Compile Data Set for Download or QSAR
maximum 50k data
Found 6 Enz. Inhib. hit(s) with all data for entry = 50046437
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of CXCR4 in human Jurkat cells assessed as reduction in HIV-Nef-M1-induced mitochondrial membrane depolarization at 0.01 to 100 uM by JC1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataIC50:  1.00E+4nMAssay Description:Antagonist activity against CXCR4 (unknown origin) by Ca2+ flux GPCR signaling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of CCR5 assessed as reduction in fusion of effector cells expressing JRFL envelope (CCR5-tropic/CD4-dependent) with human HeLa-C14 target ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50112267(CHEMBL3608771)
Affinity DataIC50:  7.00E+4nMAssay Description:Displacement of [125I]-MIP-1beta form CCR5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataEC50:  5.20E+4nMAssay Description:Inhibition of CXCR4 assessed as reduction in fusion of human ACTOne-X4 cells as target cells expressing only CXCR4) with effector cells expressing HI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataEC50:  7.00E+4nMAssay Description:Inhibition of CXCR4 assessed as reduction in fusion of human HeLa/67 as target cells expressing CD4, CCR5, and CXCR4) and Lai envelope-expressing eff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed