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Found 23 Enz. Inhib. hit(s) with all data for entry = 50048017
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201022(CHEMBL3897632 | US10155727, Example 6 | USRE49517,...)
Affinity DataIC50:  5.20nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201028(CHEMBL3954438 | US10155727, Example 18 | USRE49517...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201023(CHEMBL3927856 | US10155727, Example 7 | USRE49517,...)
Affinity DataIC50:  8.20nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201024(CHEMBL3936854 | US10155727, Example 4 | USRE49517,...)
Affinity DataIC50:  119nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201022(CHEMBL3897632 | US10155727, Example 6 | USRE49517,...)
Affinity DataIC50:  230nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201023(CHEMBL3927856 | US10155727, Example 7 | USRE49517,...)
Affinity DataIC50:  350nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201028(CHEMBL3954438 | US10155727, Example 18 | USRE49517...)
Affinity DataIC50:  370nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50:  890nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201027(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Affinity DataIC50:  1.01E+3nMAssay Description:Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201024(CHEMBL3936854 | US10155727, Example 4 | USRE49517,...)
Affinity DataIC50:  1.75E+3nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50:  2.46E+3nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201027(CHEMBL3945735 | US10155727, Example 30 | USRE49517...)
Affinity DataIC50:  3.47E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  3.70E+3nMAssay Description:Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201025(CHEMBL3975087 | US10155727, Example 26 | USRE49517...)
Affinity DataIC50:  4.75E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201021(CHEMBL3966599 | US10155727, Example 2 | USRE49517,...)
Affinity DataIC50:  8.08E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201022(CHEMBL3897632 | US10155727, Example 6 | USRE49517,...)
Affinity DataIC50:  9.56E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201026(CHEMBL3983077 | US10155727, Example 17 | USRE49517...)
Affinity DataIC50:  3.50E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201024(CHEMBL3936854 | US10155727, Example 4 | USRE49517,...)
Affinity DataIC50:  5.24E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201023(CHEMBL3927856 | US10155727, Example 7 | USRE49517,...)
Affinity DataIC50:  5.26E+4nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50201028(CHEMBL3954438 | US10155727, Example 18 | USRE49517...)
Affinity DataIC50:  1.35E+5nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed