Compile Data Set for Download or QSAR
maximum 50k data
Found 10 Enz. Inhib. hit(s) with all data for entry = 50048986
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232462(ADX-10059 | Raseglurant)
Affinity DataIC50:  17nMAssay Description:Negative allosteric modulation of mGlu5 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  36nMAssay Description:Negative allosteric modulation of recombinant human mGlu5a receptor assessed as inhibition of quisqualate-stimulated phosphoinositide hydrolysis by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50:  58nMAssay Description:Negative allosteric modulation of human mGlu5a receptor expressed in HEK293 cells co-expressing EAAC1 assessed as inhibition of quisqualate-induced i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232458(CHEMBL4064885)
Affinity DataIC50:  430nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232463(CHEMBL4073483)
Affinity DataIC50:  960nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232459(CHEMBL4094126)
Affinity DataIC50:  1.21E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50179663(1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...)
Affinity DataIC50:  2.30E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232460(CHEMBL4101860)
Affinity DataIC50:  3.09E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232461(CHEMBL4083861)
Affinity DataIC50:  4.92E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Advanced Chemistry Of Catalonia (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50232472(CHEMBL4063852)
Affinity DataIC50:  6.13E+3nMAssay Description:Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed