 6)
Affinity DataIC50:  1.85E+5nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair