Compile Data Set for Download or QSAR
maximum 50k data
Found 248 Enz. Inhib. hit(s) with all data for entry = 50047300
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  40nMAssay Description:Inhibition of human recombinant KDM1A expressed in Escherichia coli using H3K4me as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM113742(N-[4-(2-Hydrazinylethyl)phenyl]-4-phenylbutanamide...)
Affinity DataKi:  59nMAssay Description:Inhibition of GST-tagged KDM1A (unknown origin) expressed in Escherichia coli BL21-CodonPlus-(DE3)-RIPL cells using dimethyl-Lys-4 H3-21 as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158884(CHEMBL3785550)
Affinity DataKi:  140nMAssay Description:Inhibition of human recombinant His-tagged KDM1A (171 to 836 residues) using H3K4me2 as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158882(CHEMBL3786209)
Affinity DataKi:  210nMAssay Description:Inhibition of human recombinant His-tagged KDM1A (171 to 836 residues) using H3K4me2 as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158883(CHEMBL3785964)
Affinity DataKi:  240nMAssay Description:Inhibition of human recombinant His-tagged KDM1A (171 to 836 residues) using H3K4me2 as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158852(CHEMBL3785340)
Affinity DataKi:  280nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM2A (1 to 517 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataKi:  420nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM2A (1 to 517 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158852(CHEMBL3785340)
Affinity DataKi:  420nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataKi:  520nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataKi:  1.50E+3nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM2A (1 to 517 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of KDM1A (unknown origin) by peroxidase coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158881(CHEMBL3785549)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human recombinant KDM1A expressed in Escherichia coli using H3K4me as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataKi:  1.94E+3nMAssay Description:Competitive inhibition of human KDM4A (1 to 359 residues) expressed in competent Escherichia coli BL21-CodonPlus-RIL cells using 2-oxoglutarate as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158886(CHEMBL3787012)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of human recombinant His-tagged KDM1A (171 to 836 residues) using H3K4me2 as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataKi:  3.02E+3nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158887(CHEMBL3786042)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of human recombinant His-tagged KDM1A (171 to 836 residues) using H3K4me2 as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158885(CHEMBL3787118)
Affinity DataKi:  2.84E+4nMAssay Description:Inhibition of human recombinant His-tagged KDM1A (171 to 836 residues) using H3K4me2 as substrate by peroxidase coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158832(CHEMBL3786038)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of recombinant full length FLAG-tagged KDM5A (unknown origin) expressed in sf9 cells using biotin-H3K4me3 (1 to 21 residues as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158870(CHEMBL3787230)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant GST-tagged KDM1A (172 to 833 residues) expressed in Escherichia coli C43(DE3) pLysS cells using biotin-H3K4me as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158871(CHEMBL3786192)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant GST-tagged KDM1A (172 to 833 residues) expressed in Escherichia coli C43(DE3) pLysS cells using biotin-H3K4me as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158872(CHEMBL3785523)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant GST-tagged KDM1A (172 to 833 residues) expressed in Escherichia coli C43(DE3) pLysS cells using biotin-H3K4me as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158880(CHEMBL3785783 | US10131664, Example 16 | US1054319...)
Affinity DataIC50: <10nMAssay Description:Inhibition of KDM1A in human THP1 cells assessed as inhibition of CD11b expressing cells incubated for 4 days by DAPI staining based flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158844(CHEMBL3785491)
Affinity DataIC50:  10nMAssay Description:Inhibition of human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using H3K4me3 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158880(CHEMBL3785783 | US10131664, Example 16 | US1054319...)
Affinity DataIC50: <10nMAssay Description:Inhibition of full length human KDM1A expressed in Escherichia coli using biotin-H3K4me1 as substrate incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158830(CHEMBL3785583)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant full length FLAG-tagged KDM5A (unknown origin) expressed in sf9 cells using biotin-H3K4me3 (1 to 21 residues as substrate p...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158831(CHEMBL3785443)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant full length FLAG-tagged KDM5A (unknown origin) expressed in sf9 cells using biotin-H3K4me3 (1 to 21 residues as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158875(CHEMBL3787372 | US9676701, 69 N-(4′-((trans)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged KDM1A expressed in Escherichia coli using H3K4me2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158694(CHEMBL3786803 | US10273222, Example 12)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158695(CHEMBL3787664 | US10273222, Example 16)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158696(CHEMBL3786225)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158703(CHEMBL3785832 | US10173996, Example 53 | US9604961...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158755(CHEMBL3786579 | US10173996, Example 109 | US960496...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158791(CHEMBL3786596 | US10179769, Example 42 | US1080795...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158794(CHEMBL3785470 | US10040779, Example 29 | US1033672...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158801(CHEMBL3786617)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158803(CHEMBL3787438 | US10040779, Example 75 | US1033672...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-FLAG-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged KDM2B (1 to 650 residues) expressed in baculovirus infected sf9 cells using biotin-H3K36me2 as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KDM4A (1 to 350 residues) expressed in Escherichia coli using methylated biotin-H3K9 substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50: <100nMAssay Description:Inhibition of human N-terminal GST-tagged KDM4B (1 to 500 residues) expressed in baculovirus infected sf9 cells using biotinylated histone H3 as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM4C (1 to 349 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158859(CHEMBL3787193)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM4C (1 to 349 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Affinity DataIC50:  100nMAssay Description:Inhibition of KDM4C (1 to 349 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for 10...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM5B (1 to 809 residues) (unknown origin) expressed in Escherichia coli using biotin-H3K4me3 as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158859(CHEMBL3787193)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM5B (1 to 809 residues) (unknown origin) expressed in Escherichia coli using biotin-H3K4me3 as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Affinity DataIC50:  100nMAssay Description:Inhibition of KDM5B (1 to 809 residues) (unknown origin) expressed in Escherichia coli using biotin-H3K4me3 as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged KDM5C (2 to 1560 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3 as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158859(CHEMBL3787193)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Affinity DataIC50: <100nMAssay Description:Inhibition of KDM6A (919 to 1401 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 as substrate preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50158863(CHEMBL3785706)
Affinity DataIC50: <100nMAssay Description:Inhibition of human recombinant KDM1A expressed in Escherichia coli using biotin-histone H3 as substrate preincubated for 1 hr followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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